Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression

European Journal of Clinical Pharmacology

Volumn 58, Issue 5, 2002, Pages 357-365

  Sy, Sherwin K ^a   Ciaccia, Antonio ^a   Li, Wei ^a   Roberts, Eve A ^b   Okey, Allan ^a   Kalow, Werner ^a   Tang, Bing Kou ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

CYP3A4; Gene expression; Testosterone

Indexed keywords

CYTOCHROME P450 3A4; MESSENGER RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME LOCALIZATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HISTOGRAM; HUMAN; HUMAN TISSUE; HYDROXYLATION; IMMUNOBLOTTING; INFANT; LIVER MICROSOME; MALE; MICHAELIS CONSTANT; NORMAL DISTRIBUTION; NORMAL HUMAN; PHENOTYPE; POPULATION DISTRIBUTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DETERMINATION; RNA TRANSLATION; SCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CYTOCHROME P-450 ENZYME SYSTEM; DATA INTERPRETATION, STATISTICAL; FEMALE; GENE EXPRESSION; HUMANS; INFANT; KINETICS; LIVER; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTOSTERONE;

EID: 0036377091     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-002-0487-9     Document Type: Article

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