Subchronic exposure to ethyl tertiary butyl ether resulting in genetic damage in Aldh2 knockout mice

Toxicology

Volumn 311, Issue 3, 2013, Pages 107-114

  Weng, Zuquan ^a   Suda, Megumi ^a   Ohtani, Katsumi ^a   Mei, Nan ^b   Kawamoto, Toshihiro ^c   Nakajima, Tamie ^d   Wang, Rui Sheng ^a  

^a NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Japan)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d CHUBU UNIVERSITY   (Japan)

Author keywords

Aldh2; Ethyl tertiary butyl ether; Genetic damage; Kinetics; Knockout mice

Indexed keywords

2 METHYL 1,2 PROPANEDIOL; 8 HYDROXYGUANINE; ACETALDEHYDE; BIOFUEL; DNA GLYCOSYLTRANSFERASE; ETHER DERIVATIVE; ETHYL TERTIARY BUTYL ETHER; PROPANEDIOL DERIVATIVE; TERT BUTYL ALCOHOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; EXPOSURE; FEMALE; GENOTOXICITY; GENOTYPE; HEREDITY; KNOCKOUT MOUSE; MALE; METABOLISM; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; WILD TYPE;

2-METHYL-1,2-PROPANEDIOL; 8-HYDROXYGUANINE DNA-GLYCOSYLASE; AA; ACETALDEHYDE; ALDEHYDE DEHYDROGENASE2; ALDH2; ETBE; ETHYL TERTIARY BUTYL ETHER; GENETIC DAMAGE; HOGG1; IARC; INTERNATIONAL AGENCY FOR RESEARCH ON CANCER; KINETICS; KNOCKOUT; KNOCKOUT MICE; KO; METHYL TERTIARY BUTYL ETHER; MICRONUCLEATED RETICULOCYTES; MICRONUCLEI IN THE MATURE NORMOCHROMATIC ERYTHROCYTE; MN-NCE; MN-RETS; MPD; MTBE; TBA; TERT-BUTYL ALCOHOL; WILD-TYPE; WT;

ACETALDEHYDE; ADMINISTRATION, INHALATION; ALDEHYDE DEHYDROGENASE; ANIMALS; COMET ASSAY; DNA DAMAGE; ETHYL ETHERS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRONUCLEUS TESTS; PROPYLENE GLYCOLS; SEX FACTORS; TERT-BUTYL ALCOHOL; TOXICITY TESTS, SUBCHRONIC;

EID: 84881240023     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.06.005     Document Type: Article

References (46)

