-
1
-
-
0021813284
-
N-Acetylation pharmacogenetics
-
Weber W.W., and Hein D.W. N-Acetylation pharmacogenetics. Pharmacol. Rev. 37 (1985) 25-79
-
(1985)
Pharmacol. Rev.
, vol.37
, pp. 25-79
-
-
Weber, W.W.1
Hein, D.W.2
-
2
-
-
0031000414
-
Role of acetyltransferases in the metabolism and carcinogenicity of aromatic amines
-
King C.M., Land S.J., Jones R.F., Debiec-Rychter M., Lee M.S., and Wang C.Y. Role of acetyltransferases in the metabolism and carcinogenicity of aromatic amines. Mutat. Res. 376 (1997) 123-128
-
(1997)
Mutat. Res.
, vol.376
, pp. 123-128
-
-
King, C.M.1
Land, S.J.2
Jones, R.F.3
Debiec-Rychter, M.4
Lee, M.S.5
Wang, C.Y.6
-
3
-
-
0028040059
-
Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases
-
Hein D.W., Rustan T.D., Ferguson R.J., Doll M.A., and Gray K. Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. Arch. Toxicol. 68 (1994) 129-133
-
(1994)
Arch. Toxicol.
, vol.68
, pp. 129-133
-
-
Hein, D.W.1
Rustan, T.D.2
Ferguson, R.J.3
Doll, M.A.4
Gray, K.5
-
4
-
-
0026620225
-
Acetyltransferases and susceptibility to chemicals
-
Spec. Issue No. 123-30
-
Hein D.W., Rustan T.D., Doll M.A., Bucher K.D., Ferguson R.J., Feng Y., et al. Acetyltransferases and susceptibility to chemicals. Toxicol. Lett. (1992) 64-65 Spec. Issue No. 123-30
-
(1992)
Toxicol. Lett.
, pp. 64-65
-
-
Hein, D.W.1
Rustan, T.D.2
Doll, M.A.3
Bucher, K.D.4
Ferguson, R.J.5
Feng, Y.6
-
5
-
-
46249117928
-
On chemistry and function of coenzyme A
-
Lipmann F. On chemistry and function of coenzyme A. Bacteriol. Rev. 17 (1953) 1-16
-
(1953)
Bacteriol. Rev.
, vol.17
, pp. 1-16
-
-
Lipmann, F.1
-
6
-
-
0015239531
-
Acetyl-coenzyme A: arylamine N-acetyltransferase. Role of the acetyl-enzyme intermediate and the effects of substituents on the rate
-
Riddle B., and Jencks W.P. Acetyl-coenzyme A: arylamine N-acetyltransferase. Role of the acetyl-enzyme intermediate and the effects of substituents on the rate. J. Biol. Chem. 246 (1971) 3250-3258
-
(1971)
J. Biol. Chem.
, vol.246
, pp. 3250-3258
-
-
Riddle, B.1
Jencks, W.P.2
-
7
-
-
0026611267
-
Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms
-
Watanabe M., Sofuni T., and Nohmi T. Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms. J. Biol. Chem. 267 (1992) 8429-8436
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 8429-8436
-
-
Watanabe, M.1
Sofuni, T.2
Nohmi, T.3
-
8
-
-
0015523241
-
Acetyl coenzyme A: arylamine acetyltransferase. Measurement of the steady state concentration of the acetyl-enzyme intermediate
-
Jencks W.P., Gresser M., Valenzuela M.S., and Huneeus F.C. Acetyl coenzyme A: arylamine acetyltransferase. Measurement of the steady state concentration of the acetyl-enzyme intermediate. J. Biol. Chem. 247 (1972) 3756-3760
-
(1972)
