Hepatotumorigenicity of ethyl tertiary-butyl ether with 2-year inhalation exposure in F344 rats

Archives of Toxicology

Volumn 87, Issue 5, 2013, Pages 905-914

  Saito, Arata ^a   Sasaki, Toshiaki ^a   Kasai, Tatuya ^a   Katagiri, Taku ^a   Nishizawa, Tomoshi ^a   Noguchi, Tadashi ^a   Aiso, Shigetoshi ^a   Nagano, Kasuke ^b   Fukushima, Shoji ^a  

^a JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

^b Nagano Toxicologic Pathology Consulting   (Japan)

Author keywords

ETBE; Ethyl tertiary butyl ether; Hepatotumorigenicity; Inhalation; Kidney; Rat

Indexed keywords

ALBUMIN; ASPARTATE AMINOTRANSFERASE; CALCIUM; CHLORINE; CREATININE; ETHER DERIVATIVE; ETHYL TERT BUTYL ETHER; GAMMA GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; NITROGEN; PHOSPHATE; PHOSPHOLIPID; POTASSIUM; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CARCINOGEN; ETHYL TERT-BUTYL ETHER;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BASOPHIL; BODY WEIGHT; CALCIUM BLOOD LEVEL; CAUSE OF DEATH; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; EOSINOPHIL; EXPOSURE; FEMALE; FISCHER 344 RAT; GOOD LABORATORY PRACTICE; HEALTH HAZARD; HISTOPATHOLOGY; HYPERPLASIA; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; KIDNEY MASS; KIDNEY PAPILLA; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; PELVIS; PHOSPHATE BLOOD LEVEL; PHOSPHOLIPID BLOOD LEVEL; POTASSIUM BLOOD LEVEL; PRACTICE GUIDELINE; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SUBCUTANEOUS TISSUE TUMOR; SURVIVAL RATE; TRIACYLGLYCEROL BLOOD LEVEL; UROTHELIAL HYPERPLASIA; ADENOMA; AIR POLLUTANT; ANIMAL; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; CHRONIC DISEASE; DRUG EFFECT; KIDNEY; KIDNEY DISEASE; LIVER TUMOR; PATHOLOGY;

RATTUS;

ADENOMA; AIR POLLUTANTS; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CHRONIC DISEASE; ETHYL ETHERS; FEMALE; INHALATION EXPOSURE; KIDNEY; KIDNEY DISEASES; LIVER NEOPLASMS; MALE; RATS; RATS, INBRED F344; SEX FACTORS;

EID: 84886929088     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0997-x     Document Type: Article

References (21)

1. Ahmed FE (2001) Toxicology and human health effects following exposure to oxygenated or reformulated gasoline. Toxicol Lett 123:89-113
2. Alden CL, Frith CH (1991) Urinary system. In: Haschek WM, Rousseaux CG (eds) Handbook of toxicologic pathology academic press. San Diego, CA, pp 315-387
3. Barthold SW (1979) Chronic progressive nephropathy in aging rats. Toxicol Pathol 7:1-6
4. Bird MG, Burleigh-Flayer HD, Chun JS, Douglas JF, Kneiss JJ, Andrews LS (1997) Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. J Appl Toxicol 17(Suppl 1):S45-S55
5. Eitaki Y, Kawai T, Omae K (2011) Exposure assessment of ETBE in gas station workers and gasoline tanker truck drivers. J Occp Health 53:423-431
6. Gary AB, Scot LE, Michael RE, Charles AM, William FM (1990) Liver In: Pathology of the Fischer Rat. Academic Press, San Diego, pp 71-94
7. Hagiwara A, Doi Y, Imai N, Nakashima H, Ono T, Kawabe M, Furukawa F, Tamano S, Nagano K, Fukushima S (2011) Medium-Term multi-organ carcinogenesis bioassay of ethyl tertiary-butyl ether in rats. Toxicology 289:160-166
8. Hard GC, Khan KN (2004) A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol Pathol 32:171-180
9. Japan Petroleum Energy Center (JPEC) (2008) ETBE Risk Assessment Report. 1-108. In: Report on research in promotion of the use of nonfossil fuel (biomass in origin) introduction (PEC-2007L-06) (English). http://www.pecj.or.jp/ english/news/pdf/b-2-8.pdf Accessed 5 July 2012
10. Kawai K (1980) Report from the working group on long-Term holding of experimental animals. Exp Animals 29:181-231 (in Japanese)
11. Maltoni C, Belpoggi F, Soffritti M, Minardi F (1999) Comprehensive long-Term experimental project of carcinogenicity bioassays on gasoline oxygenated additives: plan and first report of results from the study on ethyl-Tertiary-butyl ether (ETBE). Eur J Oncol 4:493-508
12. Mauderly JL, Tesarek JE, Sifford LJ, Sifford LJ (1979) Respiratory measurements of unsedated small laboratory mammals using nonrebreathing valves. Lab Anim Sci 29:323-329
13. McGregor D (2006) Methyl tertiary-butyl ether: studies for potential human health hazards. Crit Rev Toxicol 36:319-358
14. McGregor D (2007) Ethyl tertiary-butyl ether: a toxicological review. Crit Rev Toxicol 37:287-312
15. Medinsky MA, Wolf DC, Cattley RC, Wong B, Janszen DB, Farris GM, Wright GA, Bond JA (1999) Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on Fischer-344 rats and CD-1 mice. Toxicol Sci 51:108-118
16. National Research Council (NRC) (1996) Guide for the care and use of laboratory animals. Institute of Laboratory Animal Resources commission on Life Sciences. NRC. National Academies Press, Washington, DC
17. Organization for economic co-operation and development (OECD) (1981) OECD guideline for testing of chemicals 451 for ''Carcinogenicity studies'' Adopted 12 May 1981. OECD, Paris
18. Organization for Economic Co-operation and Development (OECD) (1998) OECD series on principles of good laboratory practice. Series on principles of good laboratory practice and compliance monitoring No.1. ENV/MC/CHEM (98), Vol 17. OECD, Paris
19. Peto R, Pike MC, Day NE, Gray RG, Lee PN, Parish S, Peto J, Richards S, Wahrendorf J (1980) Guidelines for simple, sensitive significance tests for carcinogenic effects in long-Term animal experiments. In Long-Term and short-Term screening assays for carcinogens: a critical appraisal. IARC Monographs, Suppl 2, IARC, Lyon, France, pp 311-426
20. Seely JC, Hard GC (2008) Chronic progressive nephropathy (CPN) in the rat: review of pathology and relationship to renal tumorigenesis. J Toxicol Pathol 21:199-205
21. U.S. Environmental Protection Agency (U.S. EPA) (1991) Alpha-2uglobulin: association with chemically induced renal toxicity and neoplasia in the male rat. Risk Assessment Forum. U.S. Environmental Protection Agency, Washington, DC. EPA/625/3-91/019F