1. Amberg A., Rosner E., Dekant W. Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humans. Toxicol. Sci. 1999, 51:1-8.
2. Baan R., Straif K., Grosse Y., Secretan B., El Ghissassi F., Bouvard V., Altieri A., Cogliano V. Carcinogenicity of alcoholic beverages. WHO International Agency for Research on Cancer Monograph Working Group. Lancet Oncol. 2007, 8:292-293.
3. Belpoggi F., Soffritti M., Maltoni C. Methyl-tertiary-butyl ether (MTBE) - a gasoline additive - causes testicular and lymphohaematopoietic cancers in rats. Toxicol. Ind. Health 1995, 11:119-149.
4. Borghoff S.J., Prescott J.S., Janszen D.B., Wong B.A., Everitt J.I. alpha 2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats. Toxicol. Sci. 2001, 61:176-186.
5. Brennan P., Lewis S., Hashibe M., Bell D.A., Boffetta P., Bouchardy C., Caporaso N., Chen C., Coutelle C., Diehl S.R., Hayes R.B., Olshan A.F., Schwartz S.M., Sturgis E.M., Wei Q., Zavras A.I., Benhamou S. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am. J. Epidemiol. 2004, 159:1-16.
6. Burleigh-Flayer H.D., Chun J.S., Kintigh W.J. Methy Terriary Buryl Ether: Vapor Inhalation Oncogenicity Study in CD-1 Mice. BRRC Report 91N0013A 1992, Union Carbide, Export, PA.
7. Chen Y.C., Peng G.S., Wang M.F., Tsao T.P., Yin S.J. Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. Chem. Biol. Interact. 2009, 178:2-7.
8. Collins A.R., Oscoz A.A., Brunborg G., Gaivão I., Giovannelli L., Kruszewski M., Smith C.C., Stetina R. The comet assay: topical issues. Mutagenesis 2008, 23:143-151.
9. Hagiwara A., Doi Y., Imai N., Nakashima H., Ono T., Kawabe M., Furukawa F., Tamano S., Nagano K., Fukushima S. Medium-term multi-organ carcinogenesis bioassay of ethyl tertiary-butyl ether in rats. Toxicology 2011, 289:160-166.
10. Hirayama K., Yasutake A., Inoue M. Effect of sex hormones on the fate of methylmercury and on glutathione metabolism in mice. Biochem Pharmacol 1987, 36:1919-1924.
11. Hong J.Y., Yang C.S., Lee M., Wang Y.Y., Huang W.Q., Tan Y., Patten C.J., Bondoc F.Y. Role of cytochromes P450 in the metabolism of methyl tert-butyl ether in human livers. Arch. Toxicol. 1997, 71:266-269.
12. International Agency for Research on Cancer, 2012. Agents Classified by IARC Monographs, 1-107.
13. Ishikawa H., Ishikawa T., Yamamoto H., Fukao A., Yokoyama K. Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. Mutat. Res. 2007, 615:134-142.
14. Isse T., Matsuno K., Oyama T., Kitagawa K., Kawamoto T. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Aging Clin. Exp. Res. 2005, 29:1959-1964.
15. Kim Y.D., Oyama T., Isse T., Kim H., Kawamoto T. Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study. Arch. Toxicol. 2005, 79:192-195.
16. Kitagawa K., Kawamoto T., Kunugita N., Tsukiyama T., Okamoto K., Yoshida A., Nakayama K., Nakayama K. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 2000, 476:306-311.
17. Kunugita N., Isse T., Oyama T., Kitagawa K., Ogawa M., Yamaguchi T., Kinaga T., Kawamoto T. Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde. J. Toxicol. Sci. 2008, 33:31-36.
18. Lindamood C., Farnell D.R., Giles H.D., Prejean J.D., Collins J.J., Takahashi K., Maronpot R.R. Subchronic toxicity studies of t-butyl alcohol in rats and mice. Fundam. Appl. Toxicol. 1992, 19:91-100.
19. Martelli A., Mattioli F., Angiola M., Reimann R., Brambilla G. Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes. Mutat. Res. 2003, 536:69-78.
20. Matsuda T., Yabushita H., Kanaly R.A., Shibutani S., Yokoyama A. Increased DNA damage in ALDH2-deficient alcoholics. Chem. Res. Toxicol. 2006, 19:1374-1378.
21. Matsuo K., Hamajima N., Shinoda M., Hatooka S., Inoue M., Takezaki T., Tajima K. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. Carcinogenesis 2001, 22:913-916.
22. McGregor D. Ethyl tertiary-butyl ether: a toxicological review. Crit. Rev. Toxicol. 2007, 37:287-312.
23. Medinsky M.A., Wolf D.C., Cattley R.C., Wong B., Janszen D.B., Farris G.M., Wright G.A., Bond J.A. Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on fischer-344 rats and CD-1 mice. Toxicol. Sci. 1999, 51:108-118.
24. Morimoto K., Takeshita T. Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. Environ. Health Perspect. 1996, 104(Suppl. 3):563-567.
25. Moriya M., Grollman A.P. Mutations in the mutY gene of Escherichia coli enhance the frequency of targeted G:C-->T:A transversions induced by a single 8-oxoguanine residue in single-stranded DNA. Mol. Gen. Genet. 1993, 239:72-76.
