메뉴 건너뛰기




Volumn 59, Issue 9, 2013, Pages 3158-3166

Hypoxia and flow perfusion modulate proliferation and gene expression of articular chondrocytes on porous scaffolds

Author keywords

Articular chondrocytes; Cartilage tissue engineering; Electrospun scaffold; Flow perfusion bioreactor; Hypoxia

Indexed keywords

ARTICULAR CHONDROCYTES; CARTILAGE TISSUE ENGINEERING; ELECTROSPUN SCAFFOLDS; FLOW PERFUSION BIOREACTOR; HYPOXIA;

EID: 84881670418     PISSN: 00011541     EISSN: 15475905     Source Type: Journal    
DOI: 10.1002/aic.13958     Document Type: Article
Times cited : (17)

References (62)
  • 1
    • 0036083985 scopus 로고    scopus 로고
    • Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects
    • Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartilage. 2002;10(6):432-463.
    • (2002) Osteoarthr Cartilage. , vol.10 , Issue.6 , pp. 432-463
    • Hunziker, E.B.1
  • 2
    • 34147150632 scopus 로고    scopus 로고
    • Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030
    • Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg AM. 2007;89A(4):780-785.
    • (2007) J Bone Joint Surg AM. , vol.89 A , Issue.4 , pp. 780-785
    • Kurtz, S.1    Ong, K.2    Lau, E.3    Mowat, F.4    Halpern, M.5
  • 4
    • 0030972757 scopus 로고    scopus 로고
    • Current concepts in the treatment of articular cartilage defects
    • Minas T, Nehrer S. Current concepts in the treatment of articular cartilage defects. Orthopedics. 1997;20(6):525-538.
    • (1997) Orthopedics. , vol.20 , Issue.6 , pp. 525-538
    • Minas, T.1    Nehrer, S.2
  • 5
    • 80052965339 scopus 로고    scopus 로고
    • Recent progress in cartilage tissue engineering
    • Keeney M, Lai JH, Yang F. Recent progress in cartilage tissue engineering. Curr Opin Biotech. 2011;22(5):734-740.
    • (2011) Curr Opin Biotech. , vol.22 , Issue.5 , pp. 734-740
    • Keeney, M.1    Lai, J.H.2    Yang, F.3
  • 6
    • 39749185584 scopus 로고    scopus 로고
    • The use of mesenchymal stem cells for chondrogenesis
    • Pelttari K, Steck E, Richter W. The use of mesenchymal stem cells for chondrogenesis. Injury. 2008;39:S58-S65.
    • (2008) Injury. , vol.39
    • Pelttari, K.1    Steck, E.2    Richter, W.3
  • 7
    • 65549090503 scopus 로고    scopus 로고
    • The osteochondral junction and its repair via bi-phasic tissue engineering scaffolds
    • Keeney M, Pandit A. The osteochondral junction and its repair via bi-phasic tissue engineering scaffolds. Tissue Eng Part B. 2009;15(1):55-73.
    • (2009) Tissue Eng Part B. , vol.15 , Issue.1 , pp. 55-73
    • Keeney, M.1    Pandit, A.2
  • 8
    • 0020369710 scopus 로고
    • Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
    • Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell. 1982;30(1):215-224.
    • (1982) Cell. , vol.30 , Issue.1 , pp. 215-224
    • Benya, P.D.1    Shaffer, J.D.2
  • 9
    • 57549094818 scopus 로고    scopus 로고
    • A comparison of primary and passaged chondrocytes for use in engineering the temporomandibular joint
    • Anderson DEJ, Athanasiou KA. A comparison of primary and passaged chondrocytes for use in engineering the temporomandibular joint. Arch Oral Biol. 2009;54(2):138-145.
    • (2009) Arch Oral Biol. , vol.54 , Issue.2 , pp. 138-145
    • Anderson, D.E.J.1    Athanasiou, K.A.2
  • 10
    • 0037082703 scopus 로고    scopus 로고
    • Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels
    • Hunter CJ, Imler SM, Malaviya P, Nerem RM, Levenston ME. Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels. Biomater. 2002;23(4):1249-1259.
