Design of a high-throughput flow perfusion bioreactor system for tissue engineering

Tissue Engineering - Part C: Methods

Volumn 18, Issue 10, 2012, Pages 817-820

  Dahlin, Rebecca L ^a   Meretoja, Ville V ^a   Ni, Mengwei ^a   Kasper, F Kurtis ^a   Mikos, Antonios G ^a  

^a Rice University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTORS; THROUGHPUT;

FLOW CHAMBERS; FLOW PERFUSION; FLOW PERFUSION BIOREACTOR; HIGH-THROUGHPUT; PERFUSION BIOREACTOR;

TISSUE ENGINEERING;

ANIMAL; ARTICLE; BIOREACTOR; CARTILAGE CELL; CATTLE; CYTOLOGY; EQUIPMENT; EQUIPMENT DESIGN; FLOW KINETICS; HIGH THROUGHPUT SCREENING; METHODOLOGY; PERFUSION; TISSUE ENGINEERING;

ANIMALS; BIOREACTORS; CATTLE; CHONDROCYTES; EQUIPMENT DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; PERFUSION; RHEOLOGY; TISSUE ENGINEERING;

EID: 84867003190     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2012.0037     Document Type: Article

References (13)

1. Levorson, E.J., Kasper, F.K., and Mikos, A.G. Scaffolds: flow perfusion bioreactor design. In: Ducheyne, P., Healy, K.E., Hutmacher, D.W., Grainger, D.W., and Kirkpatrick, C.J., eds. Comprehensive Biomaterials. New York: Elsevier Ltd., 2011, pp. 1-11.
2. Pazzano, D., Mercier, K.A., Moran, J.M., Fong, S.S., DiBiasio, D.D., Rulfs, J.X., Kohles, S.S., and Bonassar, L.J. Comparison of chondrogensis in static and perfused bioreactor culture. Biotechnol Prog 16, 893, 2000.
3. Yeatts, A.B., and Fisher J.P. Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress. Bone 48, 171, 2011.
4. Godara, P., McFarland, C.D., and Nordon, R.E. Design of bioreactors for mesenchymal stem cell tissue engineering. J Chem Technol Biotechnol 83, 408, 2008.
5. Abousleiman, R.I., and Sikavitsas, V.I. Bioreactors for tissues of the musculoskeletal system. Tissue Eng 585, 243, 2006.
6. Bancroft, G.N., Sikavitsas, V.I., and Mikos, A.G. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng 9, 549, 2003.
7. Sikavitsas, V.I., Bancroft, G.N., Holtorf, H.L., Jansen, J.A., and Mikos, A.G. Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces. Proc Natl Acad Sci USA 100, 14683, 2003.
8. Chu, C.R., Szczodry, M., and Bruno, S. Animal models for cartilage regeneration and repair. Tissue Eng Part B Rev 16, 105, 2010.
9. Peattie R., and Fisher, R.J. Perfusion effects and hydrodynamics. Adv Biochem Eng Biotechnol 103, 75, 2007.
10. Liao, J.H., Guo, X.A., Nelson, D., Kasper, F.K., and Mikos A.G. Modulation of osteogenic properties of biodegradable polymer/extracellular matrix scaffolds generated with a flow perfusion bioreactor. Acta Biomater 6, 2386, 2010.
11. Liao, J.H., Guo, X.A., Grande-Allen, K.J., Kasper, F.K., and Mikos, A.G. Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering. Biomaterials 31, 8911, 2010.
12. Hu, J.C., and Athanasiou, K.A. Low-density cultures of bovine chondrocytes: effects of scaffold material and culture system. Biomaterials 26, 2001, 2005.
13. Darling, E.M., and Athanasiou, K.A. Articular cartilage bioreactors and bioprocesses. Tissue Eng 9, 9, 2003.