Crystal structure of a bifunctional deaminase and reductase from Bacillus subtilis involved in riboflavin biosynthesis

Journal of Biological Chemistry

Volumn 281, Issue 11, 2006, Pages 7605-7613

  Chen, Sheng Chia ^a   Chang, Yuan Chih ^a   Lin, Chao Hsiung ^a   Lin, Chun Hung ^b   Liaw, Shwu Huey ^a,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOSYNTHESIS; CRYSTAL STRUCTURE; DRUG THERAPY; ENZYME KINETICS; MONOMERS; RNA; SUBSTRATES;

ANTIMICROBIAL DRUGS; RIBOFLAVIN; TETRAMERIC STRUCTURE;

ENZYMES;

DEAMINASE; DIHYDROFOLATE REDUCTASE; FOLIC ACID; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOFLAVIN; ZINC ION; ALDEHYDE REDUCTASE; BACTERIAL PROTEIN; ION; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBG PROTEIN, BACILLUS SUBTILIS; ZINC;

ARTICLE; BACILLUS SUBTILIS; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL; RNA EDITING; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; METABOLISM; MOLECULAR GENETICS; PH; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS);

AMINO ACID SEQUENCE; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; IONS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NADP; NUCLEOTIDE DEAMINASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RIBOFLAVIN; SEQUENCE HOMOLOGY, AMINO ACID; STEREOISOMERISM; SUBSTRATE SPECIFICITY; SUGAR ALCOHOL DEHYDROGENASES; TETRAHYDROFOLATE DEHYDROGENASE; ZINC;

EID: 33646365634     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510254200     Document Type: Article

References (36)

1. Bacher, A., Eberhardt, S., Fischer, M., Kis, K., and Richter, G. (2000) Annu. Rev. Nutr. 20, 153-167
2. Oltmanns, O., and Bacher, A. (1972) J. Bacteriol. 110, 818-822
3. Burrows, R. B., and Brown, G. M. (1978) J. Bacteriol. 136, 657-667
4. Richter, G., Fischer, M., Krieger, C., Eberhardt, S., Lüttgen, H., Gerstenschläger, I., and Bacher, A. (1997) J. Bacteriol. 179, 2022-2028
5. Baur, A., Schaaff-Gerstenschlager, I., Boles, E., Miosga, T., Rose, M., and Zimmermann, F. K. (1993) Yeast 9, 289-293
6. Fisher, M., Romisch, W., Saller, S., Illarionov, B., Richter, G., Rohdich, F., Eisenreich, W., and Bacher, A. (2004) J. Biol. Chem. 279, 36299-36308
7. Graupner, M., Xu, H., and White, R. H. (2002) J. Bacteriol. 184, 1952-1957
8. Keegan, L. P., Leroy, A., Sproul, D., and O'Connell, M. A. (2004) Genome Biol. 5, 209-218
9. Harris, R. S., and Liddament, M. T. (2004) Nat. Rev. Immunol. 4, 868-877
10. Ko, T. P., Lin, J. J., Hu, C. Y., Hsu, Y. H., Wang, A. H. J., and Liaw, S. H. (2003) J. Biol. Chem. 278, 19111-19117
11. Liaw, S. H., Chang, Y. J., Lai, C. T., Chang, H. C., and Chang, G. G. (2004) J. Biol. Chem. 279, 35479-35485
12. Johansson, E., Mejlhede, N., Neuhard, J., and Larsen, S. (2002) Biochemistry 41, 2563-2570
13. Almog, R., Maley, F., Maley, G. F., Maccoll, R., and Van Roey, P. (2004) Biochemistry 43, 13715-13723
14. Kuratani, M., Ishii, R., Bessho, Y., Fukunaga, R., Sengoku, T., Shirouzu, M., Sekine, S., and Yokoyama, S. (2005) J. Biol. Chem. 280, 16002-16008
15. Kelley, L. A., MacCallum, R. M., and Sternberg, M. J. (2000) J. Mol. Biol. 299, 499-520
16. Kompis, I. M., Islam, K, and Then, R. L. (2005) Chem. Rev. 105, 593-620
17. Schuck, P., Perugini, M. A., Gonzales, N. R., Howlett, G. J., and Schubert, D. (2002) Biophys. J. 82, 1096-1111
18. Terwilliger, T. C. (2003) Methods Enzymol. 374, 22-37
19. Wang, J. W., Chen, J. R., Gu, Y. X., Zheng, C. D., Jiang, F., Fan, H. F., Terwilliger, T. C., and Hao, Q. (2004) Acta Crystallogr. Sect. D 60, 1244-1253
20. Dams, T., Auerbach, G., Bader, G., Jacob, U., Ploom, T., Huber, R., and Jaenicke, R. (2000) J. Mol. Biol. 297, 659-672
21. Roussel, A., and Cambillau, C. (1991) in Silicon Graphics Geometry Partners Directory 81, Silicon Graphics Corp., Mountain View, CA
22. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D 54, 905-921
23. Schäffer, A. A., Aravind, L., Madden, T. L., Shavirin, S., Spouge, J. L., Wolf, Y. I., Koonin, E. V., and Altschul, S. F. (2001) Nucleic Acids Res. 29, 2995-3005
24. Chenna, R., Sugawara, H., Koike, T., Lopez, R., Gibson, T. J., Higgins, D. G., and Thompson, J. D. (2003) Nucleic Acids Res. 31, 3497-3500
25. Esnouf, R.M. (1999) Acta Crystallogr. Sect. D 55, 938-940
26. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
27. Wallace, A. C., Laskowski, R. A., and Thornton, J. M. (1995) Protein Eng. 8, 127-134
28. Schnell, J. R., Dyson, H. J., and Wright, P. E. (2004) Annu. Rev. Biophys. Biomol. Struct. 33, 119-140
29. Wolan, D. W., Greasly, S. E., Beardsley, G. P., and Wilson, I. A. (2002) Biochemistry 41, 15505-15513
30. Navaratnam, N., Fujino, T., Bayliss, J., Jarmuz, A., How, A., Richardson, N., Somasekaram, A., Bhattacharya, S., Carter, C., and Scott, J. (1998) J. Mol. Biol. 275, 695-714
31. Xu, H., Svarovskaia, E. S., Barr, R., Zhang, Y., Khan, M. A., Strebel, K., and Pathak, V. K. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 5652-5657
32. Ta, V. T., Nagaoka, H., Catalan, N., Durandy, A., Fischer, A., Imai, K., Nonoyama, S., Tashiro, J., Ikegawa, M., Ito, S., Kinoshita, K., Muramatsu, M., and Honjo, T. (2003) Nat. Immunol. 4, 843-848
33. Elias, Y., and Huang, R. H. (2005) Biochemistry 44, 12057-12065
34. Dietmann, S., Park, J., Notredame, C., Heger, A., Lappe, M., and Holm, L. (2001) Nucleic Acids Res. 29, 55-57
35. Fierke, C. A., Johnson, K. A., and Benkovic, S. J. (1987) Biochemistry 26, 4085-4092
36. Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M. D., and Yuthavong, Y. (2003) Nat. Struct. Biol. 10, 357-365