Expression of lung resistance-related protein, LRP, and multidrug resistance-related protein, MRP1, in normal human lung cells in long-term cultures

Archives of Toxicology

Volumn 79, Issue 10, 2005, Pages 600-609

  Lehmann, Thomas ^a,b   Torky, Abdel Rahman Wageeh ^a   Stehfest, Ekkehard ^a   Hofmann, Stefan ^a   Foth, Heidi ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUNG RESISTANCE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; AGED; ARTICLE; BRONCHUS; BRONCHUS MUCOSA; CONTROLLED STUDY; EXPLANT; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LUNG ALVEOLUS CELL; LUNG CANCER; LUNG PARENCHYMA; MALE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN STABILITY; REFERENCE VALUE; RNA ANALYSIS; TOPOGRAPHY;

ADULT; AGED; BRONCHI; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; EPITHELIAL CELLS; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TIME FACTORS; TISSUE CULTURE TECHNIQUES; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 26944488979     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0669-1     Document Type: Article

References (39)

1. Barrand MA , Heppell-Parton AC, Wright KA, Rabbitts PH, Twentyman PR (1994) A 190-kDa protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene. J Natl Cancer Inst 86:110-117
2. Borst P, Evers R, Kool M, Wijnholds J (2000) A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92:1295-1302
3. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654
4. Cui Y, Konig J, Buchholz JK, Spring H, Leier I, Keppler D (1999) Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55:929-937
5. Doyle LA, Gao Y, Yang W, Ross DD (1995) Characterization of a 95 kilodalton membrane glycoprotein associated with multidrug resistance. Int J Cancer 4(62):593-598
6. Flens MJ, Zaman GJ, van der Valk P, Izquierdo MA, Schroeijers AB, Scheffer GL, van der Groep P, de Haas M, Meijer CJ, Scheper RJ (1996) Tissue distribution of the multidrug resistance protein. Am J Pathol 148:1237-1247
7. Foth H (1995) Role of the lung in accumulation and metabolism of xenobiotic compounds - implications for chemically induced toxicity. Crit Rev Toxicol 25:165-205
8. Franklin WA, Folkvord JM, Varella-Garcia M, Kennedy T, Proudfoot S, Cook R, Dempsey EC, Helm K, Bunn PA, Miller YE (1996) Expansion of bronchial epithelial cell populations by in vitro culture of explants from dysplastic and histologically normal sites. Am J Respir Cell Mol Biol 15:297-304
9. Gottesman MM (2002) Mechanisms of cancer drug resistance. Ann Rev Med 53:615-627
10. Hipfner DR, Deeley RG, Cole SPC (1999) Structural, mechanistic a clinical aspects of MRP1. Biochim Biophys Acta 1461:276-359
11. Hirohashi T, Suzuki H, Sugiyama Y (1999) Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J Biol Chem 274:15181-15185
12. Ishikawa T (1992) The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 17:463-468
13. Ishikawa T, Onishi Y, Hirano H, Oosumi K, Nagakura M, Tarui S (2004) Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1). Biol Pharm Bull 27:939-948
14. Izquierdo MA, Van der Zee AGJ, Vermorken JB, Van der Valk P, Beliën JAM, Giaccone G, Scheffer GL, Flens MJ, Pinedo HM, Kenemans P, Meijer CJLM, De Vries EGE, Scheper RJ (1995) Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma. J Natl Cancer Inst 87:1230-1237
15. Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJ, van der Valk P, Scheper RJ (1996b) Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am J Pathol 148:877-887
16. Izquierdo MA, Shoemaker RH, Flens MJ, Scheffer GL, Wu L, Prather TR, Scheper RJ (1996a) Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines. Int J Cancer 65:230-237
17. Jantsch B (1998) Aufbau einer gekoppelten reverse transkription/ polymerase Kettenreaktion für den Nachweis der Boten-Ribonukleinsäure des "Multidrug-Resistance-Gens" mdr1. Dissertation Universität Leipzig, p 81