    • (2002) Biomater. , vol.23 , Issue.4 , pp. 1249-1259
    • Hunter, C.J.1    Imler, S.M.2    Malaviya, P.3    Nerem, R.M.4    Levenston, M.E.5
  • 11
    • 0037326275 scopus 로고    scopus 로고
    • Articular cartilage bioreactors and bioprocesses
    • Darling E, Athanasiou K. Articular cartilage bioreactors and bioprocesses. Tissue Eng. 2003;9(1):9-26.
    • (2003) Tissue Eng. , vol.9 , Issue.1 , pp. 9-26
    • Darling, E.1    Athanasiou, K.2
  • 12
    • 72149105318 scopus 로고    scopus 로고
    • Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels
    • Nicodemus GD, Bryant SJ. Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels. Osteoarthr Cartilage. 2010;18(1):126-137.
    • (2010) Osteoarthr Cartilage. , vol.18 , Issue.1 , pp. 126-137
    • Nicodemus, G.D.1    Bryant, S.J.2
  • 13
    • 0036791972 scopus 로고    scopus 로고
    • Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner
    • Bancroft GN, Sikavitsas VI, van denDolder J et al. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. P Natl Acad Sci USA. 2002;99(20):12600-12605.
    • (2002) P Natl Acad Sci USA. , vol.99 , Issue.20 , pp. 12600-12605
    • Bancroft, G.N.1    Sikavitsas, V.I.2    Van Den Dolder, J.3
  • 14
    • 1642563967 scopus 로고    scopus 로고
    • The role of bioreactors in tissue engineering
    • Martin I, Wendt D, Heberer M. The role of bioreactors in tissue engineering. Trends Biotechnol. 2004;22(2):80-86.
    • (2004) Trends Biotechnol. , vol.22 , Issue.2 , pp. 80-86
    • Martin, I.1    Wendt, D.2    Heberer, M.3
  • 15
    • 0037937606 scopus 로고    scopus 로고
    • Design of a flow perfusion bioreactor system for bone tissue-engineering applications
    • Bancroft G, Sikavitsas V, Mikos A. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng. 2003;9(3):549-554.
    • (2003) Tissue Eng. , vol.9 , Issue.3 , pp. 549-554
    • Bancroft, G.1    Sikavitsas, V.2    Mikos, A.3
  • 16
    • 0036773416 scopus 로고    scopus 로고
    • Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures
    • Davisson T, Sah RL, Ratcliffe A. Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures. Tissue Eng. 2002;8(5):807-816.
    • (2002) Tissue Eng. , vol.8 , Issue.5 , pp. 807-816
    • Davisson, T.1    Sah, R.L.2    Ratcliffe, A.3
  • 17
    • 33646364803 scopus 로고    scopus 로고
    • Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage
    • Gemmiti CV, Guldberg RE. Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage. Tissue Eng. 2006;12(3):469-479.
    • (2006) Tissue Eng. , vol.12 , Issue.3 , pp. 469-479
    • Gemmiti, C.V.1    Guldberg, R.E.2
  • 18
    • 0034281606 scopus 로고    scopus 로고
    • Comparison of chondrogensis in static and perfused bioreactor culture
    • Pazzano D, Mercier KA, Moran JM et al. Comparison of chondrogensis in static and perfused bioreactor culture. Biotechnol Progr. 2000;16(5):893-896.
    • (2000) Biotechnol Progr. , vol.16 , Issue.5 , pp. 893-896
    • Pazzano, D.1    Mercier, K.A.2    Moran, J.M.3
  • 19
    • 0033826315 scopus 로고    scopus 로고
    • Bovine articular chondrocyte function in vitro depends upon oxygen tension
    • Grimshaw MJ, Mason RM. Bovine articular chondrocyte function in vitro depends upon oxygen tension. Osteoarthr Cartilage. 2000;8(5):386-392.
