Nicotinamide Adenine Dinucleotide (NAD+) Repletion Attenuates Bupivacaine-Induced Neurotoxicity

Neurochemical Research

Volumn 38, Issue 9, 2013, Pages 1880-1894

  Zheng, Ting ^a   Xu, Shi Yuan ^a   Zhou, Shu Qin ^a   Lai, Lu Ying ^a   Li, Le ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Bupivacaine; Energy metabolism; NAD+; Neurotoxicity

Indexed keywords

BUPIVACAINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; REACTIVE OXYGEN METABOLITE;

ANALYSIS OF VARIANCE; APOPTOSIS; ARTICLE; CATALYSIS; CELL DEATH; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG EXPOSURE; FLOW CYTOMETRY; GLYCOLYSIS; HUMAN; HUMAN CELL; MEDICAL PROCEDURES; MEMBRANE DEPOLARIZATION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN MODIFICATION; PROTEIN REPLETION;

BUPIVACAINE; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; LIDOCAINE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NAD; REACTIVE OXYGEN SPECIES;

EID: 84881481613     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1094-0     Document Type: Article

References (48)

1. Perez-Castro R, Patel S, Garavito-Aguilar ZV, Rosenberg A, Recio-Pinto E, Zhang J, Blanck TJJ, Xu F (2009) Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg 108(3):997-1007. doi: 10.1213/ane.0b013e31819385e1
2. Ma R, Wang X, Lu C, Li C, Cheng Y, Ding G, Liu L, Ding Z (2010) Dexamethasone attenuated bupivacaine-induced neuron injury in vitro through a threonine-serine protein kinase B-dependent mechanism. Neuroscience 167(2):329-342. doi: 10.1016/j.neuroscience.2009.12.049
3. Lu J, Xu SY, Zhang QG, Xu R, Lei HY (2011) Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways. Eur J Pharmacol 657(1-3):51-58. doi: 10.1016/j.ejphar.2011.01.055
4. Lirk P, Haller I, Peter H, Lang L, Tomaselli B, Klimaschewski L, Gerner P (2008) In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity. Anesth Analg 106(5):1456-1464. doi: 10.1213/ane.0b013e318168514b
5. Park CJ, Park SA, Yoon TG, Lee SJ, Yum KW, Kim HJ (2005) Bupivacaine induces apoptosis via ROS in the schwann cell line. J Dent Res 84(9):852-857. doi: 10.1177/154405910508400914
6. Johnson ME, Saenz JA, DaSilva AD, Uhl CB, Gores GJ (2002) Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model. Anesthesiology 97(6):1466-1476
7. + consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med 11(1):28-42. doi: 10.1007/s12017-009-8058-1
8. Mattson MP, Liu D (2002) Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders. Neuromolecular Med 2(2):215-231. doi: 10.1385/nmm:2:2:215
9. Sasaki Y, Vohra BPS, Lund FE, Milbrandt J (2009) Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. J Neurosci 29(17):5525-5535. doi: 10.1523/jneurosci.5469-08.2009
10. Wang J (2005) A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol 170(3):349-355. doi: 10.1083/jcb.200504028
11. + depletion and mitochondrial permeability transition. J Biol Chem 279(18):18895-18902. doi: 10.1074/jbc.M313329200
12. Araki T (2004) Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305(5686):1010-1013. doi: 10.1126/science.1098014
13. +/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal 10(2):179-206. doi: 10.1089/ars.2007.1672
14. Kim SH, Lu HF, Alano CC (2011) Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS ONE 6(3):e14731. doi: 10.1371/journal.pone.0014731
15. + depletion is necessary and sufficient for Poly(ADP-Ribose) polymerase-1-mediated neuronal death. J Neurosci 30(8):2967-2978. doi: 10.1523/jneurosci.5552-09.2010
16. Kaundal RK, Shah KK, Sharma SS (2006) Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sci 79(24):2293-2302. doi: 10.1016/j.lfs.2006.07.034
17. + depletion protects neurons against excitotoxicity. Ann N Y Acad Sci 1147(1):275-282. doi: 10.1196/annals.1427.028
18. Yan T, Feng Y, Zheng J, Ge X, Zhang Y, Wu D, Zhao J, Zhai Q (2010) Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int 56(1):101-106. doi: 10.1016/j.neuint.2009.09. 007
19. + profoundly decreases brain injury in a rat model of transient focal ischemia. Front Biosci 12:2728-2734
20. Pillai VB, Sundaresan NR, Kim G, Gupta M, Rajamohan SB, Pillai JB, Samant S, Ravindra PV, Isbatan A, Gupta MP (2010) Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. J Biol Chem 285(5):3133-3144. doi: 10.1074/jbc.M109.077271
21. Wang J, He Z (2009) NAD and axon degeneration: from the Wlds gene to neurochemistry. Cell Adh Migr 3(1):77-87
22. + repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem Biophys Res Commun 308(4):809-813. doi: 10.1016/s0006-291x(03)01483-9
23. Zong WX (2004) Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18(11):1272-1282. doi: 10.1101/gad.1199904
24. Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL (2006) Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci 103(48):18314-18319. doi: 10.1073/pnas. 0606528103
25. D'Amours D, Desnoyers S, D'Silva I, Poirier GG (1999) Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 342(Pt 2):249-268
26. Virag L, Szabo C (2002) The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54(3):375-429
27. Beilin Y, Halpern S (2010) Ropivacaine versus bupivacaine for epidural labor analgesia. Anesth Analg 111(2):482-487. doi: 10.1213/ANE.0b013e3181e3a08e
28. Chan VW, Peng P, Chinyanga H, Lazarou S, Weinbren J, Kaszas Z (2000) Determining minimum effective anesthetic concentration of hyperbaric bupivacaine for spinal anesthesia. Anesth Analg 90(5):1135-1140
29. Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z (2005) A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol 170(3):349-355. doi: 10.1083/jcb.200504028
30. Xie HR, Hu LS, Li GY (2010) SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. Chin Med J (Engl) 123(8):1086-1092
31. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184(1):39-51
32. Span LF, Pennings AH, Vierwinden G, Boezeman JB, Raymakers RA, de Witte T (2002) The dynamic process of apoptosis analyzed by flow cytometry using Annexin-V/propidium iodide and a modified in situ end labeling technique. Cytometry 47(1):24-31
33. Wang S, Xing Z, Vosler PS, Yin H, Li W, Zhang F, Signore AP, Stetler RA, Gao Y, Chen J (2008) Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced dna repair. Stroke 39(9):2587-2595. doi: 10.1161/strokeaha.107.509158
34. Unami A, Shinohara Y, Ichikawa T, Baba Y (2003) Biochemical and microarray analyses of bupivacaine-induced apoptosis. J Toxicol Sci 28(2):77-94
35. Lu J, Xu SY, Zhang QG, Lei HY (2011) Bupivacaine induces reactive oxygen species production via activation of the amp-activated protein kinase-dependent pathway. Pharmacology 87(3-4):121-129. doi: 10.1159/000323402
36. Eruslanov E, Kusmartsev S (2010) Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol 594:57-72. doi: 10.1007/978-1-60761- 411-1-4
37. Salido M, Gonzalez JL, Vilches J (2007) Loss of mitochondrial membrane potential is inhibited by bombesin in etoposide-induced apoptosis in PC-3 prostate carcinoma cells. Mol Cancer Ther 6(4):1292-1299. doi: 10.1158/1535-7163.mct-06-0681
38. Fakler M, Loeder S, Vogler M, Schneider K, Jeremias I, Debatin KM, Fulda S (2009) Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood 113(8):1710-1722. doi: 10.1182/blood-2007-09-114314
39. Ciccarone V, Spengler BA, Meyers MB, Biedler JL, Ross RA (1989) Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. Cancer Res 49(1):219-225
40. Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL (2002) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297(5579):259-263. doi: 10.1126/science.1072221
41. Ying W, Sevigny MB, Chen Y, Swanson RA (2001) Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proc Natl Acad Sci 98(21):12227-12232. doi: 10.1073/pnas.211202598
42. Olek RA, Ziolkowski W, Kaczor JJ, Greci L, Popinigis J, Antosiewicz J (2004) Antioxidant activity of NADH and its analogue: an in vitro study. J Biochem Mol Biol 37(4):416-421
43. Quintana-Cabrera R, Bolanos JP (2013) Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria. Biochem Soc Trans 41(1):106-110. doi: 10.1042/BST20120252
44. Shi F, Li Y, Li Y, Wang X (2009) Molecular properties, functions, and potential applications of NAD kinases. Acta Biochim Biophys Sin 41(5):352-361. doi: 10.1093/abbs/gmp029
45. Zhang H, Forman HJ (2012) Glutathione synthesis and its role in redox signaling. Semin Cell Dev Biol 23(7):722-728. doi: 10.1016/j.semcdb.2012.03.017
46. Lu SC (2009) Regulation of glutathione synthesis. Mol Aspects Med 30(1-2):42-59. doi: 10.1016/j.mam.2008.05.005
47. + availability and proteotoxicity. Neuromolecular Med 11(2):97-100. doi: 10.1007/s12017-009-8069-y
48. Desai KM, Wu L (2008) Free radical generation by methylglyoxal in tissues. Drug Metabol Drug Interact 23(1-2):151-173