Engineered cartilage constructs subject to very low regimens of interstitial perfusion

Biorheology

Volumn 45, Issue 3-4, 2008, Pages 471-478

  Raimondi, Manuela T ^a,b   Candiani, Gabriele ^a,c   Cabras, Mariasara ^a,c   Cioffi, Margherita ^a   Laganà, Katia ^a   Moretti, Matteo ^b   Pietrabissa, Riccardo ^a  

^a POLITECNICO DI MILANO   (Italy)

^b IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

^c CNR   (Italy)

Author keywords

Cartilage; Mechanobiology; Oxygen; Perfusion; Porous scaffold; Shear; Tissue engineering

Indexed keywords

ALPHA ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN;

ANIMAL CELL; CELL METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HYALINE CARTILAGE; HYDRODYNAMICS; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; SHEAR FLOW; SHEAR STRESS; TISSUE ENGINEERING; TISSUE PERFUSION; WESTERN BLOTTING;

ACTINS; ANIMALS; CARTILAGE; CARTILAGE, ARTICULAR; CATTLE; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHONDROCYTES; COLLAGEN; EXTRACELLULAR MATRIX; GLYCOSAMINOGLYCANS; MECHANOTRANSDUCTION, CELLULAR; OXYGEN; PERFUSION; SHEAR STRENGTH; TISSUE ENGINEERING;

EID: 52449134952     PISSN: 0006355X     EISSN: None     Source Type: Journal    
DOI: 10.3233/BIR-2008-0490     Document Type: Conference Paper

References (25)

1. B. Bilgen and G.A. Barabino, Location of scaffolds in bioreactors modulates the hydrodynamic environment experienced by engineered-tissues, Biotechnol. Bioeng. 98(1) (2007), 282-294.
2. F. Boschetti, M.T. Raimondi, F. Migliavacca and G. Dubini, Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors, J. Biomech. 39(3) (2006), 418-425.
3. E.M. Bueno, B. Bilgen and G.A. Barabino, Wavy-walled bioreactor supports increased cell proliferation and matrix deposition in engineered cartilage constructs, Tissue Eng. 11(11/12) (2005), 1699-1709.
4. M. Cioffi, F. Boschetti, M.T. Raimondi and G. Dubini, Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model, Biotechnol. Bioeng. 93(3) (2006), 500-510.
5. J.T. Connelly, E.J. Vanderploeg and M.E. Levenston, The influence of cyclic tension amplitude on chondrocyte matrix synthesis: Experimental and finite element analyses, Biorheology 41 (2004), 377-387.
6. T. Davisson, R.L. Sah and A. Ratcliffe, Perfusion increases cell content and matrix synthesis in chondrocyte threedimensional cultures, Tissue Eng. 8(5) (2002), 807-816.
7. O. Démarteau, D. Wendt, A. Braccini, M. Jakob, D. Schafer, M. Heberer and I. Martin, Dynamic compression of cartilage constructs engineered from expanded human articular chondrocytes, Biochem. Biophys. Res. Commun. 310(2) (2003), 580-588.
8. N.S. Dunkelman, M.P. Zimber, R.G. LeBaron, R. Pavelec, M. Kwan and A.F. Purchio, Cartilage production by rabbit articular chondrocytes on polyglycolic acid scaffolds in a closed bioreactor system, Biotechnol. Bioeng. 46 (1995), 299-305.
9. L.E. Freed and G. Vunjak-Novakovic, Tissue engineering bioreactors, in: Principles of Tissue Engineering, 2nd edn, R.P. Lanza, R. Langer and J. Vacanti, eds, Elsevier, 2000, pp. 143-156.
10. A.M. Freyria, Y. Yang, H. Chajra, C.F. Rousseau, M.C. Ronziere, D. Herbage and A.J. El Haj, Optimization of dynamic culture conditions: effects on biosynthetic activities of chondrocytes grown in collagen sponges, Tissue Eng. 11(5/6) (2005), 674-684.
11. C.V. Gemmiti and R.E. Guldberg, Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage, Tissue Eng. 12(3) (2006), 469-479.
12. M.J. Grimshaw and R.M. Mason, Articular chondrocyte function depends upon oxygen tension, Osteoarthr. Cartilage 8 (2000), 386-392.
13. J.C.Y. Hu and A. Athanasiou, The role of mechanical forces in tissue engineering of articular cartilage, in: Functional Tissue Engineering, F. Guilak, D.L. Butler, S.A. Goldstein and D.J. Mooney, eds, Springer-Verlag, New York, 2003, pp. 227-242.
14. C.J. Hunter and M.E. Levenston, The influence of repair tissue maturation on the response to oscillatory compression in a cartilage defect repair model, Biorheology 39 (2002), 79-88.
15. A.C. Kim and M. Spector, Distribution of chondrocytes containing alpha-smooth muscle actin in human articular cartilage, J. Orthop. Res. 18(5) (2000), 749-755.
16. J. Malda, P. van den Brink, P. Meeuwse, M. Grojec, D.E. Martens, J. Tramper et al., Effect of oxygen tension on adult articular chondrocytes in microcarrier bioreactor culture, Tissue Eng. 10 (2004), 987-994.
17. S.M. Mueller, T.O. Schneider, S. Shortkroff, H.A. Breinan and M. Spector, Alpha-smooth muscle actin and contractile behaviour of bovine meniscus cells seeded in type I and type II collagen-GAG matrices, J. Biomed. Mater. Res. 45(3) (1999), 157-166.
18. B. Obradovic, J.H. Meldon, L.E. Freed and G. Vunjak-Novakovic, Glycosaminoglycan deposition in engineered cartilage: Experiments and mathematical model, AIChE J. 46 (2000), 1860-1871.
19. D. Pazzano, K.A. Mercier, J.M. Moran, S.S. Fong, D.D. DiBiasio, J.X. Rulfs, S.S. Kohles and L.J. Bonassar, Comparison of chondrogensis in static and perfused bioreactor culture, Biotechnol. Prog. 16(5) (2000), 893-896.
20. M.T. Raimondi, F. Boschetti, L. Falcone, G.B. Fiore, A. Remuzzi, M. Marazzi, E. Marinoni and R. Pietrabissa, Mechanobiology of engineered cartilage cultured under a quantified fluid dynamic environment, Biomech. Model. Mechanobiol. 1 (2002), 69-82.
21. M.T. Raimondi, F. Boschetti, L. Falcone, F. Migliavacca, A. Remuzzi and G. Dubini, The effect of media perfusion on three-dimensional cultures of human chondrocytes: Integration of experimental and computational approaches, Biorheology 41(3/4) (2004), 401-410.
22. M.T. Raimondi, Engineered tissue as a model to study cell and tissue function from a biophysical perspective, Curr. Drug Disc. Technol. 3(4) (2006), 245-268.
23. M.T. Raimondi, M. Moretti, M. Cioffi, C. Giordano, F. Boschetti, K. Laganà and R. Pietrabissa, The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion, Biorheology 43(3/4) (2006), 215-222.
24. B. Saad, Y. Kuboki, M. Welti, G.K. Uhlschmid, P. Neuenschwander and U.W. Suter, DegraPol-foam: a degradable and highly porous polyesterurethane foam as a new substrate for bone formation, Artif. Organs 24(12) (2000), 939-945.
25. K.A. Williams, S. Saini and T.M. Wick, Computational fluid dynamics modeling of steady-state momentum and mass transport in a bioreactor for cartilage tissue engineering, Biotechnol. Prog. 18(5) (2002), 951-963.