NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer

Molecular and Cellular Biochemistry

Volumn 378, Issue 1-2, 2013, Pages 47-64

  Vaish, Vivek ^a   Piplani, Honit ^a   Rana, Chandan ^a   Vaiphei, Kim ^b   Sanyal, Sankar Nath ^a  

^a PANJAB UNIVERSITY   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

EGR 1; Mitochondrial membrane potential; Molecular docking; NAG 1; NSAIDs; Reactive oxygen species

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CELECOXIB; EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA; NSAID ACTIVATED GENE 1; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; SULINDAC; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; BCL2L1 PROTEIN, RAT; CYCLOOXYGENASE 2 INHIBITOR; EGR1 PROTEIN, RAT; GDF15 PROTEIN, RAT; GROWTH DIFFERENTIATION FACTOR 15; PROTEIN BCL X; PYRAZOLE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL NUCLEUS; CHEMOPROPHYLAXIS; COLORECTAL CANCER; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; GENE ACTIVATION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR BIOLOGY; MOLECULAR DOCKING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COLON; COLORECTAL TUMOR; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY;

ANIMALIA; RATTUS;

1,2-DIMETHYLHYDRAZINE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; COLON; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2 INHIBITORS; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION; GROWTH DIFFERENTIATION FACTOR 15; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR DOCKING SIMULATION; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SULFONAMIDES; SULINDAC;

EID: 84886794476     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1593-y     Document Type: Article

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