Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 841-844

  Parmentier, Jean Gilles ^a   Portevin, Bernard ^a   Golsteyn, Roy M ^a   Pierré, Alain ^a   Hickman, John ^a   Gloanec, Philippe ^a   De Nanteuil, Guillaume ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

CHK1 inhibitor; Hymenialdisine

Indexed keywords

CHECKPOINT KINASE 1; HYMENIALDISINE DERIVATIVE; THIENO[3,2 B]PYRROLOAZEPINONE DERIVATIVE; THIOPHENE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; AZEPINES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTRONS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN KINASES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 58549114658     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.001     Document Type: Article

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