Antitumour and free radical scavenging effects of γ-mangostin isolated from Garcinia mangostana pericarps against hepatocellular carcinoma cell

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 9, 2013, Pages 1419-1428

  Chang, Hui Fang ^a   Wu, Chih Hsiung ^b   Yang, Ling Ling ^a,c,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

apoptosis; Garcinia mangostana; liver cancer cell; mitochondria; reactive oxygen species

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2',7' DICHLOROFLUORESCEIN DIACETATE; 3,3' DIHEXYLOXACARBOCYANINE; ANTINEOPLASTIC AGENT; GAMMA MANGOSTIN; PLANT MEDICINAL PRODUCT; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; REAGENT; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CATALYSIS; CELL STRAIN HEPG2; CELLULAR PARAMETERS; CONTROLLED STUDY; DIPLOIDY; DRUG ISOLATION; DRUG STRUCTURE; FLOW CYTOMETRY; GARCINIA MANGOSTANA; GIEMSA STAIN; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; NUCLEAR CONDENSATION; OXIDATIVE STRESS; PERICARP; PHYTOCHEMISTRY; RAT; TISSUE INJURY;

EID: 84881475633     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12111     Document Type: Article

References (42)

1. El-Serag HB,. Hepatocellular carcinoma. N Engl J Med 2011; 365: 1118-1127.
2. Yeo W, et al. A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J Natl Cancer Inst 2005; 97: 1532-1538. (Pubitemid 41631953)
3. Ogawa T, et al. Role of reactive oxygen in synthetic estrogen induction of hepatocellular carcinomas in rats and preventive effect of vitamins. Carcinogenesis 1995; 16: 831-836.
4. Zhang W, et al. Vitamin intake and liver cancer risk: a report from two cohort studies in china. J Natl Cancer Inst 2012; 104: 1174-1182.
5. Chiang KC, et al. Hepatocellular carcinoma and vitamin D: a review. J Gastroenterol Hepatol 2011; 26: 1597-1603.
6. Zhao Y, et al. Effects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury. Eur J Pharmacol 2005; 509: 195-200. (Pubitemid 40279078)
7. Paradis V, et al. In situ detection of lipid peroxidation by-products in chronic liver diseases. Hepatology 1997; 26: 135-142. (Pubitemid 27280317)
8. Lee LF, et al. Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). J Biol Chem 1998; 273: 28253-28260.
9. Sheppard BC, et al. Effects of paclitaxel on the growth of normal, polyposis, and cancerous human colonic epithelial cells. Cancer 1999; 85: 1454-1464. (Pubitemid 29152816)
10. Rajabalian S,. Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines. Exp Oncol 2008; 30: 133-138. (Pubitemid 351951390)
11. Chin YW, et al. Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (mangosteen). Phytochemistry 2008; 69: 754-758.
12. Shibata MA, et al. Alpha-mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med 2011; 9: 69.
13. Chang HF, Yang LL,. Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells. Molecules 2012; 17: 8010-8021.
14. Chang HF, et al. Apoptotic effects of gamma-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells. Molecules 2010; 15: 8953-8966.
15. Balunas MJ, et al. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod 2008; 71: 1161-1166.
16. Akao Y, et al. Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci 2008; 9: 355-370. (Pubitemid 351482120)
17. Chen SX, et al. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med 1996; 62: 381-382.
18. Chairungsrilerd N, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996; 62: 471-472. (Pubitemid 26370346)
19. Chen LG, et al. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol 2008; 46: 688-693.
20. Alley MC, et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 1988; 48: 589-601. (Pubitemid 18056527)
21. Lee HH, et al. Neuroprotection and free radical scavenging effects of Osmanthus fragrans. J Biomed Sci 2007; 14: 819-827.
22. Chen YC, et al. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. Arch Toxicol 2002; 76: 351-359.
23. Chow JM, et al. Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells. J Cell Biochem 2008; 103: 1394-1404.
24. Ancerewicz J, et al. Structure-property relationships of trimetazidine derivatives and model compounds as potential antioxidants. Free Radic Biol Med 1998; 25: 113-120. (Pubitemid 28285278)
25. Pinto MM, et al. Xanthone derivatives: new insights in biological activities. Curr Med Chem 2005; 12: 2517-2538. (Pubitemid 41408417)
26. Chairungsrilerd N, et al. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha- methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol 1998; 123: 855-862. (Pubitemid 28085385)
27. Kakiuchi N, et al. Studies on dental caries prevention by traditional medicines. VIII. Inhibitory effect of various tannins on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chem Pharm Bull (Tokyo) 1986; 34: 720-725. (Pubitemid 16141033)
28. Nakatani K, et al. Gamma-mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Mol Pharmacol 2004; 66: 667-674. (Pubitemid 39329266)
29. Yamakuni T, et al. Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells. Neurosci Lett 2006; 394: 206-210. (Pubitemid 43144851)
30. Jung HA, et al. Antioxidant xanthones from the pericarp of Garcinia mangostana (mangosteen). J Agric Food Chem 2006; 54: 2077-2082.
31. Doi H, et al. Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. Anticancer Res 2009; 29: 2485-2495.
32. Kondo M, et al. Bioavailability and antioxidant effects of a xanthone-rich mangosteen (Garcinia mangostana) product in humans. J Agric Food Chem 2009; 57: 8788-8792.
33. Stagos D, et al. Chemoprevention of liver cancer by plant polyphenols. Food Chem Toxicol 2012; 50: 2155-2170.
34. Bishayee A, et al. Dietary phytochemicals in the chemoprevention and treatment of hepatocellular carcinoma: in vivo evidence, molecular targets, and clinical relevance. Curr Cancer Drug Targets 2012; 12: 1191-1232.
35. Chao C, et al. CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells. Lab Invest 2012; 92: 420-436.
36. Jeon YK, et al. Promoter hypermethylation and loss of CD133 gene expression in colorectal cancers. World J Gastroenterol 2010; 16: 3153-3160.
37. Zhao R, et al. Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2. World J Gastroenterol 2011; 17: 1152-1159.
38. Chen YC, et al. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J Cell Physiol 1998; 177: 324-333.
39. Chen YC, et al. Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem Pharmacol 2002; 64: 1713-1724.
40. Chu YF, et al. Antioxidant and antiproliferative activities of common vegetables. J Agric Food Chem 2002; 50: 6910-6916.
41. Block G, et al. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 1992; 18: 1-29.
42. Temple NJ, Gladwin KK,. Fruit, vegetables, and the prevention of cancer: research challenges. Nutrition 2003; 19: 467-470. (Pubitemid 36444696)