Absorptive capacity and openness of small biopharmaceutical firms - a European Union-United States comparison

R and D Management

Volumn 43, Issue 4, 2013, Pages 333-351

  Xia, Tianjiao ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84881616930     PISSN: 00336807     EISSN: 14679310     Source Type: Journal    
DOI: 10.1111/radm.12017     Document Type: Article

References (144)

1. Acs, Z.J. and Audretsch, D.B. (1989) Patents as a measure of innovative activity. Kyklos, 42, 2, 171-180.
2. Allarakhia, M., Kilgour, D.M., and Fuller, D.J. (2010) Modelling the incentive to participate in open source biopharmaceutical innovation. R&D Management, 40, 1, 50-66.
3. Arora, A., Fosfuri, A., and Gambardella, A. (2001) Markets for Technology: The Economics of Innovation and Corporate Strategy. Cambridge, MA: MIT Press.
4. Bagchi-Sen, S., Lawton, H., and Hall, L. (2004) The US biotechnology industry: industry dynamics and policy. Environment and Planning C: Government and Policy, 22, 199-216.
5. Bains, W. (2006) What you give is what you get: investment in European biotechnology. Journal of Commercial Biotechnology, 12, 4, 274-283.
6. Baum, J.A.C., Calabrese, T., and Silverman, B.S. (2000) Don't go it alone: alliance network composition and startups' performance in Canadian biotechnology. Strategic Management Journal, 21, 267-294.
7. Becker, W. and Peters, J. (2000) Technological opportunities, absorptive capacities, and innovation. Paper presented at The Eighth International Joseph A. Schumpeter Society Conference, Manchester, July 2000.
8. Berkhout, G., Hartmann, D., and Trott, P. (2010) Connecting technological capabilities with market needs using a cyclic innovation model. R&D Management, 40, 474-490.
9. Bianchi, M., Campodall'Orto, S., Frattini, F., and Vercesi, P. (2010) Enabling open innovation in small and medium-sized enterprises: how to find alternative applications for your technologies. R&D Management, 40, 414-431.
10. Cantner, U. and Pyka, A. (1998) Absorbing technological spillovers: simulations in an evolutionary Framework. Industrial & Corporate Change, 7, 2, 369-397.
11. Cassiman, B. and Veugelers, R. (2006) In search of complementarity in innovation strategy: internal R&D and external knowledge acquisition. Management Science, 52, 1, 68-82.
12. du Chatenier, E., Verstegen, J.A.A.M., Biemans, H.J.A., Mulder, M., and Omta, O.S.W.F. (2010) Identification of competencies for professionals in open innovation teams. R&D Management, 40, 271-280.
13. Chesborough, H. (2003) Open Innovation: The New Imperative for Creating and Profiting from Technology. Boston, MA: Harvard Business School.
14. Chesborough, H. (2006) Open Innovation Models: How to Thrive in the New Innovation Landscape. Boston, MA: Harvard Business School Press.
15. Chiaroni, D., Chiesa, V., and Frattini, F. (2010) Unravelling the process from Closed to Open Innovation: evidence from mature, asset-intensive industries. R&D Management, 40, 222-245.
16. Cohen, W.M. and Levinthal, D.A. (1990) Absorptive capacity: a new perspective on learning and innovation. Administrative Science Quarterly, 35, 128-152.
17. Cooke, P. (2001) New economy innovation systems: biotechnology in Europe and the USA. Industry and Innovation, 8, 3, 267-289.
18. Cooke, P. (2004) Regional knowledge capabilities, embeddedness of firms and industry organisation: bioscience megacentres and economic geography. European Planning Studies, 12, 5, 625-641.
19. Cooke, P. (2005) Regionally asymmetric knowledge capabilities and open innovation Exploring 'Globalisation 2' - A new model of industry organisation. Research Policy, 34, 1128-1149.
20. Cooke, P. (2011) Growth Cultures: The Global Bioeconomy and Its Bioregions. London: Routledge.
21. Coombs, J.E., Mudambi, R., and Deeds, D.L. (2006) An examination of the investments in U.S. biotechnology firms by foreign and domestic corporate partners. Journal of Business Venturing, 21, 405-428.