    • (2000) Osteoarthr Cartilage. , vol.8 , Issue.5 , pp. 386-392
    • Grimshaw, M.J.1    Mason, R.M.2
  • 20
    • 22644441306 scopus 로고    scopus 로고
    • Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes?
    • Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthr and Cartilage. 2005;13(8):643-654.
    • (2005) Osteoarthr and Cartilage. , vol.13 , Issue.8 , pp. 643-654
  • 21
    • 24344480012 scopus 로고    scopus 로고
    • Hypoxia and HIF-1α in chondrogenesis
    • Schipani E. Hypoxia and HIF-1α in chondrogenesis. Semin Cell Dev Biol. 2005;16(4-5):539-546.
    • (2005) Semin Cell Dev Biol. , vol.16 , Issue.4-5 , pp. 539-546
    • Schipani, E.1
  • 22
    • 77956882362 scopus 로고    scopus 로고
    • Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes
    • Buckley CT, Vinardell T, Kelly DJ. Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes. Osteoarthr Cartilage. 2010;18(10):1345-1354.
    • (2010) Osteoarthr Cartilage. , vol.18 , Issue.10 , pp. 1345-1354
    • Buckley, C.T.1    Vinardell, T.2    Kelly, D.J.3
  • 23
    • 0035674325 scopus 로고    scopus 로고
    • Effect of oxygen tension and alginate encapsulation on restoration of the differentiated phenotype of passaged chondrocytes
    • Murphy CL, Sambanis A. Effect of oxygen tension and alginate encapsulation on restoration of the differentiated phenotype of passaged chondrocytes. Tissue Eng. 2001;7(6):791-803.
    • (2001) Tissue Eng. , vol.7 , Issue.6 , pp. 791-803
    • Murphy, C.L.1    Sambanis, A.2
  • 24
    • 2342457824 scopus 로고    scopus 로고
    • Control of human articular chondrocyte differentiation by reduced oxygen tension
    • Murphy CL, Polak JM. Control of human articular chondrocyte differentiation by reduced oxygen tension. J Cell Physiol. 2004;199(3):451-459.
    • (2004) J Cell Physiol. , vol.199 , Issue.3 , pp. 451-459
    • Murphy, C.L.1    Polak, J.M.2
  • 25
    • 66249144073 scopus 로고    scopus 로고
    • Sustained hypoxia enhances chondrocyte matrix synthesis
    • Coyle CH, Izzo NJ, Chu CR. Sustained hypoxia enhances chondrocyte matrix synthesis. J Orthopaed Res. 2009;27(6):793-799.
    • (2009) J Orthopaed Res. , vol.27 , Issue.6 , pp. 793-799
    • Coyle, C.H.1    Izzo, N.J.2    Chu, C.R.3
  • 26
    • 84867003190 scopus 로고    scopus 로고
    • Design of a high-throughput flow perfusion bioreactor system for tissue engineering
    • Dahlin RL, Meretoja VV, Ni M, Kasper FK, Mikos AG. Design of a high-throughput flow perfusion bioreactor system for tissue engineering. Tissue Eng Part C. 2012;18(10):817-820.
    • (2012) Tissue Eng Part C , vol.18 , Issue.10 , pp. 817-820
    • Dahlin, R.L.1    Meretoja, V.V.2    Ni, M.3    Kasper, F.K.4    Mikos, A.G.5
  • 27
    • 77957321280 scopus 로고    scopus 로고
    • Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering
    • Liao J, Guo X, Grande-Allen K, Kasper F, Mikos A. Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering. Biomater. 2010;31(34):8911-8920.
    • (2010) Biomater. , vol.31 , Issue.34 , pp. 8911-8920
    • Liao, J.1    Guo, X.2    Grande-Allen, K.3    Kasper, F.4    Mikos, A.5
  • 28
    • 84863588215 scopus 로고    scopus 로고
    • Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells
    • Meretoja VV, Dahlin RL, Kasper FK, Mikos AG. Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells. Biomater. 2012;33(27):6362-6369.