J. Biol. Chem.
, vol.247
, pp. 3756-3760
-
-
Jencks, W.P.1
Gresser, M.2
Valenzuela, M.S.3
Huneeus, F.C.4
-
9
-
-
0034672467
-
Placental arylamine N-acetyltransferase type 1: potential contributory source of urinary folate catabolite p-acetamidobenzoylglutamate during pregnancy
-
Upton A., Smelt V., Mushtaq A., Aplin R., Johnson N., Mardon H., and Sim E. Placental arylamine N-acetyltransferase type 1: potential contributory source of urinary folate catabolite p-acetamidobenzoylglutamate during pregnancy. Biochim. Biophys. Acta 1524 (2000) 143-148
-
(2000)
Biochim. Biophys. Acta
, vol.1524
, pp. 143-148
-
-
Upton, A.1
Smelt, V.2
Mushtaq, A.3
Aplin, R.4
Johnson, N.5
Mardon, H.6
Sim, E.7
-
10
-
-
0028904406
-
Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells
-
Minchin R.F. Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochem. J. 307 (1995) 1-3
-
(1995)
Biochem. J.
, vol.307
, pp. 1-3
-
-
Minchin, R.F.1
-
11
-
-
0032829914
-
Lessons from the rifamycin biosynthetic gene cluster
-
Floss H.G., and Yu T.W. Lessons from the rifamycin biosynthetic gene cluster. Curr. Opin. Chem. Biol. 3 (1999) 592-597
-
(1999)
Curr. Opin. Chem. Biol.
, vol.3
, pp. 592-597
-
-
Floss, H.G.1
Yu, T.W.2
-
12
-
-
0033938882
-
Structure of arylamine N-acetyltransferase reveals a catalytic triad
-
Sinclair J.C., Sandy J., Delgoda R., Sim E., and Noble M.E. Structure of arylamine N-acetyltransferase reveals a catalytic triad. Nat. Struct. Biol. 7 (2000) 560-564
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 560-564
-
-
Sinclair, J.C.1
Sandy, J.2
Delgoda, R.3
Sim, E.4
Noble, M.E.5
-
13
-
-
23944518412
-
Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines
-
Sandy J., Mushtaq A., Holton S.J., Schartau P., Noble M.E., and Sim E. Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines. Biochem. J. 390 (2005) 115-123
-
(2005)
Biochem. J.
, vol.390
, pp. 115-123
-
-
Sandy, J.1
Mushtaq, A.2
Holton, S.J.3
Schartau, P.4
Noble, M.E.5
Sim, E.6
-
14
-
-
0036042103
-
The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis-an enzyme which inactivates the anti-tubercular drug, isoniazid
-
Sandy J., Mushtaq A., Kawamura A., Sinclair J., Sim E., and Noble M. The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis-an enzyme which inactivates the anti-tubercular drug, isoniazid. J. Mol. Biol. 318 (2002) 1071-1083
-
(2002)
J. Mol. Biol.
, vol.318
, pp. 1071-1083
-
-
Sandy, J.1
Mushtaq, A.2
Kawamura, A.3
Sinclair, J.4
Sim, E.5
Noble, M.6
-
15
-
-
33748094672
-
Structure and mechanism of arylamine N-acetyltransferases
-
Westwood I.M., Kawamura A., Fullam E., Russell A.J., Davies S.G., and Sim E. Structure and mechanism of arylamine N-acetyltransferases. Curr. Top. Med. Chem. 6 (2006) 1641-1654
-
(2006)
Curr. Top. Med. Chem.
