Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 11, 2013, Pages 5142-5156

  Piplani, Honit ^a   Rana, Chandan ^a   Vaish, Vivek ^a,c   Vaiphei, Kim ^b   Sanyal, S N ^a  

^a PANJAB UNIVERSITY   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^c University of Missouri   (United States)

Author keywords

AKT; Celecoxib; Dolastatin; Egr 1; Molecular docking; PI3 K

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CELECOXIB; CYCLIN D1; DOLASTATIN 15; EARLY GROWTH RESPONSE FACTOR 1; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAD; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT;

MOLLUSCA; RATTUS;

AKT; CELECOXIB; DOLASTATIN; EGR-1; MOLECULAR DOCKING; PI3-K;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BINDING SITES; CELL CYCLE PROTEINS; COLONIC NEOPLASMS; CYCLOOXYGENASE 2 INHIBITORS; DEPSIPEPTIDES; DOWN-REGULATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 84881540059     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.07.011     Document Type: Article

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