Systemic exposure to parabens: Pharmacokinetics, tissue distribution, excretion balance and plasma metabolites of [ 14C]-methyl-, propyl- and butylparaben in rats after oral, topical or subcutaneous administration

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 445-454

  Aubert, Nicolas ^a   Ameller, Thibault ^a   Legrand, Jean Jacques ^a  

^a SOLVO BIOTECHNOLOGY   (Hungary)

Author keywords

ADME; Bioavailability; Extravascular routes; Para hydroxybenzoic acid; Parabens; Rats

Indexed keywords

BUTYL PARABEN; METHYL PARABEN; PROPYL PARABEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; FEMALE; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; URINARY EXCRETION;

ANIMALS; AREA UNDER CURVE; DRUG ADMINISTRATION ROUTES; FEMALE; MALE; PARABENS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

MAMMALIA; RATTUS;

EID: 84857959660     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.12.045     Document Type: Article

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