    • (2012) Biomater. , vol.33 , Issue.27 , pp. 6362-6369
    • Meretoja, V.V.1    Dahlin, R.L.2    Kasper, F.K.3    Mikos, A.G.4
  • 29
    • 33750315715 scopus 로고    scopus 로고
    • Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration
    • Pham QP, Sharma U, Mikos AG. Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration. Biomacromol. 2006;7(10):2796-2805.
    • (2006) Biomacromol. , vol.7 , Issue.10 , pp. 2796-2805
    • Pham, Q.P.1    Sharma, U.2    Mikos, A.G.3
  • 30
    • 79960371944 scopus 로고    scopus 로고
    • Chondrogenic differentiation of neonatal human dermal fibroblasts encapsulated in alginate beads with hydrostatic compression under hypoxic conditions in the presence of bone morphogenetic protein-2
    • Singh M, Pierpoint M, Mikos AG, Kasper FK. Chondrogenic differentiation of neonatal human dermal fibroblasts encapsulated in alginate beads with hydrostatic compression under hypoxic conditions in the presence of bone morphogenetic protein-2. J Biomed Mater Res A. 2011;98(3):412-424.
    • (2011) J Biomed Mater Res A. , vol.98 , Issue.3 , pp. 412-424
    • Singh, M.1    Pierpoint, M.2    Mikos, A.G.3    Kasper, F.K.4
  • 31
    • 77955885763 scopus 로고    scopus 로고
    • Modulation of osteogenic properties of biodegradable polymer/extracellular matrix scaffolds generated with a flow perfusion bioreactor
    • Liao J, Guo X, Nelson D, Kasper FK, Mikos AG. Modulation of osteogenic properties of biodegradable polymer/extracellular matrix scaffolds generated with a flow perfusion bioreactor. Acta Biomater. 2010;6(7):2386-2393.
    • (2010) Acta Biomater. , vol.6 , Issue.7 , pp. 2386-2393
    • Liao, J.1    Guo, X.2    Nelson, D.3    Kasper, F.K.4    Mikos, A.G.5
  • 32
    • 33644517215 scopus 로고    scopus 로고
    • In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation
    • Datta N, Pham QP, Sharma U, Sikavitsas VI, Jansen JA, Mikos AG. In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. P Natl Acad Sci USA. 2006;103(8):2488-2493.
    • (2006) P Natl Acad Sci USA. , vol.103 , Issue.8 , pp. 2488-2493
    • Datta, N.1    Pham, Q.P.2    Sharma, U.3    Sikavitsas, V.I.4    Jansen, J.A.5    Mikos, A.G.6
  • 34
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(t) method
    • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(t) method. Nat Protoc. 2008;3(6): 1101-1108.
    • (2008) Nat Protoc. , vol.3 , Issue.6 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 35
    • 0036773416 scopus 로고    scopus 로고
    • Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures
    • Davisson T, Sah RL, Ratcliffe A. Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures. Tissue Eng. 2002;8(5):807-816.
    • (2002) Tissue Eng. , vol.8 , Issue.5 , pp. 807-816
    • Davisson, T.1    Sah, R.L.2    Ratcliffe, A.3
  • 36
    • 0033043139 scopus 로고    scopus 로고
    • Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage
    • Vunjak-Novakovic G, Martin I, Obradovic B et al. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage. J Orthopaed Res. 1999;17(1):130-138.
    • (1999) J Orthopaed Res. , vol.17 , Issue.1 , pp. 130-138
    • Vunjak-Novakovic, G.1    Martin, I.2    Obradovic, B.3
  • 37
    • 0034281606 scopus 로고    scopus 로고
    • Comparison of chondrogensis in static and perfused bioreactor culture
    • Pazzano D, Mercier KA, Moran JM et al. Comparison of chondrogensis in static and perfused bioreactor culture. Biotechnol Progr. 2000;16(5):893-896.
