Dermal absorption and hydrolysis of methylparaben in different vehicles through intact and damaged skin: Using a pig-ear model in vitro

Food and Chemical Toxicology

Volumn 59, Issue , 2013, Pages 754-765

  Pažoureková, Silvia ^a   Hojerová, Jarmila ^a   Klimová, Zuzana ^a   Lucová, Marianna ^b  

^a SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

^b INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

Author keywords

Hydrolysis; In vitro dermal absorption; Intact and damaged pig ear skin; Metabolism; Metylparaben; Permeation enhancer

Indexed keywords

4 HYDROXYBENZOIC ACID; COSMETIC; METHYL PARABEN; SKINCARE PRODUCT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EAR; EMULSION; FREEZING; HYDROGEL; HYDROLYSIS; IN VITRO STUDY; METABOLISM; NONHUMAN; SAFETY; SKIN; SKIN ABSORPTION; SKIN INJURY; SWINE;

AD; ANOVA; APPLIED DOSE; BELOW THE LIMIT OF QUANTIFICATION; BLOQ; BP; BUTYLPARABEN; CIR; E; ENHANCER; EP; ETHYLPARABEN; EU SCIENTIFIC COMMITTEE ON CONSUMER SAFETY; FDA; FOOD AND DRUG ADMINISTRATION; FTS; FULL-THICKNESS SKIN MEMBRANE; HYDROLYSIS; IN VITRO DERMAL ABSORPTION; INTACT AND DAMAGED PIG-EAR SKIN; J(SS); LIMIT OF DETECTION; LIMIT OF QUANTIFICATION; LOD; LOQ; METABOLISM; METHYLPARABEN; METYLPARABEN; MP; OECD; ONE-WAY ANALYSIS OF VARIANCE; ORGANIZATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; P; P-HYDROXYBENZOIC ACID; PERMEABILITY COEFFICIENT; PERMEATION ENHANCER; PG; PHBA; PP; PROPYLENE GLYCOL; PROPYLPARABEN; RECEPTOR FLUID; RF; SC; SCCS; SD; SED; STANDARD DEVIATION; STEADY STATE FLUX; STRATUM CORNEUM; SYSTEMIC EXPOSURE DOSAGE; TC; TEC; TRANSCUTANEOUS ELECTRICAL CONDUCTIVITY; TRANSCUTOL® CG; UNMETABOLISED MP; UNMMP; UR; UREA; US COSMETIC INGREDIENT REVIEW;

ABATTOIRS; ADMINISTRATION, CUTANEOUS; ANIMALS; BIOTRANSFORMATION; CRYOPRESERVATION; DERMATOLOGIC AGENTS; EAR; EMULSIONS; FEMALE; HUMANS; HYDROGEL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; PARABENS; PHARMACEUTICAL VEHICLES; PRESERVATIVES, PHARMACEUTICAL; SKIN; SKIN ABSORPTION; SUS SCROFA;

EID: 84881493418     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.07.025     Document Type: Article

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