22. Cyert, R.M. and March, J.G. (1963) A Behavioral Theory of the Firm. Englewood Cliffs, NJ: Prentice Hall.
23. Deeds, D.L. and Hill, C.W.L. (1996) Strategic alliances and the rate of new product development: an empirical study of entrepreneurial biotechnology firms. Journal of Business Venturing, 11, 1, 41-55.
24. Dimsdale, N. and Prevezer, M. (1994) Capital Markets and Corporate Governance. Oxford: Oxford University Press.
25. Dosi, G. (1982) Technological paradigms and technological trajectories. Research Policy, 11, 147-162.
26. Dowling, M. and Helm, R. (2006) Product development success through cooperation: a study of entrepreneurial firms. Technovation, 26, 483-488.
27. Duysters, G. and Lokshin, B. (2011) Determinants of alliance portfolio complexity and its effect on innovative performance of companies. Journal of Product Innovation Management, 28, 4, 570-585.
28. Dyer, J.H. and Singh, H. (1998) The relational view: cooperative strategy and source of inter-organizational competitive advantage. Academy of Management Review, 23, 4, 660-679.
29. Enkel, E. and Gassmann, O. (2010) Creative imitation: exploring the case of cross-industry innovation. R&D Management, 40, 256-270.
30. Ernst & Young. (2006) BeyondBorders - Global Biotechnology Report 2008. Palo Alto, CA: Ernst & Young LLP.
31. Ernst & Young. (2008) Beyond Borders - Global Biotechnology Report 2008. Palo Alto, CA: Ernst & Young LLP.
32. Ernst & Young. (2009) Beyond Borders - Global Biotechnology Report 2009. Palo Alto, CA: Ernst & Young LLP.
33. Ernst & Young. (2010) Beyond Borders - Global Biotechnology Report 2010. Palo Alto, CA: Ernst & Young LLP.
34. Ernst & Young. (2011) Beyond Borders - Global Biotechnology Report 2011. Palo Alto, CA: Ernst & Young LLP.
35. Escribano, A., Fosfuri, A., and Tribó, J.A. (2009) Managing external knowledge flows: the moderating role of absorptive capacity. Research Policy, 38, 96-105.
36. European Commission. (2010) Europe 2020 - A Strategy for Smart, Sustainable and Inclusive Growth. Brussels: European Commission.
37. Fabrizio, K. (2009) Absorptive capacity and the search for innovation. Research Policy, 38, 2, 255-267.
38. Faems, D., De Visser, M., Andries, P., and Van Looy, B. (2010) Technology alliance portfolios and financial performance: value-enhancing and cost-increasing effects of open innovation. Journal of Product Innovation Management, 27, 6, 785-796.
39. Fazeli, S. (2004) 2003: what lessons for European biotechnology? Journal of Commercial Biotechnology, 10, 4, 304-311.
40. Fazeli, S. (2005) The European biotech sector: could it achieve more? Journal of Commercial Biotechnology, 12, 1, 10-19.
41. Fosfuri, A. and Tribó, J.A. (2006) Exploring the antecedents of potential absorptive capacity and its impact on innovation performance. Omega, 36, 2, 173-187.
42. Freel, M.S. (2005) Patterns of innovation and skills in small firms. Technovation, 25, 123-134.
43. Frenz, M., Michie, J., and Oughton, C. (2004) Co-operation, innovation and firm's absorptive capacity. Working Paper No. 12, Birmingham.
44. Gassmann, O., Enkel, E., and Chesbrough, H. (2010) The future of open innovation. R&D Management, 40, 213-221.
45. George, G., Zahra, S.A., Wheatley, K.K., and Khan, R. (2001) The effects of alliance portfolio characteristics and absorptive capacity on performance: a study of biotechnology firms. Journal of High Technology Management Research, 12, 205-226.
46. Gerwin, D. (2004) Coordinating new product development in strategic alliances. The Academy of Management Review, 29, 2, 241-258.
47. Giesecke, S. (2000) The contrasting roles of government in the development of biotechnology industry in the US and Germany. Research Policy, 29, 205-223.