26. Nagayoshi H., Matsumoto A., Nishi R., Kawamoto T., Ichiba M., Matsuda T. Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol. Mutat. Res. 2009, 673:74-77.
27. Ogawa M., Isse T., Oyama T., Kunugita N., Yamaguchi T., Kinaga T., Narai R., Matsumoto A., Kim Y.D., Kim H., Uchiyama I., Kawamoto T. Urinary 8-hydoxydeoxyguanosine (8-OHdG) and plasma malondialdehyde (MDA) levels in Aldh2 knock-out mice under acetaldehyde exposure. Ind. Health 2006, 44:179-183.
28. Rashkovetsky L.G., Maret W., Klyosov A.A. Human liver aldehyde dehydrogenases: new method of purification of the major mitochondrial and cytosolic enzymes and re-evaluation of their kinetic properties. Biochim. Biophys. Acta 1994, 1205:301-307.
29. Saito A., Sasaki T., Kasai T., Katagiri T., Nishizawa T., Noguchi T., Aiso S., Nagano K., Fukushima S. Hepatotumorigenicity of ethyl tertiary-butyl ether with 2-year inhalation exposure in F344 rats. Arch. Toxicol. 2013, 87905-87914.
30. Seitz H.K., Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat. Rev. Cancer 2007, 7:599-612.
31. Sgambato A., Iavicoli I., De Paola B., Bianchino G., Boninsegna A., Bergamaschi A., Pietroiusti A., Cittadini A. Differential toxic effects of methyl tertiary butyl ether and tert-butanol on rat fibroblasts in vitro. Toxicol. Ind. Health 2009, 25:141-151.
32. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
33. Smith C.C., O'Donovan M.R., Martin E.A. hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. Mutagenesis 2006, 21:185-190.
34. Suzuki M., Yamazaki K., Kano H., Aiso S., Nagano K., Fukushima S. No carcinogenicity of ethyl tertiary-butyl ether by 2-year oral administration in rats. J. Toxicol. Sci. 2012, 37:1239-1246.
35. Takahashi K., Lindamood C., Maronpot R.R. Retrospective study of possible alpha-2 mu-globulin nephropathy and associated cell proliferation in male Fischer 344 rats dosed with t-butyl alcohol. Environ. Health Perspect. 1993, 101(Suppl 5):281-285.
36. Takeshita T., Kawai T., Morimoto K. Elevated levels of hemoglobin-associated acetaldehyde related to alcohol drinking in the atypical genotype of low Km aldehyde dehydrogenase. Cancer Res. 1997, 57:1241-1243.
37. Turini A., Amato G., Longo V., Gervasi P.G. Oxidation of methyl- and ethyl- tertiary-butyl ethers in rat liver microsomes: role of the cytochrome P450 isoforms. Arch. Toxicol. 1998, 72:207-214.
38. Weng Z., Weng H., Lu Y., Nakayama K., Morimoto K. Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. Mutat. Res. 2010, 701:132-136.
39. Weng Z., Suda M., Ohtani K., Mei N., Kawamoto T., Nakajima T., Wang R.S. Aldh2 Knockout Mice Were More Sensitive to DNA Damage in Leukocyte due to Ethyl Tertiary Butyl Ether Exposure. Ind. Health 2011, 49:396-399.
40. Weng Z., Suda M., Ohtani K., Mei N., Kawamoto T., Nakajima T., Wang R.S. Differential genotoxic effects of subchronic exposure to ethyl tertiary butyl ether in the livers of Aldh2 knockout and wild-type mice. Arch. Toxicol. 2012, 86:675-682.
41. Yokoyama A., Mizukami T., Omori T., Yokoyama T., Hirota T., Matsushita S., Higuchi S., Maruyama K., Ishii H., Hibi T. Melanosis and squamous cell neoplasms of the upper aerodigestive tract in Japanese alcoholic men. Cancer Sci. 2006, 97:905-911.
42. Yokoyama A., Muramatsu T., Ohmori T., Yokoyama T., Okuyama K., Takahashi H., Hasegawa Y., Higuchi S., Maruyama K., Shirakura K., Ishii H. Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 1998, 19:1383-1387.
43. Yokoyama A., Watanabe H., Fukuda H., Haneda T., Kato H., Yokoyama T., Muramatsu T., Igaki H., Tachimori Y. Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers. Cancer Epidemiol. Biomarkers Prev. 2002, 11:895-900.
44. Yuan Y., Wang H.F., Sun H.F., Du H.F., Xu L.H., Liu Y.F., Ding X.F., Fu D.P., Liu K.X. Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry. Environ. Toxicol. 2007, 22:630-635.
45. Zorzano A., Herrera E. Differences in the kinetic properties and sensitivity to inhibitors of human placental, erythrocyte, and major hepatic aldehyde dehydrogenase isoenzymes. Biochem. Pharmacol. 1990, 39:873-878.
46. van Wezel A., Puijker L., Vink C., Versteegh A., de Voogt P. Odour and flavour thresholds of gasoline additives (MTBE, ETBE and TAME) and their occurrence in Dutch drinking water collection areas. Chemosphere 2009, 76:672-676.