Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways

European Journal of Pharmacology

Volumn 657, Issue 1-3, 2011, Pages 51-58

  Lu, Jun ^a   Xu, Shi Yuan ^a   Zhang, Qing Guo ^a   Xu, Rui ^a   Lei, Hong Yi ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bupivacaine; Mitochondrion; p38 MAPK

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; BUPIVACAINE; CHLORIDE CHANNEL; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; VOLTAGE DEPENDENT ANION CHANNEL;

APOPTOSIS; ARTICLE; CELL VIABILITY; CHLORIDE TRANSPORT; CONTROLLED STUDY; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANESTHETICS, LOCAL; ANIMALS; APOPTOSIS; BISBENZIMIDAZOLE; BUPIVACAINE; CELL LINE; CHLORIDES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PYRIDINES; REACTIVE OXYGEN SPECIES;

EID: 79952489552     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.01.055     Document Type: Article

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