The natural product cyclomarin kills mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease

Angewandte Chemie - International Edition

Volumn 50, Issue 26, 2011, Pages 5889-5891

  Schmitt, Esther K ^a   Riwanto, Meliana ^b   Sambandamurthy, Vasan ^b,d   Roggo, Silvio ^a   Miault, Charlotte ^a   Zwingelstein, Christian ^a   Krastel, Philipp ^a   Noble, Christian ^b   Beer, David ^b   Rao, Srinivasa P S ^b   Au, Melvin ^b   Niyomrattanakit, Pornwaratt ^b   Lim, Viviam ^b   Zheng, Jun ^b   Jeffery, Douglas ^c   Pethe, Kevin ^b   Camacho, Luis R ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Novartis Institutes for Tropical Diseases   (Singapore)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d ASTRAZENECA   (United Kingdom)

Author keywords

antibiotics; chemical proteomics; Clp protease complex; cyclic peptides; natural products

Indexed keywords

CYCLIC PEPTIDES; DRUG DISCOVERY; HIGH AFFINITY; MYCOBACTERIUM TUBERCULOSIS; NATURAL PRODUCTS; PROTEASE COMPLEX; REGULATORY SUBUNITS;

ANTIBIOTICS; CELL DEATH; MOLECULAR BIOLOGY;

PEPTIDES;

BACTERIAL PROTEIN; CLPC1 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; CYCLOMARIN A; HEAT SHOCK PROTEIN; OLIGOPEPTIDE; TUBERCULOSTATIC AGENT;

ARTICLE; CHEMISTRY; DRUG EFFECT; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; HEAT-SHOCK PROTEINS; MYCOBACTERIUM TUBERCULOSIS; OLIGOPEPTIDES; PROTEIN BINDING;

EID: 79959284189     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201101740     Document Type: Article

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