48. Gilsing, V. and Nooteboom, B. (2006) Exploration and exploitation in innovation systems: the case of pharmaceutical biotechnology. Research Policy, 35, 1-23.
49. Glass, A.J. and Saggi, K. (1998) International technology transfer and the technology gap. Journal of Development Economics, 55, 369-398.
50. Gomes-Casseres, B., Hagedoorn, J., and Jaffe, A.B. (2006) Do alliances promote knowledge flows? Journal of Financial Economics, 80, 5-33.
51. Gomez, J. and Vargas, P. (2009) The effect of financial constraints, absorptive capacity and complementarity on multiple process technologies. Research Policy, 38, 1, 106-119.
52. Griffith, R., Redding, S., and Van Reenan, J. (2003) R&D and absorptive capacity: theory and empirical evidence. Scandinavian Journal of Economics, 105, 1, 99-118.
53. Gupta, A.K., Smith, K.G., and Shalley, C.E. (2006) The interplay between exploration and exploitation. Academy Management Journal, 49, 4, 693-706.
54. Hewitt-Dundas, N. (2006) Resource and capability constraints to innovation in small and large plants. Small Business Economics, 26, 257-277.
55. Hey, J.D. (1982) Search for rules for search. Journal of Economic Behavior and Organization, 3, 65-81.
56. Hoang, H. and Rothaermel, F. (2005) The effect of general and partner-specific alliance experience on joint R&D project performance. Academy of Management Journal, 48, 2, 332-345.
57. Hoang, H. and Rothaermel, F.T. (2010) Leveraging internal and external experience: exploration, exploitation, and R&D project performance. Strategic Management Journal, 31, 734-758.
58. Howells, J., Gagliardi, D., and Malik, K. (2008) The growth and management of R&D outsourcing: evidence from UK pharmaceuticals. R&D Management, 38, 2, 205-219.
59. Huber, G.P. (1991) Organizational learning: the contributing processes and literatures. Organization Science, 2, 1, 88-115.
60. Hughes, B. and Wareham, J. (2010) Knowledge arbitrage in global pharma: a synthetic view of absorptive capacity and open innovation. R&D Management, 40, 324-343.
61. Ili, S., Albers, A., and Miller, S. (2010) Open innovation in the automotive industry. R&D Management, 40, 246-255.
62. Jaffe, A.B., Trajtenberg, M., and Fogarty, M.S. (2002) The meaning of patent citations: report on the NBER/Case-Western Reserve Survey of Patentees, In: Jaffe, A.B. and Trajtenberg, M. (eds.), Patents, Citations and Innovations: A Window on the Knowledge Economy. Cambridge, MA: MIT Press.
63. Jansen, J.J.P., Van Den Bosch, F.A.J., and Volberda, H.W. (2005) Managing potential and realized absorptive capacity: how do organizational antecedents matter? Academy of Management Journal, 48, 6, 999-1015.
64. Karamanos, A.G. (2012) Leveraging micro- and macro-structures of embeddedness in alliance networks for exploratory innovation in biotechnology. R&D Management, 42, 1, 71-89.
65. Kedia, B.L. and Bhagat, R.S. (1988) Cultural constrains on transfer of technology across nations: implications for research in international and comparative management. Academy of Management Review, 13, 559-571.
66. Keller, W. (1996) Absorptive capacity: on the creation and acquisition of technology in development. Journal of Development Economics, 49, 199-210.
67. Keupp, M.M. and Gassmann, O. (2009) Determinants and archetype users of open innovation. R&D Management, 39, 4, 331-341.
68. Khanna, T. (1996) Winner-take-all alliances. Harvard Business Working Paper.
69. Kim, C. and Song, J. (2007) Creating new technology through alliances: an empirical investigation of joint patients. Technovation, 27, 8, 461-470.
70. Kim, L. (1997) The dynamics of Samsung's technological learning in semiconductors. California Management Review, 39, 3, 86-100.
71. Kim, L. (1998) Crisis construction and organizational learning: capability building in catching-up at Hyundai Motor. Organization Science, 9, 506-521.
72. Kitson, M., Howells, J., Braham, R., and Westlake, S. (2009) The Connected University: Driving Recovery and Growth in the UK Economy. London: NESTA.