, vol.6
, pp. 1641-1654
-
-
Westwood, I.M.1
Kawamura, A.2
Fullam, E.3
Russell, A.J.4
Davies, S.G.5
Sim, E.6
-
16
-
-
23944491300
-
Structure of Mesorhizobium loti arylamine N-acetyltransferase 1
-
Holton S.J., Dairou J., Sandy J., Rodrigues-Lima F., Dupret J.M., Noble M.E., and Sim E. Structure of Mesorhizobium loti arylamine N-acetyltransferase 1. Acta Crystallogr. Sect. F 61 (2005) 14-16
-
(2005)
Acta Crystallogr. Sect. F
, vol.61
, pp. 14-16
-
-
Holton, S.J.1
Dairou, J.2
Sandy, J.3
Rodrigues-Lima, F.4
Dupret, J.M.5
Noble, M.E.6
Sim, E.7
-
17
-
-
33748764946
-
NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity
-
Zhang N., Liu L., Liu F., Wagner C.R., Hanna P.E., and Walters K.J. NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity. J. Mol. Biol. 363 (2006) 188-200
-
(2006)
J. Mol. Biol.
, vol.363
, pp. 188-200
-
-
Zhang, N.1
Liu, L.2
Liu, F.3
Wagner, C.R.4
Hanna, P.E.5
Walters, K.J.6
-
18
-
-
36348936457
-
-
online manuscript
-
Wu H., Tempel W., Dombrovski L., Loppnau P., Weigelt J., Sundstrom M., et al. J. Biol. Chem. (2007) online manuscript
-
(2007)
J. Biol. Chem.
-
-
Wu, H.1
Tempel, W.2
Dombrovski, L.3
Loppnau, P.4
Weigelt, J.5
Sundstrom, M.6
-
20
-
-
14144256365
-
Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis
-
Sandy J., Holton S., Fullam E., Sim E., and Noble M. Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein Sci. 14 (2005) 775-782
-
(2005)
Protein Sci.
, vol.14
, pp. 775-782
-
-
Sandy, J.1
Holton, S.2
Fullam, E.3
Sim, E.4
Noble, M.5
-
21
-
-
34147171051
-
Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa
-
Westwood I.M., and Sim E. Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa. BMC Biochem. 8 (2007) 3
-
(2007)
BMC Biochem.
, vol.8
, pp. 3
-
-
Westwood, I.M.1
Sim, E.2
-
22
-
-
0034761725
-
Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism
-
Upton A.M., Mushtaq A., Victor T.C., Sampson S.L., Sandy J., Smith D.M., et al. Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Mol. Microbiol. 42 (2001) 309-317
-
(2001)
Mol. Microbiol.
, vol.42
, pp. 309-317
-
-
Upton, A.M.1
Mushtaq, A.2
Victor, T.C.3
Sampson, S.L.4
Sandy, J.5
Smith, D.M.6
-
23
-
-
26444539817
-
Genetic control of isoniazid acetylation in man
-
Evans D.A.P., Manley K.A., and McKuisick V.A. Genetic control of isoniazid acetylation in man. Br. Med. J. 2 (1960) 485-491
-
(1960)
Br. Med. J.
, vol.2
, pp. 485-491
-
-
Evans, D.A.P.1
Manley, K.A.2
McKuisick, V.A.3
-
24
-
-
2442466919
-
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target
-
Bhakta S., Besra G.S., Upton A.M., Parish T., Gibson K.J.C., Knutton S., et al. Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. J. Exp. Med. 199 (2004) 1-9
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1-9
-
-
Bhakta, S.1
Besra, G.S.2
Upton, A.M.3
Parish, T.4
Gibson, K.J.C.5
Knutton, S.6
-
25
-
-
0031943169
-
Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: mapping of their relationships to M. tuberculosis by fatty acid profile analysis, DNA-DNA hybridization, and 16S rRNA gene sequence analysis
-
Tonjum T., Welty D.B., Jantzen E., and Small P.L. Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: mapping of their relationships to M. tuberculosis by fatty acid profile analysis, DNA-DNA hybridization, and 16S rRNA gene sequence analysis. J. Clin. Microbiol. 36 (1998) 918-925
-
(1998)
