Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: A pilot study

Archives of Toxicology

Volumn 79, Issue 4, 2005, Pages 192-195

  Kim, Yong Dae ^a   Oyama, Tsunehiro ^b   Isse, Toyohi ^b   Kim, Heon ^a   Kawamoto, Toshihiro ^b  

^a Chungbuk National University College of Medicine   (South Korea)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Aldh2 deficient mice; CYP; Ethanol; Immunoblotting; Liver

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2E1; CYTOCHROME P450 4B1;

ALCOHOL METABOLISM; ALCOHOL OXIDATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EXPOSURE; IMMUNOBLOTTING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; WILD TYPE;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ETHANOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; IMMUNOBLOTTING; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES, LIVER; PILOT PROJECTS;

EID: 18044396719     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0630-8     Document Type: Article

References (17)

1. Agarwal DP, Goedde HW (1992) Pharmacogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 2:48-62
2. Blum HE (2001) Hepatocellular carcinoma: susceptibility markers. IARC Sci Publ 154:241-244
3. Boonyaphiphat P, Thongsuksai P, Sriplung H, Puttawibul P (2002) Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett 186:193-199
4. Chao YC, Wang LS, Hsieh TY, Chu CW, Chang FY, Chu HC (2000) Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. Am J Gastroenterol 95:2958-2964
5. Imaoka S, Yoneda Y, Sugimoto T, Hiroi T, Yamamoto K, Nakatani T, Funae Y (2000) CYP4B1 is a possible risk factor for bladder cancer in humans. Biochem Biophys Res Commun 277:776-780
6. Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, Nakayama K, Nakayama K, Kawamoto T (2002) Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12:621-626
7. Itoga S, Nomura F, Makino Y, Tomonaga T, Shimada H, Ochiai T, Iizasa T, Baba M, Fujisawa T, Harada S (2002) Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer. Alcohol Clin Exp Res 26:15S-19S
8. Katoh T, Kaneko S, Kohshi K, Munaka M, Kitagawa K, Kunugita N, Ikemura K, Kawamoto T (1999) Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. Int J Cancer 26:606-609
9. Kitagawa K, Kawamoto T, Kunugita N, Tsukiyama T, Okamoto K, Yoshida A, Nakayama K, Nakayama K (2000) Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 476:306-311
10. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
11. Lieber CS (1999) Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998) - a review. Alcohol Clin Exp Res 23:991-1007
12. McLemore TL, Adelberg SMC, McMahon NA, Yu SJ, Hubbard WC, Czerwinski M, Wood TG, Storeng R, Lubet RA (1990) Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. J Natl Cancer Inst 82:1333-1339
13. Novak RF, Woodcroft KJ (2000) The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression. Arch Pharm Res 23:267-282
14. Roberts BJ, Song, BJ, Soh Y, Park SS, Shoaf SE (1995) Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. J Biol Chem 270:29632-29635
15. Schoedel KA, Sellers EM, Tyndale RF (2001) Induction of CYP2B1 and nicotine metabolism by ethanol in rat liver but not rat brain. Biochem Pharmacol 62:1025-1036
16. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. P Natl Acad Sci USA 76:4350-4354
17. Yin SJ (1994) Alcohol dehydrogenase: enzymology and metabolism. Alcohol Alcoholism Suppl 2:113-119