The Bacillus anthracis arylamine N-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes

FEBS Letters

Volumn 585, Issue 24, 2011, Pages 3947-3952

  Pluvinage, Benjamin ^a,c   De La Sierra Gallay, Inés Li ^b,d   Kubiak, Xavier ^a   Xu, Ximing ^a   Dairou, Julien ^a   Dupret, Jean Marie ^a   Rodrigues Lima, Fernando ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

^c UNIVERSITY OF VICTORIA   (Canada)

^d UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Acetylation; Anthrax; Cofactor binding site; Loop; Xenobiotic metabolizing enzyme

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; BACTERIAL ENZYME; COENZYME A; SULFAMETHOXAZOLE;

ACETYLATION; ARTICLE; BACILLUS ANTHRACIS; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; BACILLUS ANTHRACIS; COENZYME A; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SULFAMETHOXAZOLE; XENOBIOTICS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); MAMMALIA; PROKARYOTA;

EID: 82555186986     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.10.041     Document Type: Article

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