Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 542-559

  Grunewald, Gary L ^a   Seim, Mitchell R ^a   Bhat, Seema R ^a   Wilson, Marc E ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

4,5,6,7 Tetrahydrothieno 3,2 c pyridine; Enzyme inhibitors; Isosteric substitution; Phenylethanolamine N methyltransferase; Stacking interactions

Indexed keywords

4,5,6,7 TETRAHYDROTHIENO[3,2 C]PYRIDINE DERIVATIVE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; BENZYLAMINE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; PHENYLETHANOLAMINE N METHYLTRANSFERASE INHIBITOR; S ADENOSYLHOMOCYSTEINE; TETRAHYDROISOQUINOLINE DERIVATIVE; THIOPHENE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHIRALITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; SPRAGUE DAWLEY RAT; STRUCTURE ANALYSIS; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; PROTEIN BINDING; PYRIDINES; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 38049048188     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.066     Document Type: Article

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