Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography

Journal of Pharmaceutical Sciences

Volumn 100, Issue 9, 2011, Pages 4037-4043

  Sakamoto, Atsushi ^a,b   Matsumaru, Takehisa ^a   Ishiguro, Naoki ^a   Schaefer, Olaf ^a   Ohtsuki, Sumio ^b   Inoue, Tae ^b   Kawakami, Hirotaka ^b   Terasaki, Tetsuya ^b  

^a NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; LC MS MS; Mass spectrometry; Membrane transporter; Multiplexed MRM quantification of proteins; Nano LC; Proteomics; Transporters; UDP glucuronosyltransferases

Indexed keywords

CYTOCHROME P450; GLUCURONOSYLTRANSFERASE;

ARTICLE; CELL MEMBRANE; FREEZE THAWING; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER; MEMBRANE; MICROSOME MEMBRANE; MONITORING; MULTIPLEXED MULTIPLE REACTION MONITORING; PROTEIN ANALYSIS; RELIABILITY; TANDEM MASS SPECTROMETRY; VALIDITY;

EID: 79960136330     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22591     Document Type: Article

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