Skin permeation of parabens in excised guinea pig dorsal skin, its modification by penetration enhancers and their relationship with n- octanol/water partition coefficients

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 8, 1997, Pages 1354-1357

  Kitagawa, Shuji ^a   Li, Hui ^a   Sato, Shinji ^a  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

Author keywords

Fluidity; L menthol; N dodecyl 2 pyrrolidone; Paraben; Penetration enhancer; Skin penetration

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; OCTANOL; WATER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; GUINEA PIG; LIPID BILAYER; NONHUMAN; PARTITION COEFFICIENT; SKIN PERMEABILITY; STRATUM CORNEUM;

EID: 0030881710     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.1354     Document Type: Article

References (20)

1. Walters K. A., "Transdermal Drug Delivery," ed. by Hadgraft J., Guy R. H., Marcel Dekker, New York, 1989, pp. 197-246.
2. Phillips C. A., Michniak B. B., J. Pharm. Sci., 84, 1427-1433 (1995)
3. Williams A. C., Barry B. W., Pharm. Res., 8, 17-24 (1991).
4. Walker R. B., Smith E. W., Advanced Drug Delivery Reviews, 18, 295-301 (1996).
5. Kitagawa S., Yokochi N., Murooka N., Int. J. Pharm., 126, 49-56 (1995)
6. Kitagawa S., Sawada M., Hirata H., Int. J. Pharm., 98, 203-208 (1993)
7. Kitagawa S., Kametani F., Tsuchiya K., Sakurai H., Biochim. Biophys. Acta, 1027, 123-129 (1990).
8. Itoh T., Xia J., Magavi R., Nishihata T., Rytting J. H., Pharm. Res., 7, 1042-1047 (1990).
9. Obata Y., Takayama K., Machida Y., Nagai T., Drug Des. and Discovery, 8, 137-144 (1991).
10. Sugibayashi K., Kobayashi D., Nakagaki E., Hatanaka T., Inoue N., Kusumi S., Kobayashi M., Kimura M., Morimoto Y., Int. J. Pharm., 113, 189-197 (1995).
11. Hatanaka T., Shimoyama M., Sugibayashi K., Morimoto Y., Yakuzaigaku, 52, 215-223 (1992).
12. Baker E. J., Hadgraft J., Pharm. Res., 12, 993-997 (1995).
13. Sato S., Hirotani Y., Ogura N., Kitagawa S., Chem. Pharm. Bull., submitted.
14. Hashida M., Yamashita F., "Percutaneous Penetration Enhancers," ed. by Smith E. W., Maibach H. I., CRC Press, Boca Raton, 1995, pp. 309-321.
15. Anderson B. D., Higuchi W. I., Raykar P. V., Pharm. Res., 5, 566-573 (1988).
16. Ghanem A. H., Mahmoud H., Higuchi W. I., Rohr U. D., Borsadia S., Liu P., Fox J. L., Good W. R., J. Controlled Release, 6, 75-83 (1987).
17. Obata Y., Takayama K., Maitani Y., Machida Y., Nagai T., Int. J. Pharm., 89, 191-198 (1993).
18. Megrab N. A., Williams A. C., Barry B. W., Int. J. Pharm., 116, 101-112 (1995).
19. Koyama Y., Bando H., Yamashita F., Takakura Y., Sezaki H., Hashida M., Pharm. Res., 11, 377-383 (1994).
20. Valvani S. C., Yalkowski S. H., "Physical Chemical Properties of Drugs," ed. by Yalkowski S. H., Sinkula A. A., Valvani S. C., Marcel Dekker, New York, 1980, pp. 201-229.