Advancements in high throughput biophysical technologies: Applications for characterization and screening during early formulation development of monoclonal antibodies

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 696-707

  Samra, Hardeep S ^a   He, Feng ^b  

^a MEDIMMUNE   (United States)

^b AMGEN INC   (United States)

Author keywords

biophysical technology; formulation development; high throughput; monoclonal antibody

Indexed keywords

MACROGOL; MONOCLONAL ANTIBODY;

AFFINITY CHROMATOGRAPHY; CAPILLARY ELECTROPHORESIS; COLLOID; DIFFERENTIAL SCANNING CALORIMETRY; DIFFERENTIAL SCANNING FLUORIMETRY; DIFFUSION; DRUG FORMULATION; DRUG SOLUBILITY; EXTRINSIC FLUORESCENCE SPECTROSCOPY; FLUORESCENCE SPECTROSCOPY; FLUOROMETRY; HIGH THROUGHPUT SCREENING; HYDRODYNAMICS; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; HYDROPHOBICITY; INTRINSIC FLUORESCENCE SPECTROSCOPY; ISOTHERMAL TITRATION CALORIMETRY; LIGHT SCATTERING; OPTICAL DENSITY; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW; STATIC LIGHT SCATTERING; THERMOSTABILITY; TURBIDITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

ANTIBODIES, MONOCLONAL; BIOPHYSICS; BIOTECHNOLOGY; IMMUNOCHEMISTRY;

EID: 84859319265     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200404c     Document Type: Review

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