Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5)

Carcinogenesis

Volumn 26, Issue 11, 2005, Pages 1905-1913

  Jung, Eun Mi ^a   Lee, Tae Jin ^a   Park, Jong Wook ^a   Choi, Kyeong Sook ^b   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CURCUMIN; DEATH RECEPTOR 5; MESSENGER RNA; PEROXIREDOXIN; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CURCUMA LONGA; DRUG POTENTIATION; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KIDNEY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SENSITIZATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, HEPATOCELLULAR; CASPASES; COLONIC NEOPLASMS; CURCUMIN; CYSTINE; CYTOCHROMES C; DRUG COMBINATIONS; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; LUCIFERASES; MEMBRANE GLYCOPROTEINS; PEROXIDASES; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 27744609173     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi167     Document Type: Article

References (44)

1. Mehta,K., Pantazis,P., McQueen,T. and Aggarwal,B.B. (1997) Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs, 8, 470-481.
2. Huang,M.T., Smart,R.C., Wong,C.Q. and Conney,A.H. (1988) Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res., 48, 5941-5946.
3. Huang,M.T., Ma,W., Lu,Y.P., Chang,R.L., Fisher,C., Manchand,P.S., Newmark,H.L. and Conney,A.H. (1995) Effects of curcumin, demethoxy-curcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Carcinogenesis, 16, 2493-2497.
4. Huang,M.T., Ma,W., Yen,P., Xie,J.G., Han,J., Frenkel,K., Grunberger,D. and Conney,A.H. (1997) Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis, 18, 83-88.
5. Huang,M.T., Lou,Y.R., Ma,W., Newmark,H.L., Reuhl,K.R. and Conney,A.H. (1994) Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res., 54, 5841-5847.
6. Kelloff,G.J., Boone,C.W., Crowell,J.A., Steele,V.E., Lubet,R. and Sigman,C.C. (1994) Chemopreventive drug development: Perspectives and progress. Cancer Epidemiol. Biomarkers Prev., 3, 85-98.
7. Somasundaram,S., Edmund,N.A., Moore,D.T., Small,G.W., Shi,Y.Y. and Orlowski,R.Z. (2002) Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res., 62, 3868-3875.
8. Jaiswal,A.S., Marlow,B.P., Gupta,N. and Narayan,S. (2002) Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene, 21, 8414-8427.
9. Bhaumik,S., Anjum,R., Rangaraj,N., Pardhasaradhi,B.V. and Khar,A. (1999) Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett., 456, 311-314.
10. Woo,J.H., Kim,Y.H., Choi,Y.J. et al. (2003) Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis, 24, 1199-1208.
11. Kehrer,J.P. (1993) Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol., 23, 21-48.
12. Shiraishi,F., Curtis,L.M., Truong,L., Poss,K., Visner,G.A., Madsen,K., Nick,H.S. and Agarwal,A. (2000) Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am. J. Physiol. Renal Physiol., 278, F726-F736.
13. Amato,R.J. (2000) Chemotherapy for renal cell carcinoma. Semin. Oncol., 27, 177-186.
14. Zhang,X.D., Nguyen,T., Thomas,W.D., Sanders,J.E. and Hersey,P. (2000) Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types. FEBS Lett., 482, 193-199.
15. Dejosez,M., Ramp,U., Mahotka,C., Krieg,A., Walczak,H., Gabbert,H.E. and Gerharz,C.D. (2000) Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. Cell Death Differ., 7, 1127-1136.
16. Srivastava,R.K. (2001) TRAIL/Apo-2L: Mechanisms and clinical applications in cancer. Neoplasia, 3, 535-546.
17. Pan,G., O'Rourke,K., Chinnaiyan,A.M., Gentz,R., Ebner,R., Ni,J. and Dixit,V.M. (1997) The receptor for the cytotoxic ligand TRAIL. Science, 276, 111-113.
18. Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science, 277, 815-818.
19. Ashkenazi,A. and Dixit,V.M. (1999) Apoptosis control by death and decoy receptors. Curr. Opin. Cell. Biol., 11, 255-260.