73. Knockaert, M., Clarysse, B., and Wright, M. (2010) The extent and nature of heterogeneity of venture capital selection behaviour in new technology-based firms. R&D Management, 40, 357-371.
74. Koza, M.P. and Lewin, A.Y. (1998) The co-evolution of strategic alliances. Organization Science, 9, 255-264.
75. Laursen, K. and Salter, A. (2006) Open for innovation: the role of openness in explaining innovation performance among UK manufacturing firms. Strategic Management Journal, 27, 2, 131-150.
76. Lavoie, B.F. and Sheldon, I.M. (2000) The source of comparative advantage in the biotechnology industry: a real options approach. Agribusiness, 16, 1, 56-67.
77. Leiponen, A. (2005) Skills and innovation. International Journal of Industrial Organization, 23, 303-323.
78. Lemarié, S., de Looze, M.A., and Mangematin, V. (2000) Strategies of European SMEs in biotechnology: the role of size, technology and market. Scientometrics, 47, 3, 541-560.
79. Levinthal, D.A. and March, J.G. (1981) A model of adaptive organizational search. Journal of Economic Behavior and Organization, 2, 307-333.
80. Lichtenthaler, U. (2009) Outbound open innovation and its effect on firm performance: examining environmental influences. R&D Management, 39, 4, 317-330.
81. Lichtenthaler, U. and Ernst, H. (2009) Opening up the innovation process: the role of technology aggressiveness. R&D Management, 39, 1, 38-54.
82. de Looze, M.A., Coronini, R., and Joly, P.B. (2001) A note on recent trends in Knowledge creation and appropriation through genomics: a scientometric analysis. International Journal of Biotechnology, 3, 1-2, 4-22.
83. Malo, S. and Norus, J. (2009) Growth dynamics of dedicated biotechnology firms in transition economies. Evidence from the Baltic countries and Poland. Entrepreneurship and Regional Development, 21, 5-6, 481-502.
84. March, J.G. (1988) Variable risk preference and adaptive aspirations. Journal of Economic Behavior and Organization, 9, 5-24.
85. March, J.G. (1991) Exploration and exploitation in organizational learning. Organization Science, 2, 71-87.
86. Mason, C.M. and Harrison, R.T. (2003) Closing the regional equity gap? A critique of the department of trade and industry's regional venture capital funds initiative. Regional Studies, 37, 8, 855-868.
87. Maurer, I. and Ebers, M. (2006) Dynamics of social capital and their performance implications: lessons from biotechnology start-ups. Administrative Science Quarterly, 51, 262-292.
88. McAdam, M., McAdam, R., Galbraith, B., and Miller, K. (2010) An exploratory study of Principal Investigator roles in UK university Proof-of-Concept processes: an Absorptive Capacity perspective. R&D Management, 40, 455-473.
89. Miller, J. (2004) Early development still driving CRO performance. Pharmaceutical technology (2003), 28, 9, 100-102.
90. Mowery, D.C., Oxley, J.E., and Silverman, B.S. (1996) Strategic alliances and interfirm knowledge transfer. Strategic Management Journal, 17, 77-91.
91. Newey, L.R. and Zahra, S.A. (2009) The evolving firm: how dynamic and operating capabilities interact to enable entrepreneurship. British Journal of Management, 20, 82-100.
92. Neyer, A.-K., Bullinger, A.C., and Moeslein, K.M. (2009) Integrating inside and outside innovators: a sociotechnical systems perspective. R&D Management, 39, 4, 410-419.
93. Nooteboom, B., Vanhaverbeke, W., Duysters, G., Gilsing, V., and Oord, A. (2007) Optimal cognitive distance and absorptive capacity. Research Policy, 36, 7, 1016-1034.
94. Oliver, C. (1990) Determinants of interorganisational relationships: integration and future directions. The Academy of Management Review, 15, 2, 241-265.
95. Organisation for Economic Co-operation and Development (OECD) (2003) Building Partnerships for Progress: Statistical Definition of Biotechnology. Paris, France.
96. Owen-Smith, J., Riccaboni, M., Pammolli, F., and Powell, W.W. (2002) A comparison of U.S. and European university-industry relations in the life sciences. Management Science, 48, 1, 24-43.
