Rational design of protein stability: Effect of (2S,4R)-4-fluoroproline on the stability and folding pathway of ubiquitin

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Crespo, Maria D ^a   Rubini, Marina ^b  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 FLUOROPROLINE; GUANIDINE; PROLINE DERIVATIVE; UBIQUITIN; UNCLASSIFIED DRUG; DRUG DERIVATIVE; FLUORINE; FLUORO PROLINE; FLUORO-PROLINE; PROLINE;

ARTICLE; AUXOTROPHY; CIRCULAR DICHROISM; CONTROLLED STUDY; ESCHERICHIA COLI; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; THERMOSTABILITY; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; HUMAN; METABOLISM;

ESCHERICHIA COLI;

CIRCULAR DICHROISM; DRUG DESIGN; FLUORINE RADIOISOTOPES; HUMANS; MODELS, MOLECULAR; PROLINE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; UBIQUITIN;

EID: 79956069864     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019425     Document Type: Article

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