Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: Triumph over adversity

Acta Crystallographica Section D: Biological Crystallography

Volumn 69, Issue 8, 2013, Pages 1433-1446

  Abuhammad, Areej ^a,b,c   Lowe, Edward D ^b   Mcdonough, Michael A ^a   Shaw Stewart, Patrick D ^d   Kolek, Stefan A ^d   Sim, Edith ^a,e   Garman, Elspeth F ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF JORDAN   (Jordan)

^d Douglas Instruments Ltd   (United Kingdom)

^e KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

arylamine N acetyltransferase; cholesterol catabolism; cross seeding; crystal microseeding; drug targets; microseed matrix screen; pseudo translational symmetry; tuberculosis; twinning

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; BACTERIAL PROTEIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CHOLESTEROL CATABOLISM; CROSS-SEEDING; CRYSTAL MICROSEEDING; CRYSTALLIZATION; DRUG TARGETS; ENZYME ACTIVE SITE; ENZYME STABILITY; ENZYMOLOGY; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; MICROSEED MATRIX SCREEN; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PSEUDO-TRANSLATIONAL SYMMETRY; SEQUENCE HOMOLOGY; SMALL ANGLE SCATTERING; TUBERCULOSIS; TWIN PREGNANCY; X RAY CRYSTALLOGRAPHY;

ARYLAMINE N-ACETYLTRANSFERASE; CHOLESTEROL CATABOLISM; CROSS-SEEDING; CRYSTAL MICROSEEDING; DRUG TARGETS; MICROSEED MATRIX SCREEN; PSEUDO-TRANSLATIONAL SYMMETRY; TUBERCULOSIS; TWINNING;

ARYLAMINE N-ACETYLTRANSFERASE; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; MODELS, MOLECULAR; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; SCATTERING, SMALL ANGLE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84881274762     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444913015126     Document Type: Article

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