Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy

Neurobiology of Aging

Volumn 34, Issue 11, 2013, Pages 2585-2603

  Rusmini, Paola ^a,b   Crippa, Valeria ^a,b   Giorgetti, Elisa ^a,b   Boncoraglio, Alessandra ^a,b   Cristofani, Riccardo ^a,b   Carra, Serena ^c   Poletti, Angelo ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Androgen receptor; CAG repeat; Chaperones; HspB8; Motoneuron; Motoneuron disease; Neurodegeneration; Polyglutamine; Protein misfolding; Spinal and bulbar muscular atrophy

Indexed keywords

ANDROGEN RECEPTOR; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN B8; POLYGLUTAMINE; PROTEASOME; PROTEIN P62; TESTOSTERONE; TREHALOSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL AGGREGATION; CELL VIABILITY; CLEARANCE; CONTROLLED STUDY; KENNEDY DISEASE; MOTONEURON; MOUSE; MUTANT; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANDROGEN RECEPTOR; CAG REPEAT; CHAPERONES; HSPB8; MOTONEURON; MOTONEURON DISEASE; NEURODEGENERATION; POLYGLUTAMINE; PROTEIN MISFOLDING; SPINAL AND BULBAR MUSCULAR ATROPHY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENINE; ANIMALS; AUTOPHAGY; CELL LINE, TRANSFORMED; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HEAT-SHOCK PROTEINS; HSP20 HEAT-SHOCK PROTEINS; HUMANS; LEUPEPTINS; MICE; MOTOR NEURONS; MUSCLE PROTEINS; MUTATION; RECEPTORS, ANDROGEN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TESTOSTERONE; TREHALOSE;

EID: 84881542917     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.05.026     Document Type: Article

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