J. Clin. Microbiol.
, vol.36
, pp. 918-925
-
-
Tonjum, T.1
Welty, D.B.2
Jantzen, E.3
Small, P.L.4
-
26
-
-
0032508046
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
-
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393 (1998) 537-544
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
-
27
-
-
0036774642
-
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv
-
Camus J.C., Pryor M.J., Medigue C., and Cole S.T. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Microbiology 148 (2002) 2967-2973
-
(2002)
Microbiology
, vol.148
, pp. 2967-2973
-
-
Camus, J.C.1
Pryor, M.J.2
Medigue, C.3
Cole, S.T.4
-
28
-
-
0032053328
-
Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium
-
Sinclair J.C., Delgoda R., Noble M.E., Jarmin S., Goh N.K., and Sim E. Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium. Protein Expression Purif. 12 (1998) 371-380
-
(1998)
Protein Expression Purif.
, vol.12
, pp. 371-380
-
-
Sinclair, J.C.1
Delgoda, R.2
Noble, M.E.3
Jarmin, S.4
Goh, N.K.5
Sim, E.6
-
29
-
-
0344089295
-
An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases
-
Brooke E.W., Davies S.G., Mulvaney A.W., Pompeo F., Sim E., and Vickers R.J. An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases. Bioorg. Med. Chem. 11 (2003) 1227-1234
-
(2003)
Bioorg. Med. Chem.
, vol.11
, pp. 1227-1234
-
-
Brooke, E.W.1
Davies, S.G.2
Mulvaney, A.W.3
Pompeo, F.4
Sim, E.5
Vickers, R.J.6
-
30
-
-
3042513718
-
Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies
-
Wang H., Vath G.M., Gleason K.J., Hanna P.E., and Wagner C.R. Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies. Biochemistry 43 (2004) 8234-8246
-
(2004)
Biochemistry
, vol.43
, pp. 8234-8246
-
-
Wang, H.1
Vath, G.M.2
Gleason, K.J.3
Hanna, P.E.4
Wagner, C.R.5
-
32
-
-
0036042103
-
The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis-an enzyme which inactivates the anti-tubercular drug, isoniazid
-
Sandy J., Mushtaq A., Kawamura A., Sinclair J., Sim E., and Noble M. The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis-an enzyme which inactivates the anti-tubercular drug, isoniazid. J. Mol. Biol. 318 (2002) 1071-1083
-
(2002)
J. Mol. Biol.
, vol.318
, pp. 1071-1083
-
-
Sandy, J.1
Mushtaq, A.2
Kawamura, A.3
Sinclair, J.4
Sim, E.5
Noble, M.6
-
34
-
-
0030444352
-
The diverse world of coenzyme A binding proteins
-
Engel C., and Wierenga R. The diverse world of coenzyme A binding proteins. Curr. Opin. Struct. Biol. 6 (1996) 790-797
-
(1996)
Curr. Opin. Struct. Biol.
, vol.6
, pp. 790-797
-
-
Engel, C.1
Wierenga, R.2
-
35
-
-
0021106279
-
Purification and physical-chemical properties of acetyl-CoA:arylamine N-acetyltransferase from pigeon liver
-
Andres H.H., Kolb H.J., and Weiss L. Purification and physical-chemical properties of acetyl-CoA:arylamine N-acetyltransferase from pigeon liver. Biochim. Biophys. Acta 746 (1983) 182-192
-
(1983)
Biochim. Biophys. Acta
, vol.746
, pp. 182-192
-
-
Andres, H.H.1
Kolb, H.J.2
Weiss, L.3
-
36
-
-
36348973779
-
-
Kawamura, A. (2005). Structural investigations of arylamine N-acetyltransferases from eukaryotes. PhD dissertation, University of Oxford.
