Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular signal-regulated kinase/Sp1-dependent DR5 upregulation and NF-κB inactivation

Molecular Cancer Therapeutics

Volumn 9, Issue 6, 2010, Pages 1583-1595

  Moon, Dong Oh ^a   Kim, Mun Ock ^b   Choi, Yung Hyun ^c   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Dong Eui University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BUTEIN; CHIMERIC ANTIBODY; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYLCYSTEINYLASPARAGINYLPROLYLARGINYLGLYCYLASPARTYL(O METHYLTYROSYL)ARGINYLCYSTEINAMIDE CYCLIC 1,9 DISULFIDE; REACTIVE OXYGEN METABOLITE; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1;

APOPTOSIS; ARTICLE; CELL TYPE; CELL VIABILITY; CONTROLLED STUDY; DNA FLANKING REGION; DRUG MECHANISM; DRUG SENSITIZATION; ENZYME ACTIVATION; HEPATOMA CELL; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; NF-KAPPA B; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 77953460056     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0942     Document Type: Article

References (40)

1. Havell EA, Fiers W, North RJ. The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity. J Exp Med 1998;167:1067-85.
2. Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104:155-62.
3. Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999;5:157-63.
4. Almasan A, Ashkenazi A. Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev 2003;3-4:337-48.
5. Bodmer JL, Holler N, Reynard S, et al. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2000;2:241-3.
6. Li H, Zhu H, Xu C, Yuan J. Cleavage of BID by caspase-8 mediates the mitochondria damage in the Fas pathway of apoptosis. Cell 1998;94:491-501. (Pubitemid 28391865)
7. Srivastava RK. TRAIL/Apo-2L: mechanisms and clinical applications in cancer. Neoplasia 2001;3:535-46.
8. Inoue S, Twiddy D, Dyer MJ, Cohen GM. Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis. Cell Death Differ 2006;13:2160-2. (Pubitemid 44742701)
9. Koschny R, Ganten TM, Sykora J, et al. TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology 2007;45:649-58. (Pubitemid 46450616)
10. Ganten TM, Koschny R, Haas TL, et al. Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL. Hepatology 2005;42:588-59. (Pubitemid 41233651)
11. Wu GS, Burns TF, McDonald ER III, et al. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 1997;17:141-3.
12. Sheikh MS, Burns TF, Huang Y, et al. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor. Cancer Res 1998;58:1593-8. (Pubitemid 28215076)
13. Guan B, Yue P, Clayman GL, Sun SY. Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene. J Cell Physiol 2001;188:98-105. (Pubitemid 32476500)
14. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 2003;66:1022-37.
15. Kim NY, Pae HO, Oh GS, et al. Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol Toxicol 2001;88:261-6.
16. Iwashita K, Kobori M, Yamaki K. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci Biotechnol Biochem 2000;64:1813-20.
17. Wang Y, Chan FL, Chen S, Leung LK. The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. Life Sci 2005;77:39-51. (Pubitemid 40546375)
18. Yit CC, Das NP. Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett 1994;82:65-72. (Pubitemid 24211073)
19. Jang HS, Kook SH, Son YO, et al. Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim Biophys Acta 2005;1726:309-16.
20. Lee SH, Seo GS, Kim HS, Woo SW, Ko G, Sohn DH. 2′,4′, 6′-Tris (methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway. Biochem Pharmacol 2006;72:1322-33.
21. Kim YH, Park JW, Lee JY, Kwon TK. Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. Carcinogenesis 2004;25:1813-20.
22. Sun M, Zhang J, Liu S, Liu Y, Zheng D. Sp1 is involved in 8-chloroadenosine-upregulated death receptor 5 expression in human hepatoma cells. Oncol Rep 2008;19:177-85. (Pubitemid 351176147)
23. http://www.scioncorp.com.
24. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001;104:487-501. (Pubitemid 32201945)
25. Shen HM, Liu ZG. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 2006;40:928-39.
26. Yoshida T, Maeda A, Tani N, Sakai T. Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene. FEBS Lett 2001;507:381-5. (Pubitemid 33030270)
27. Chu S, Ferro TJ. Sp1, regulation of gene expression by phosphorylation. Gene 2005;348:1-11. (Pubitemid 40410011)
28. de Lamirande E, Gagnon C. Involvement of the extracellular signal regulated protein kinase pathway in human sperm function; involvement of the superoxide anion. Mol Hum Reprod 2002;8:124-35. (Pubitemid 34144972)
29. Nagata S. Apoptosis by death factor. Cell 1997;88:355-65.
30. Thorburn A. Death receptor-induced cell killing. Cell Signal 2004;16:139-44.
31. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and Krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 2001;188:143-60. (Pubitemid 32622905)
32. Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 2005;26:1905-13.
33. Kim H, Kim EH, Eom YW, et al. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res 2006;66:1740-50.
34. Higuchi H, Grambihler A, Canbay A, Bronk SF, Gores GJ. Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1. J Biol Chem 2004;279:51-60. (Pubitemid 38044798)
35. Moon DO, Kim MO, Choi YH, Hyun JW, Chang WY, Kim GY. Butein induces G2/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. Cancer Lett 2010;299:204-13.
36. Barkett M, Gilmore TD. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 1999;18:6910-24.
37. Ravi R, Bedi GC, Engstrom LW, et al. Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB. Nat Cell Biol 2001;3:409-16. (Pubitemid 32288449)
38. Pandey MK, Sandur SK, Sung B, Sethi G, Kunnumakkara AB, Aggarwal BB. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-κB and NF-κB-regulated gene expression through direct inhibition of IκBα kinase β on cysteine 179 residue. J Biol Chem 2007;282:17340-50.
39. Braeuer SJ, Büneker C, Mohr A, Zwacka RM. Constitutively activated nuclear factor-κB, but not induced NF-κB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells. Mol Cancer Res 2006;4:715-28. (Pubitemid 44683312)
40. Wang CY,Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS, Jr. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998;281:1680-3.