Partitioning of parabens between phases of submicron emulsions stabilized with egg lecithin

International Journal of Pharmaceutics

Volumn 312, Issue 1-2, 2006, Pages 174-178

  Watrobska Swietlikowska, Dorota ^a   Sznitowska, Malgorzata ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Emulsion; Lecithin; Parabens; Preservatives

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; LIPOSOME; METHYL PARABEN; PHOSPHATIDYLCHOLINE; PROPYL PARABEN; SOYBEAN OIL;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; DRUG FORMULATION; EMULSION; LIPOPHILICITY; MICELLE; PRIORITY JOURNAL; ULTRACENTRIFUGATION; ULTRAFILTRATION;

CHEMISTRY, PHARMACEUTICAL; EGGS; EMULSIONS; PARABENS; PHOSPHATIDYLCHOLINES; PRESERVATIVES, PHARMACEUTICAL; SOLUBILITY;

EID: 33645031808     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.01.005     Document Type: Article

References (16)

1. C.B. Anger, D. Rupp, P. Lo, and H. Takruri Preservation of dispersed systems H.A. Lieberman M.M. Rieger G.S. Banker Pharmaceutical Dosage Forms: Disperse Systems vol. 1 1996 Marcel Dekker New York 377 435
2. S. Benita, and M.Y. Levy Submicron emulsions as colloidal drug carriers for intravenous administration: comprehensive physicochemical characterization J. Pharm. Sci. 82 1993 1069 1079
3. J. Férézou, A. Gulik, N. Domingo, F. Milliat, J.C. Dedieu, S. Dunel-Erb, C. Chevalier, and A.C. Bach Intralipid 10%: physicochemical characterization Nutrition 17 2001 930 933
4. M.J. Groves, and C.J. Herman The redistribution of bulk aqueous phase phospholipids during thermal stressing of phospholipid-stabilized emulsions J. Pharm. Pharmacol. 45 1993 592 596
5. J. Han, and C. Washington Partition of antimicrobial additives in an intravenous emulsion and their effect on emulsion physical stability Int. J. Pharm. 288 2005 263 271
6. C.J. Herman, and M.J. Groves The influence of free fatty acid formation on the pH of phospholipid-stabilized triglyceride emulsions Pharm. Res. 10 1993 774 776
7. M. Jumaa, F.H. Furkert, and B.W. Müller A new lipid emulsion formulation with high antimicrobial efficacy using chitosan Eur. J. Pharm. Biopharm. 53 2002 115 123
8. T.R.R. Kurup, L.S.C. Wan, and L.W. Chan Preservative requirements in emulsion Pharm. Acta Helv. 62 1992 204 208
9. T.J. McCarthy Formulated factors affecting the activity of preservatives J.J. Kabara Cosmetic and Drug Preservation. Principles and Practice 1984 Marcel Dekker New York 359 388
10. N. Pongcharoenkiat, G. Narsimhan, R.T. Lyons, and S.L. Hem The effect of surface charge and partition coefficient on the chemical stability of solutes in o/w emulsion J. Pharm. Sci. 91 2002 559 570
11. T. Shimamoto, and H. Mima A model for the evaluation and prediction of preservative activity in oil-in-water emulsions Chem. Pharm. Bull. 27 1979 2743 2750
12. M. Sznitowska, S. Janicki, E. Dabrowska, and M. Gajewska Screening of antimicrobial agents as potential preservatives for submicron emulsions Eur. J. Pharm. Sci. 15 2002 489 495
13. H. Teixeira, C. Dubernet, V. Rosilio, S. Benita, J. Lepault, I. Erk, and P. Couvreur New bicompartmental structures are observed when stearylamine is mixed with triglyceride emulsions Pharm. Res. 17 2000 1329 1332
14. L.S.C. Wan, T.R.R. Kurup, and L.W. Chan Partition of preservatives in oil/water systems Pharm. Acta Helv. 61 1986 308 313
15. K. Westesen, and T. Wehler Physicochemical characterization of a model intravenous oil-in-water emulsion J. Pharm. Sci. 81 1992 777 786
16. X. Zhang, and L. Kirsch The physical stability of thermally-stressed phospholipid-based emulsions containing methyl, propyl and heptyl parabens as model drugs Int. J. Pharm. 265 2003 133 140