    • (2000) Biotechnol Progr. , vol.16 , Issue.5 , pp. 893-896
    • Pazzano, D.1    Mercier, K.A.2    Moran, J.M.3
  • 38
    • 33646364803 scopus 로고    scopus 로고
    • Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage
    • Gemmiti CV, Guldberg RE. Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage. Tissue Eng. 2006;12(3):469-479.
    • (2006) Tissue Eng. , vol.12 , Issue.3 , pp. 469-479
    • Gemmiti, C.V.1    Guldberg, R.E.2
  • 39
    • 4544342994 scopus 로고    scopus 로고
    • Effect of oxygen tension on adult articular chondrocytes in microcarrier bioreactor culture
    • 7��8
    • Malda J, Van denBrink P, Meeuwse P et al. Effect of oxygen tension on adult articular chondrocytes in microcarrier bioreactor culture. Tissue Eng. 2004;10(7��8):987-994.
    • (2004) Tissue Eng. , vol.10 , pp. 987-994
    • Malda, J.1    Van Den Brink, P.2    Meeuwse, P.3
  • 40
    • 73949125596 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle
    • Aitken KJ, Tolg C, Panchal T et al. Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle. Am J Pathol. 2010;176(1):304-319.
    • (2010) Am J Pathol. , vol.176 , Issue.1 , pp. 304-319
    • Aitken, K.J.1    Tolg, C.2    Panchal, T.3
  • 41
    • 80051693084 scopus 로고    scopus 로고
    • Strategies for enhancing the accumulation and retention of extracellular matrix in tissue-engineered cartilage cultured in bioreactors
    • Shahin K, Doran PM. Strategies for enhancing the accumulation and retention of extracellular matrix in tissue-engineered cartilage cultured in bioreactors. PloS One. 2011;6(8):e23119.
    • (2011) PloS One. , vol.6 , Issue.8
    • Shahin, K.1    Doran, P.M.2
  • 43
    • 0031706086 scopus 로고    scopus 로고
    • Composition and dynamics of articular cartilage: structure, function, and maintaining healthy state
    • Cohen NP, Foster RJ, Mow VC. Composition and dynamics of articular cartilage: structure, function, and maintaining healthy state. J Orthop Sports Phys. 1998;28(4):203-215.
    • (1998) J Orthop Sports Phys. , vol.28 , Issue.4 , pp. 203-215
    • Cohen, N.P.1    Foster, R.J.2    Mow, V.C.3
  • 44
    • 0031830443 scopus 로고    scopus 로고
    • Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression
    • Valhmu WB, Stazzone EJ, Bachrach NM et al. Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression. Arch Biochem Biophys. 1998;353(1):29-36.
    • (1998) Arch Biochem Biophys. , vol.353 , Issue.1 , pp. 29-36
    • Valhmu, W.B.1    Stazzone, E.J.2    Bachrach, N.M.3
  • 45
    • 33644517215 scopus 로고    scopus 로고
    • In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation
    • Datta N, Pham QP, Sharma U, Sikavitsas VI, Jansen JA, Mikos AG. In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. P Natl Acad Sci USA. 2006;103(8):2488-2493.
    • (2006) P Natl Acad Sci USA. , vol.103 , Issue.8 , pp. 2488-2493
    • Datta, N.1    Pham, Q.P.2    Sharma, U.3    Sikavitsas, V.I.4    Jansen, J.A.5    Mikos, A.G.6
  • 46
    • 59649088326 scopus 로고    scopus 로고
    • Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage
    • Blaise R, Mahjoub M, Salvat C et al. Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage. Arthritis Rheum. 2009;60(2):428-439.
    • (2009) Arthritis Rheum. , vol.60 , Issue.2 , pp. 428-439
    • Blaise, R.1    Mahjoub, M.2    Salvat, C.3
  • 47
    • 0035812493 scopus 로고    scopus 로고
    • Effects of medium perfusion on matrix production by bovine chondrocytes in three-dimensional collagen sponges
    • Mizuno S, Allemann F, Glowacki J. Effects of medium perfusion on matrix production by bovine chondrocytes in three-dimensional collagen sponges. J Biomed Mater Res. 2001;56(3):368-375.
