Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons

Human Molecular Genetics

Volumn 21, Issue 5, 2012, Pages 1078-1089

  Sterky, Fredrik H ^a   Hoffman, Alexander F ^b   Milenkovic, Dusanka ^c   Bao, Betty ^b   Paganelli, Arianna ^a   Edgar, Daniel ^a   Wibom, Rolf ^a   Lupica, Carl R ^b   Olson, Lars ^a   Larsson, Nils Göran ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; GLUTAMATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX I DEFICIENCY; CONTROLLED STUDY; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; ELECTRON; ENZYME ACTIVITY; FEMALE; GENE DISRUPTION; GENE LOSS; HEART MUSCLE; HOMEOSTASIS; IN VIVO STUDY; INNERVATION; KNOCKOUT MOUSE; MESENCEPHALON; METABOLITE; MOUSE; NONHUMAN; OXIDATION; PARKINSON DISEASE; PRIORITY JOURNAL; STRIATE CORTEX; SUBSTANTIA NIGRA; TISSUE SPECIFICITY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CORPUS STRIATUM; DOPAMINE; DOPAMINERGIC NEURONS; ELECTRON TRANSPORT COMPLEX I; ENZYME STABILITY; HOMEOSTASIS; MESENCEPHALON; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIA, HEART; MPTP POISONING; MYOCARDIUM;

EID: 84856976662     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr537     Document Type: Article

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