Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1185-1190

  Fullam, Elizabeth ^a   Abuhammad, Areej ^a   Wilson, David L ^a   Anderton, Matthew C ^a   Davies, Steve G ^a   Russell, Angela J ^a   Sim, Edith ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Amino alcohols; Arylamine N acetyltransferase; Drug discovery; Enzyme inhibition; Tuberculosis

Indexed keywords

3 [3' (4'' CYCLOPENT 2''' EN 1''' YLPHENOXY) 2' HYDROXYPROPYL] 5,5 DIMETHYLIMIDAZOLIDINE 2,4 DIONE; ACYLTRANSFERASE; ACYLTRANSFERASE INHIBITOR; AMINOALCOHOL; BETA AMINOALCOHOL; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINO ALCOHOLS; ANTITUBERCULAR AGENTS; ARYLAMINE N-ACETYLTRANSFERASE; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; MYCOBACTERIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79851516691     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.099     Document Type: Article

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