20. Sheridan,J.P., Marsters,S.A., Pitti,R.M. et al. (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science, 277, 818-821.
21. Ozoren,N., Fisher,M.J., Kim,K., Liu,C.X., Genin,A., Shifman,Y., Dicker,D.T., Spinner,N.B., Lisitsyn,N.A. and El-Deiry,W.S. (2000) Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance. Int. J. Oncol., 16, 917-925.
22. Wang,S. and El-Deiry,W.S. (2003) TRAIL and apoptosis induction by TNF-family death receptors. Oncogene, 22, 8628-8633.
23. Ivanov,V.N., Bhoumik,A. and Ronai,Z. (2003) Death receptors and melanoma resistance to apoptosis. Oncogene, 22, 3152-3161.
24. Benov,L., Sztejnberg,L. and Fridovich,I. (1998) Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic. Biol. Med., 25, 826-831.
25. LeBel,C.P., Ischiropoulos,H. and Bondy,S.C. (1992) Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol., 5, 227-231.
26. Kim,Y.H., Park,J.W., Lee,J.Y. and Kwon,T.K. (2004) Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. Carcinogenesis, 25, 1813-1820.
27. Jin,Z., McDonald,E.R., Dicker,D.T. and El-Deiry,W.S. (2004) Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J. Biol. Chem., 279, 35829-35839.
28. Thompson,C.B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456-1462.
29. Jacobson,M.D. (1996) Reactive oxygen species and programmed cell death. Trends Biochem. Sci., 21, 83-86.
30. Deneke,S.M. (2000) Thiol-based antioxidants. Curr. Top Cell Regul., 36, 151-180.
31. Rhee,S.G., Kang,S.W., Netto,L.E., Seo,M.S. and Stadtman,E.R. (1999) A family of novel peroxidases, peroxiredoxins. Biofactors, 10, 207-209.
32. Wood,Z.A., Schroder,E., Robin,H.J. and Poole,L.B. (2003) Structure, mechanism and regulation of peroxiredoxins. Trends Biochem. Sci., 28, 32-40.
33. Johnstone,R.W., Ruefli,A.A. and Lowe,S.W. (2002) Apoptosis: A link between cancer genetics and chemotherapy. Cell, 108, 153-164.
34. Martelli,A.M., Tazzari,P.L., Tabellini,G., Bortul,R., Billi,A.M., Manzoli,L., Ruggeri,A., Conte,R. and Cocco,L. (2003) A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells. Leukemia, 17, 1794-1805.
35. Shankar,S. and Srivastava,R.K. (2004) Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: Mechanisms and clinical implications. Drug Resist. Updat., 7, 139-156.
36. Thome,M., Schneider,P., Hofmann,K. et al. (1997) Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature, 386, 517-521.
37. Griffith,T.S., Chin,W.A., Jackson,G.C., Lynch,D.H. and Kubin,M.Z. (1998) Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J. Immunol., 161, 2833-2840.
38. Scaffidi,C., Schmitz,I., Krammer,P.H. and Peter,M.E. (1999) The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem., 274, 1541-1548.
39. Deeb,D., Xu,Y.X., Jiang,H., Gao,X., Janakiraman,N., Chapman,R.A. and Gautam,S.C. (2003) Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Mol. Cancer Ther., 2, 95-103.
40. Deeb,D., Jiang,H., Gao,X., Hafner,M.S., Wong,H., Divine,G., Chapman,R.A., Dulchavsky,S.A. and Gautam,S.C. (2004) Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation. Mol. Cancer Ther., 3, 803-812.
41. Simon,H.U., Haj-Yehia.A. and Levi-Schaffer,F. (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis, 5, 415-418.
42. Kim,H., Lee,T.H., Park,E.S., Suh,J.M., Park,S.J., Chung,H.K., Kwon,O.Y., Kim,Y.K., Ro,H.K. and Shong,M. (2000) Role of peroxiredoxins in regulating intracellular hydrogen peroxide and hydrogen peroxide-induced apoptosis in thyroid cells. J. Biol. Chem., 275, 18266-18270.
43. Shoba,G., Joy,D., Joseph,T., Majeed,M., Rajendran,R. and Srinivas,P.S. (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med., 64, 353-356
44. Sharma,R.A., McLelland,H.R., Hill,K.A., Ireson,C.R., Euden,S.A. Manson,M.M., Pirmohamed,M., Marnett,L.J., Gescher,A.J. and Steward,W.P. (2001) Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin. Cancer Res., 7, 1894-1900.