97. Park, G. and Park, Y. (2006) On the measurement of patent stock as knowledge indicators. Technology Forecasting and Social Change, 73, 793-812.
98. Podsakoff, P.M., MacKenzie, S.B., Lee, J.-Y., and Podsakoff, N.P. (2003) Common method bias in behavioral research: a critical review of the literature and recommended remedies. Journal of Applied Psychology, 88, 5, 879-903.
99. Powell, W.W. and Brantley, P. (1992) Competitive cooperation in biotechnology: learning through networks? Nohria, N. and Eccles, R.G. (eds), Networks and Organizations. Structure, Form and Action. Boston, MA: Harvard Business School Press. pp. 366-394.
100. Powell, W.W., Koput, K., and Smith-Doerr, L. (1996) Inter-organizational collaboration and the locus of innovation: networks of learning in biotechnology. Administrative Science Quarterly, 41, 116-145.
101. Prevezer, M. (2001) Ingredients in the early development of the U.S. biotechnology industry. Small Business Economics, 17, 1, 17-29.
102. Quintana-Garcia, C. and Benavides-Velasco, C.A. (2004) Cooperation, competition, and innovation capability: a panel data of European dedicated biotechnology firms. Technovation, 24, 927-938.
103. Rader, R.A. (2007) Biopharmaceutical Products in the US and European Markets. Rockville, MD: BioPlan Associates, Inc.
104. Radner, R. and Rothschild, M. (1975) On the allocation of effort. Journal of Economic Theory, 10, 358-376.
105. Riccaboni, M. and Moliterni, R. (2009) Managing technological transitions through R&D alliances. R&D Management, 39, 1, 124-135.
106. Rocha, F. (1999) Inter-firm technological cooperation: effects of absorptive capacity, firm-size and specialization. Economics of Innovation & New Technology, 8, 3, 253-271.
107. Rosenberg, N. (1982) Inside the Black Box: Technology and Economics. New York: Cambridge University Press.
108. Rothaermel, F.T. (2001) Complementary assets, strategic alliances, and incumbent's advantage: an empirical study of industry and firm effects in the biopharmaceutical industry. Research Policy, 30, 1235-1251.
109. Rothaermel, F.T. and Deeds, D.L. (2004) Exploration and exploitation alliances in biotechnology: a system of new product development. Strategic Management Journal, 25, 3, 201-221.
110. Rothwell, R. and Dodgson, M. (1991) External linkages and innovation in small and medium-sized enterprises. R&D Management, 21, 125-136.
111. Sampson, R.C. (2007) R&D alliances and firm performance: the impact of technological diversity and alliance organization on innovation. Academy of Management Journal, 50, 2, 364-386.
112. Sapienza, A.M. (1989) R&D collaboration as a global competitive tactic - biotechnology and the ethical pharmaceutical industry. R&D Management, 19, 4, 285-295.
113. Sapir, A. (2003) An agenda for a growing Europe - making the EU economic system deliver.
114. Schmidt, T. (2005) Absorptive capacity-one size fits all? A firm-level analysis of absorptive capacity for different kinds of knowledge. ZEW discussion paper No. 05-72.
115. Sen, F.K. and Egelhoff, W.G. (2000) Innovative capabilities of a firm and the use of technical alliances. IEEE Transaction on Engineering Management, 47, 2, 174-183.
116. Shan, W. (1990) An empirical analysis of organizational strategies by entrepreneurial high technology firms. Strategic Management Journal, 11, 2, 129-139.
117. Shan, W. and Song, J. (1997) Foreign direct investment and the sourcing of technological advantage: evidence from the biotechnology industry. Journal of International Business Studies, 28, 2, 267-284.
118. Shan, W., Walker, G., and Kogut, B. (1994) Interfirm cooperation and startup innovation in the biotechnology industry. Strategic Management Journal, 15, 5, 387-394.
119. Sharp, M. (1995) The science of nations: European multinationals and American biotechnology. Paper for The Foundation for Manufacturing and Industry, Institute of Civil Engineers, Mimpo Science Policy Research Unit, Sussex University, Brighton, UK.
