Elevated levels of hemoglobin-associated acetaldehyde related to alcohol drinking in the atypical genotype of low K(m) aldehyde dehydrogenase

Cancer Research

Volumn 57, Issue 7, 1997, Pages 1241-1243

  Takeshita, Tatsuya ^a   Kawai, Toshio ^b   Morimoto, Kanehisa ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b Osaka Occupational Health Service Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; HEMOGLOBIN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CLINICAL ARTICLE; CYTOTOXICITY; DETOXIFICATION; DRINKING BEHAVIOR; EXON; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH RISK POPULATION; HUMAN; HYPERSENSITIVITY; LIVER CARCINOGENESIS; MALE; PRIORITY JOURNAL;

ACETALDEHYDE; ADOLESCENT; ADULT; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; GENOTYPE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; TIME FACTORS;

EID: 0030984282     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. IARC. Alcohol Drinking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 44. Lyon, France: IARC, 1988.
2. Yokoyama, A., Muramatsu, T., Ohmori, T., Higuchi, S., Hayashida, M., and Ishii, H. Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol., Biomarkers & Prev., 5: 99-102, 1996.
3. m aldehyde dehydrogenase in Japanese workers. Lancet, 341: 837-838, 1993.
4. m aldehyde dehydrogenase in a Japanese population. Hum. Genet., 94: 217-223, 1994.
5. Goedde, H. W., Harada, S., and Agarwal, D. P. Racial differences in alcohol sensitivity: a new hypothesis. Hum. Genet., 51: 331-334, 1979.
6. Harada, S., Agarwal, D. P., and Goedde, H. W. Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet, ii; 982, 1981.
7. Enomoto, N., Takase, S., Yasuhara, M., and Takada, A. Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol. Clin. Exp. Res., 15: 141-144, 1991.
8. Hsu, L. C., Tani, K., Fujiyoshi, T., Kurachi, K., and Yoshida, A. Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. Proc. Natl. Acad. Sci. USA, 82: 3771-3775, 1985.
9. Wickramasinghe, S. N., Gardner, B., and Barden, G. Cytotoxic protein molecules generated as a consequence of ethanol metabolism in vitro and in vivo. Lancet, 2: 823-826, 1986.
10. 32P-postlabelling method for the analysis of adducts arising through the reaction of acetaldehyde with 2′-deoxyguanosine-3′-monophosphate and DNA. Carcinogenesis (Lond.), 16: 2177-2185, 1995.
11. Woutersen, R. A., Appelman, L. M., Van, G. H. A., and Feron, V. J. Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study. Toxicology, 41: 213-231, 1986.
12. Peterson, C. M., and Polizzi, C. M. Improved method for acetaldehyde in plasma and hemoglobin-associated acetaldehyde: results in teetotalers and alcoholics reporting for treatment. Alcohol, 4: 477-480, 1987.
13. Mizoi, Y., Kogame, M., Fukunaga, T., Ueno, Y., Adachi, J., and Fujiwara, S. Polymorphism of aldehyde dehydrogenase and ethanol elimination. Alcohol, 2: 393-396, 1985.
14. Sorrel, M. F., and Tuma, D. J. The functional implications of acetaldehyde binding to cell constituents. Ann. NY Acad. Sci., 492: 50-62, 1987.
15. Peterson, C. M., Jovanovic-Peterson, L., and Schmid-Formby, F. Rapid association of acetaldehyde with hemoglobin in human volunteers after low-dose ethanol. Alcohol, 5: 371-374, 1988.
16. Yin, S. J., Chou, R J., Chao, S. F., Tsai, S. F., Liao, C. S., Wang, S. L., Wu, C. W., and Lee, S. C. Alcohol and aldehyde dehydrogenases in human esophagus: comparison with the stomach enzyme activities. Alcohol. Clin. Exp. Res., 17: 376-381, 1993.
17. Baraona, E., Padova, C. D., Tabasco, J., and Lieber, C. S. Red blood cells: a new major modality for acetaldehyde transport from liver to other tissues. Life Sci., 40: 253-258, 1987.
18. m aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. Environ. Health Perspect., 104(SuppL 3): 563-567, 1996.
19. Nakajima, M., Takeuchi, T., Takeshita, T., and Morimoto, K. 8-Hydroxydeoxy-guanosine in human leukocyte DNA and daily health practice factors: effects of individual alcohol sensitivity. Environ, Health Perspect., 104: 1336-1338, 1996.
20. Garro, A. J., and Lieber, C. S. Alcohol and cancer. Annu. Rev. Pharmacol. Toxicol., 30: 219-249, 1990.