    • (2001) J Biomed Mater Res. , vol.56 , Issue.3 , pp. 368-375
    • Mizuno, S.1    Allemann, F.2    Glowacki, J.3
  • 48
    • 0035372005 scopus 로고    scopus 로고
    • Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds
    • Goldstein AS, Juarez TM, Helmke CD, Gustin MC, Mikos AG. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomater. 2001;22(11):1279-1288.
    • (2001) Biomater. , vol.22 , Issue.11 , pp. 1279-1288
    • Goldstein, A.S.1    Juarez, T.M.2    Helmke, C.D.3    Gustin, M.C.4    Mikos, A.G.5
  • 49
    • 0348015827 scopus 로고    scopus 로고
    • Influence of the in vitro culture period on the in vivo performance of cell/titanium bone tissue-engineered constructs using a rat cranial critical size defect model
    • Sikavitsas VI, van denDolder J, Bancroft GN, Jansen JA, Mikos AG. Influence of the in vitro culture period on the in vivo performance of cell/titanium bone tissue-engineered constructs using a rat cranial critical size defect model. J Biomed Mater Res A. 2003;67A(3):944-951.
    • (2003) J Biomed Mater Res A. , vol.67 A , Issue.3 , pp. 944-951
    • Sikavitsas, V.I.1    van den Dolder, J.2    Bancroft, G.N.3    Jansen, J.A.4    Mikos, A.G.5
  • 50
    • 33747146367 scopus 로고    scopus 로고
    • The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion
    • Raimondi MT, Moretti M, Cioffi M et al. The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion. Biorheology. 2006;43(3-4):215-222.
    • (2006) Biorheology. , vol.43 , Issue.3-4 , pp. 215-222
    • Raimondi, M.T.1    Moretti, M.2    Cioffi, M.3
  • 51
    • 4644288264 scopus 로고    scopus 로고
    • The effect of media perfusion on three-dimensional cultures of human chondrocytes: integration of experimental and computational approaches
    • 3��4
    • Raimondi MT, Boschetti F, Falcone L, Migliavacca F, Remuzzi A, Dubini G. The effect of media perfusion on three-dimensional cultures of human chondrocytes: integration of experimental and computational approaches. Biorheology. 2004;41(3��4):401-410.
    • (2004) Biorheology. , vol.41 , pp. 401-410
    • Raimondi, M.T.1    Boschetti, F.2    Falcone, L.3    Migliavacca, F.4    Remuzzi, A.5    Dubini, G.6
  • 52
    • 52449134952 scopus 로고    scopus 로고
    • Engineered cartilage constructs subject to very low regimens of interstitial perfusion
    • Raimondi MT, Candiani G, Cabras M et al. Engineered cartilage constructs subject to very low regimens of interstitial perfusion. Biorheology. 2008;45(3-4):471-478.
    • (2008) Biorheology. , vol.45 , Issue.3-4 , pp. 471-478
    • Raimondi, M.T.1    Candiani, G.2    Cabras, M.3
  • 53
    • 73349101432 scopus 로고    scopus 로고
    • Population doublings and percentage of S100-positive cells as predictors of in vitro chondrogenicity of expanded human articular chondrocytes
    • Giovannini S, Diaz-Romero J, Aigner T, Mainil-Varlet P, Nesic D. Population doublings and percentage of S100-positive cells as predictors of in vitro chondrogenicity of expanded human articular chondrocytes. J Cell Physiol. 2010;222(2):411-420.
    • (2010) J Cell Physiol. , vol.222 , Issue.2 , pp. 411-420
    • Giovannini, S.1    Diaz-Romero, J.2    Aigner, T.3    Mainil-Varlet, P.4    Nesic, D.5
  • 54
    • 0037530143 scopus 로고    scopus 로고
    • Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo
    • Dell'Accio F, DeBari C, Luyten FP. Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo. Exp Cell Res. 2003;287(1):16-27.
