Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5488-5502

  Hirayama, Takaharu ^a   Okaniwa, Masanori ^a   Imada, Takashi ^a   Ohashi, Akihiro ^a   Ohori, Momoko ^a   Iwai, Kenichi ^a   Mori, Kouji ^a   Kawamoto, Tomohiro ^a   Yokota, Akihiro ^a   Tanaka, Toshimasa ^a   Ishikawa, Tomoyasu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

4 Oxo 4,5 dihydrothieno 3,4 c pyridine 6 carboxamide; CENP E; Electrostatic potential map (EPM); Imidazo 1,2 a pyridine

Indexed keywords

10 (4 FLUOROPHENYL) 3,4 DIHYDRO 1H,6H THIENO[3',4':4,5]PYRIDO[2,1 C][1,4]OXAZINE 1,6 DIONE; 3 BROMO N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (4 FLUOROPHENYL) 4H THIENO[3,2 B]PYRROLE 5 CARBOXAMIDE; 3 BROMOTHIENO[3,2 B]PYRROLE; 3 CHLORO N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (4 FLUOROPHENYL) 4H THIENO[3,2 B]PYRROLE 5 CARBOXAMIDE; 3 CYANO N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (4 FLUOROPHENYL) 4H THIENO[3,2 B]PYRROLE 5 CARBOXAMIDE; 4 OXO 4,5 DIHYDROTHIENO[3,4 C]PYRIDINE 6 CARBOXAMIDE; 5 BROMO N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 3 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRIDINE 2 CARBOXAMIDE; 5 BROMOIMIDAZO[1,2 A]PYRIDINE; CENTROMERE PROTEIN E; ETHYL 3 (4 FLUOROPHENYL) 1 METHYL 1H INDOLE 2 CARBOXYLATE; ETHYL 3 (4 FLUOROPHENYL) 2 HYDROXY 3 [4 [(2 HYDROXYETHYL)CARBAMOYL] 3 THIENYL]ACRYLATE; ETHYL 3 [4 [[2 (DIMETHYLAMINO)ETHYL]CARBAMOYL] 3 THIENYL] 3 (4 FLUOROPHENYL) 2 HYDROXYACRYLATE; ETHYL 5 [2 (DIMETHYLAMINO)ETHYL] 7 (4 FLUOROPHENYL) 4 OXO 4,5 DIHYDROTHIENOL[3,4 C]PYRIDINE 6 CARBOXYLATE; ETHYL 7 (4 FLUOROPHENYL) 4 OXO 4H THIENO[3,4 C]PYRAN 6 CARBOXYLATE; ETHYL DIAZO(DIETHOXYPHOSPHORYL)ACETATE; GSK 923295A; HISTONE H3; N (3,4 DICHLOROBENZYL) 5 [2 (DIMETHYLAMINO)ETHYL] 7 (4 FLUOROPHENYL) N METHYL 4 OXO 4,5 DIHYDROTHIENO[3,4 C]PYRIDINE 6 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) 5 [3 (DIMETHYLAMINO)PROPYL] 7 (4 FLUOROPHENYL) N METHYL 4 OXO 4,5 DIHYDROTHIENO[3,4 C]PYRIDINE 6 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) 7 (4 FLUOROPHENYL) 5 (2 HYDROXYETHYL) N METHYL 4 OXO 4,5 DIHYDROTHIENO[3,4 C]PYRIDIN 6 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) 7 (4 FLUOROPHENYL) N,5 DIMETHYL 4 OXO 4,5 DIHYDROTHIENO[3,4 C]PYRIDINE 6 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 1 (4 FLUOROPHENYL) 3 METHYL 1H INDOLE 2 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 3 (4 FLUOROPHENYL) 1 METHYL 1H INDOLE 2 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (4 FLUOROPHENYL) 3 (TRIFLUOROMETHYL) 4H THIENO[3,2 B]PYRROLE 5 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (4 FLUOROPHENYL) 3 METHYL 4H THIENO[3,2 B]PYRROLE 5 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 4 (4 FLUOROPHENYL) 4 H THIENO[3,2 B]PYRROLE 5 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) N [2 (DIMETHYLAMINO)ETHYL] 7 (4 FLUOROPHENYL) 5 METHYL 4 OXO 4,5 DIHYDROTHIENO[3,4 C]PYRIDINE 6 CARBOXAMIDE; PROTEIN INHIBITOR; PYRIDINE DERIVATIVE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSTATIC POTENTIAL MAP; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

(1)H NMR; 4-OXO-4,5-DIHYDROTHIENO[3,4-C]PYRIDINE-6-CARBOXAMIDE; CENP-E; CENTROMERE-ASSOCIATED PROTEIN-E; DIFFERENTIAL SCANNING CALORIMETRY; DSC; ELECTROSTATIC POTENTIAL MAP; ELECTROSTATIC POTENTIAL MAP (EPM); EPM; IMIDAZO[1,2-A]PYRIDINE; PD; PHARMACODYNAMIC; PROTON NUCLEAR MAGNETIC RESONANCE; SAR; STRUCTURE-ACTIVITY RELATIONSHIP; ZATPRXWLTXOXAQ-UHFFFAOYSA-N;

AMIDES; BICYCLO COMPOUNDS; BINDING SITES; CHROMOSOMAL PROTEINS, NON-HISTONE; HELA CELLS; HISTONES; HUMANS; IMIDAZOLES; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881378409     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.067     Document Type: Article

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