18. Kedersha NL, Heuser JE, Chugani DC, Rome LH (1991) Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry. J Cell Biol 112:225
19. Kickhoefer VA, Rajavel KS, Scheffer GL, Dalton WS, Scheper RJ, Rome LH (1998) Vaults are up-regulated in multidrug-resistant cancer cell lines. J Biol Chem 273:8971-8974
20. Kool M, van der Linden M, de Haas M, Scheffer GL, de Vree JM, Smith AJ, Jansen G, Peters GJ, Ponne N, Scheper RJ, Elferink RP, Baas F, Borst P (1999) MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci USA 96:6914-6919
21. Kruh GD, Belinsky MG (2003) The MRP1 family of drug efflux pumps. Oncogene 22:7537-7552
22. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680-685
23. Lehmann T, Kohler C, Weidauer E, Taege C, Foth H (2001) Expression of MRP1 and related transporters in human lung cells in culture. Toxicology 5(167):59-72
24. Leonard GD, Fojo T, Bates SE (2003) The role of ABC transporters in clinical practice. Oncologist 8:411-424
25. List AF, Spier CS, Grogan TM, Johnson C, Roe DJ, Greer JP, Wolff SN, Broxterman HJ, Scheffer GL, Scheper RJ, Dalton WS (1996) Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 87:2464
26. McAleer C, Breen MA, White NL, Matthews N (1999) pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in huma embryonic kidney 293 cells. J Biol Chem 274:23541-23548
27. Qian YM, Song WC, Cui H, Cole SP, Deeley RG (2001) Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. J Biol Chem 276:6404-6411
28. Rao VV, Dehlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, Piwnica-Worms D (1999) Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebro-spinal-fluid drug-permeability barrier. Proc Natl Acad Sci USA 96:3900-3905
29. Rome LH, Kedersha NL, Chugani DC (1991) Unlocking vaults: organelles in search of a function. Trends Cell Biol 1:47-50
30. Scheffer GL, Wijngaard PLJ, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer C, Clevers HC, Scheper RJ (1995) The drug resistance-related protein LRP is the human major vault protein. Nat Med 1:578-582
31. Scheper RJ, Broxterman HJ, Scheffer GL, Kaaijk P, Dalton WS, van Heijningen TH, van Kalken CK, Slovak ML, de Vries EG, van der Valk P (1993) Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein- mediated multidrug resistance. Cancer Res 53:1475-1479
32. Schroeijers AB, Scheffer GL, Reurs AW, Pijnenborg AC, Abbondanza C, Wiemer EA, Scheper RJ (2001) Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies. J Histochem Cytochem 49:1379-1385
33. Stein U, Walther W, Laurencot CM, Scheffer GL, Scheper RJ, Shoemakered RH (1997) Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP. J Natl Cancer Inst 89:807-813
34. Stride BD, Valdimarsson G, Gerlach JH, Wilson GM, Cole SP, Deeley RG (1996) Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. Mol Pharmacol 49:962-971
35. Sugawara I, Akiyama S, Scheper RJ, Itoyama S (1997) Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP1. Cancer Lett 112:23-31
36. Taipalensuu J, Tornblom H, Lindberg G, Einarsson C, Sjoqvist F, Melhus H, Garberg P, Sjostrom B, Lundgren B, Artursson P (2001) Correlation of gene expression often drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J Pharmacol Exp Ther 299:164-170
37. Torky ARW, Stehfest E, Viehweger K, Taege C, Foth H (2005) Immuno-histochemical detection of MRPs in human lung cells in culture. Toxicology 207:437-450
38. Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A (1990) Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. Nature 348:741-744
39. Wijnholds J, Scheffer GL, Vander Valk M, Beijnen JH, Scheper RJ, Borst P (1998) Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J Exp Med 188:797