120. Sieg, J.H., Wallin, M.W., and von Krogh, G. (2010) Managerial challenges in open innovation: a study of innovation intermediation in the chemical industry. R&D Management, 40, 281-291.
121. Sofka, W. and Grimpe, C. (2010) Specialized search and innovation performance - evidence across Europe. R&D Management, 40, 310-323.
122. Spender, J.C. (1996) Making knowledge the basis of a dynamic theory of the firm. Strategic Management Journal, 17, 45-62.
123. Stinchcombe, A. (1965) Social structure and organizations. In: March, J. (ed.), Handbook of Organizations. Chicago, IL: Rand McNally. pp. 142-193.
124. Stock, G.N., Greis, N.P., and Fischer, W.A. (2001) Absorptive capacity and new product development. Journal of High Technology Management Research, 12, 1, 77-91.
125. Storey, D.J. and Greene, F.J. (2010) Small Business and Entrepreneurship. Harlow, UK: Pearson Education Limited.
126. Streiffer, R. (2006) Academic freedom and academic-industry relationships in biotechnology. Kennedy Institute of Ethics Journal, 16, 2, 129-149.
127. Taplin, R. (2007) Innovation and Business Partnering in Japan, Europe and the United States. Abingdon, Oxon: Routledge.
128. Teece, D.J. (1986) Profiting from technological innovation: implications for integration, collaboration, licensing and public policy. Research Policy, 15, 6, 285-305.
129. Teece, D.J. (1992) Competition, cooperation, and innovation: organizational arrangements for regimes of rapid technological progress. Journal of Economic Behavior and Organization, 18, 1-25.
130. Teece, D.J., Pisano, G., and Shuen, A. (1997) Dynamic capabilities and strategic management. Strategic Management Journal, 18, 509-533.
131. Vega-Jurado, J., Gutiérrez-Gracia, A., and Fernández-de-Lucio, I. (2008) Analyzing the determinants of firm's absorptive capacity: beyond R&D. R&D Management, 38, 4, 392-405.
132. Veugelers, R. and Cassiman, B. (1999) Make and buy in innovation strategies: evidence from Belgian manufacturing firms. Research Policy, 28, 1, 63-80.
133. Vuong, Q. (1989) Likelihood ratio tests for model selection and non-nested hypotheses. Econometrica, 57, 307-333.
134. Weimer, D. and Vining, A. (2004) Policy Analysis: Concepts and Practice. Upper Saddle River, NJ: Prentice Hall.
135. Winter, S.G. (1971) Satisficing, selection and the innovating remnant. Quarterly Journal of Economics, 85, 237-261.
136. Wolter, K. (2003) Can the U.S. experience be repeated? The evolution of biotechnology in three European regions (mimeo). Germany: Duisburg University.
137. Wright, M., Lockett, A., Binks, M., and Clarysse, B. (2006) University spin-out companies and venture capital. Research Policy, 35, 4, 481-501.
138. Wright, M., Clarysse, B., Mustar, P., and Lockett, A. (2008) Academic Entrepreneurship in Europe. Cheltenham, UK: Edward Elgar.
139. Xia, T. and Roper, S. (2008) From capability to connectivity: absorptive capacity and exploratory alliances in biopharmaceutical firms: a US-Europe comparison. Technovation, 28, 11, 776-785.
140. Xia, T. and Roper, S. (2009) Worlds apart? A comparison of the NPD strategies of biopharmaceutical firms in Europe and the US. Industry and Innovation, 16, 593-612.
141. Zahra, S.A. (1996) Technology strategy and new venture performance: a study of corporate-sponsored and independent biotechnology ventures. Journal of Business Venturing, 11, 4, 289-322.
142. Zahra, S.A. and George, G. (2002) Absorptive capacity: a review, reconceptualization, and extension. Academy of Management Review, 27, 2, 185-203.
143. Zollo, M., Reuer, J.J., and Singh, H. (2002) Inter-organizational routines and performance in strategic alliances. Organization Science, 13, 6, 701-713.
144. Zucker, L.G., Darby, M.R., and Armstrong, J. (1998) Geographically localized knowledge: spillovers or markets? Economic Inquiry, 36, 65-86.