    • (2003) Exp Cell Res. , vol.287 , Issue.1 , pp. 16-27
    • Dell'Accio, F.1    De Bari, C.2    Luyten, F.P.3
  • 55
    • 0033983594 scopus 로고    scopus 로고
    • Review: tissue engineering for regeneration of articular cartilage
    • Temenoff JS, Mikos AG. Review: tissue engineering for regeneration of articular cartilage. Biomater. 2000;21(5):431-440.
    • (2000) Biomater. , vol.21 , Issue.5 , pp. 431-440
    • Temenoff, J.S.1    Mikos, A.G.2
  • 56
    • 0033572770 scopus 로고    scopus 로고
    • Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue
    • Martin I, Vunjak-Novakovic G, Yang J, Langer R, Freed LE. Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue. Exp Cell Res. 1999;253(2):681-688.
    • (1999) Exp Cell Res. , vol.253 , Issue.2 , pp. 681-688
    • Martin, I.1    Vunjak-Novakovic, G.2    Yang, J.3    Langer, R.4    Freed, L.E.5
  • 57
    • 33746714341 scopus 로고    scopus 로고
    • Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size
    • Li WJ, Jiang YJ, Tuan RS. Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng. 2006;12(7):1775-1785.
    • (2006) Tissue Eng. , vol.12 , Issue.7 , pp. 1775-1785
    • Li, W.J.1    Jiang, Y.J.2    Tuan, R.S.3
  • 58
    • 0034982488 scopus 로고    scopus 로고
    • Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering
    • Hansen U, Schunke M, Domm C et al. Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering. J Biomech. 2001;34(7):941-949.
    • (2001) J Biomech. , vol.34 , Issue.7 , pp. 941-949
    • Hansen, U.1    Schunke, M.2    Domm, C.3
  • 59
    • 0034053504 scopus 로고    scopus 로고
    • Redifferentiation of dedifferentiated joint cartilage cells in alginate culture. Effect of intermittent hydrostatic pressure and low oxygen partial pressure
    • Domm C, Fay J, Schunke M, Kurz B. Redifferentiation of dedifferentiated joint cartilage cells in alginate culture. Effect of intermittent hydrostatic pressure and low oxygen partial pressure. Der Orthopade. 2000;29(2):91-99.
    • (2000) Der Orthopade. , vol.29 , Issue.2 , pp. 91-99
    • Domm, C.1    Fay, J.2    Schunke, M.3    Kurz, B.4
  • 60
    • 79960371944 scopus 로고    scopus 로고
    • Chondrogenic differentiation of neonatal human dermal fibroblasts encapsulated in alginate beads with hydrostatic compression under hypoxic conditions in the presence of bone morphogenetic protein-2
    • Singh M, Pierpoint M, Mikos AG, Kasper FK. Chondrogenic differentiation of neonatal human dermal fibroblasts encapsulated in alginate beads with hydrostatic compression under hypoxic conditions in the presence of bone morphogenetic protein-2. J Biomed Mater Res A. 2011;98A(3):412-424.
    • (2011) J Biomed Mater Res A. , vol.98 A , Issue.3 , pp. 412-424
    • Singh, M.1    Pierpoint, M.2    Mikos, A.G.3    Kasper, F.K.4
  • 61
    • 79953823401 scopus 로고    scopus 로고
    • Combined 3D and hypoxic culture improves cartilage-specific gene expression in human chondrocytes
    • Foldager CB, Nielsen AB, Munir S et al. Combined 3D and hypoxic culture improves cartilage-specific gene expression in human chondrocytes. Acta Orthop. 2011;82(2):234-240.
    • (2011) Acta Orthop. , vol.82 , Issue.2 , pp. 234-240
    • Foldager, C.B.1    Nielsen, A.B.2    Munir, S.3
  • 62
    • 23844493183 scopus 로고    scopus 로고
    • Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9
    • Robins JC, Akeno N, Mukherjee A et al. Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone. 2005;37(3):313-322.
    • (2005) Bone. , vol.37 , Issue.3 , pp. 313-322
    • Robins, J.C.1    Akeno, N.2    Mukherjee, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.