-
-
-
-
37
-
-
34548063942
-
Functional characterization of single nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2
-
Zang Y., Doll M.A., Zhao S., States J.C., and Hein D.W. Functional characterization of single nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis 28 (2007) 1665-1671
-
(2007)
Carcinogenesis
, vol.28
, pp. 1665-1671
-
-
Zang, Y.1
Doll, M.A.2
Zhao, S.3
States, J.C.4
Hein, D.W.5
-
38
-
-
0035282779
-
Arylamine N-acetyltransferases-of mice, men and microorganisms
-
Upton A., Johnson N., Sandy J., and Sim E. Arylamine N-acetyltransferases-of mice, men and microorganisms. Trends Pharmacol. Sci. 22 (2001) 140-146
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, pp. 140-146
-
-
Upton, A.1
Johnson, N.2
Sandy, J.3
Sim, E.4
-
39
-
-
0022000324
-
New spectrophotometric and radiochemical assays for acetyl-CoA:arylamine N-acetyltransferase applicable to a variety of arylamines
-
Andres H.H., Klem A.J., Szabo S.M., and Weber W.W. New spectrophotometric and radiochemical assays for acetyl-CoA:arylamine N-acetyltransferase applicable to a variety of arylamines. Anal. Biochem. 145 (1985) 367-375
-
(1985)
Anal. Biochem.
, vol.145
, pp. 367-375
-
-
Andres, H.H.1
Klem, A.J.2
Szabo, S.M.3
Weber, W.W.4
-
40
-
-
0037023704
-
The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity
-
Mushtaq A., Payton M., and Sim E. The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity. J. Biol. Chem. 277 (2002) 12175-12181
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12175-12181
-
-
Mushtaq, A.1
Payton, M.2
Sim, E.3
-
41
-
-
0031060709
-
A fragment consisting of the first 204 amino-terminal amino acids of human arylamine N-acetyltransferase one (NAT1) and the first transacetylation step of catalysis
-
Sinclair J., and Sim E. A fragment consisting of the first 204 amino-terminal amino acids of human arylamine N-acetyltransferase one (NAT1) and the first transacetylation step of catalysis. Biochem. Pharmacol. 53 (1997) 11-16
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 11-16
-
-
Sinclair, J.1
Sim, E.2
-
43
-
-
0029927505
-
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
-
Shevchenko A., Wilm M., Vorm O., and Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68 (1996) 850-858
-
(1996)
Anal. Chem.
, vol.68
, pp. 850-858
-
-
Shevchenko, A.1
Wilm, M.2
Vorm, O.3
Mann, M.4
-
44
-
-
0028103275
-
The CCP4 Suite: programs for protein crystallography
-
Collaborative Computational Project
-
Collaborative Computational Project. The CCP4 Suite: programs for protein crystallography. Acta Crystallogr. Sect. D 50 (1994) 760-763
-
(1994)
Acta Crystallogr. Sect. D
, vol.50
, pp. 760-763
-
-
-
45
-
-
0035788107
-
Pushing the boundaries of molecular replacement with maximum likelihood
-
Read R.J. Pushing the boundaries of molecular replacement with maximum likelihood. Acta Crystallogr. Sect. D 57 (2001) 1373-1382
-
(2001)
Acta Crystallogr. Sect. D
, vol.57
, pp. 1373-1382
-
-
Read, R.J.1
-
46
-
-
13244281317
-
Coot: model-building tools for molecular graphics
-
Emsley P., and Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr. Sect. D 60 (2004) 2126-2132
-
(2004)
Acta Crystallogr. Sect. D
, vol.60
, pp. 2126-2132
-
-
Emsley, P.1
Cowtan, K.2
-
47
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov G.N., Vagin A.A., and Dodson E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. Sect. D 53 (1997) 240-255
-
(1997)
Acta Crystallogr. Sect. D
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
48
-
-
0032246470
-
Using MycDB on the World-Wide Web
-
Bergh S., and Cole S.T. Using MycDB on the World-Wide Web. Methods Mol. Biol. 101 (1998) 109-118
-
(1998)
Methods Mol. Biol.
, vol.101
, pp. 109-118
-
-
Bergh, S.1
Cole, S.T.2
|