Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism

Journal of Biological Chemistry

Volumn 285, Issue 1, 2010, Pages 434-443

  Lack, Nathan A ^a   Yam, Katherine C ^b   Lowe, Edward E ^a   Horsman, Geoff P ^b   Owen, Robin L ^c   Sim, Edith ^a   Eltis, Lindsay D ^b,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

^d NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

A-CARBON; ACTIVE SITE; CATABOLIC PATHWAY; CHOLESTEROL METABOLISM; CONFORMATIONAL CHANGE; DEGRADING ENZYMES; ENOLATES; ENZYMATIC MECHANISMS; HYDROLASES; INDUCED STRAIN; INTRACELLULAR SURVIVAL; META-CLEAVAGE; MYCOBACTERIAL; MYCOBACTERIUM TUBERCULOSIS; NUCLEOPHILIC ATTACK; RED-SHIFTED; SIDE CHAIN CARBON; SOLVENT MOLECULES; SYNTHETIC ANALOGUES; TAUTOMERIZATIONS;

ACIDS; AMINO ACIDS; CONFORMATIONS; ENZYMES; IMAGE STORAGE TUBES; OLEFINS; PHOSPHATASES;

CHOLESTEROL;

HYDROLASE;

ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME SPECIFICITY; GENETIC VARIABILITY; HYDROGEN BOND; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; BIOCATALYSIS; CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS, UNSATURATED; HYDROLASES; KINETICS; MODELS, BIOLOGICAL; MUTANT PROTEINS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, SECONDARY; SOLUTIONS; SPECTROPHOTOMETRY, ULTRAVIOLET; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; TORSION, MECHANICAL;

MYCOBACTERIUM TUBERCULOSIS;

EID: 73649123859     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.058081     Document Type: Article

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