Aldh2 knockout mice were more sensitive to DNA damage in leukocytes due to ethyl tertiary butyl ether exposure

Industrial Health

Volumn 49, Issue 3, 2011, Pages 396-399

  Weng, Zuquan ^a   Suda, Megumi ^a   Ohtani, Katsumi ^a   Mei, Nan ^b   Kawamoto, Toshihiro ^c   Nakajima, Tamie ^d   Wang, Rui Sheng ^a  

^a NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Japan)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

Author keywords

Acetaldehyde; Aldehyde dehydrogenase; Aldh2 knockout mice; Comet assay; Ethyl tertiary butyl ether; Genotoxicity; Leukocyte

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; ETHER DERIVATIVE; ETHYL TERT BUTYL ETHER; ETHYL TERT-BUTYL ETHER;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; DISEASE MODEL; DNA DAMAGE; EXPOSURE; FEMALE; GENETICS; LEUKOCYTE; MALE; MOUSE; MOUSE MUTANT; SEX DIFFERENCE; STATISTICS;

ALDEHYDE DEHYDROGENASE; ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; DNA DAMAGE; ETHYL ETHERS; FEMALE; INHALATION EXPOSURE; LEUKOCYTES; MALE; MICE; MICE, KNOCKOUT; SEX FACTORS; STATISTICS AS TOPIC;

MUS;

EID: 79959317614     PISSN: 00198366     EISSN: None     Source Type: Journal    
DOI: 10.2486/indhealth.MS1188     Document Type: Article

References (22)

1. Stern BR, Kneiss JJ (1997) Methyl tertiary-butyl ether (MTBE): use as an oxygenate in fuels. J Appl Toxicol 17(Suppl 1), S1-2.
2. McGregor D (2007) Ethyl tertiary-butyl ether: a toxicological review. Crit Rev Toxicol 37, 287-312.
3. Amberg A, Rosner E, Dekant W (2000) Biotransformation and kinetics of excretion of ethyl tert-butyl ether in rats and humans. Toxicol Sci 53, 194-201.
4. Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Altieri A, Cogliano V (2007) Carcinogenicity of alcoholic beverages. WHO International Agency for Research on Cancer Monograph Working Group. Lancet Oncol 8, 292-3.
5. Chen YC, Peng GS, Wang MF, Tsao TP, Yin SJ (2009) Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. Chem Biol Interact 178, 2-7.
6. Wang RS, Nakajima T, Kawamoto T, Honma T (2002) Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. Drug Metab Dispos 30, 69-73.
7. Kitagawa K, Kawamoto T, Kunugita N, Tsukiyama T, Okamoto K, Yoshida A, Nakayama K, Nakayama K (2000) Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 476, 306-11.
8. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175, 184-91.
9. Collins AR, Oscoz AA, Brunborg G, Gaivão I, Giovannelli L, Kruszewski M, Smith CC, Stetina R (2008) The comet assay: topical issues. Mutagenesis 23, 143-51.
10. Medinsky MA, Wolf DC, Cattley RC, Wong B, Janszen DB, Farris GM, Wright GA, Bond JA (1999) Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on fischer-344 rats and CD-1 mice. Toxicol Sci 51, 108-18.
11. Isse T, Matsuno K, Oyama T, Kitagawa K, Kawamoto T (2005) Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin Exp Res 29, 1959-64.
12. Woutersen RA, Appelman LM, Van Garderen-Hoetmer A, Feron VJ (1986) Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study. Toxicology 41, 213-31.
13. Feron VJ, Kruysse A, Woutersen RA (1982) Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine. Eur J Cancer Clin Oncol 18, 13-31.
14. Singh NP, Khan A (1995) Acetaldehyde: genotoxicity and cytotoxicity in human lymphocytes. Mutat Res 337, 9-17.
15. Lamarche F, Gonthier B, Signorini N, Eysseric H, Barret L (2004) Impact of ethanol and acetaldehyde on DNA and cell viability of cultured neurones. Cell Biol Toxicol 20, 361-74.
16. Ishikawa H, Ishikawa T, Yamamoto H, Fukao A, Yokoyama K (2007) Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. Mutat Res 615, 134-42.
17. Ishikawa H, Miyatsu Y, Kurihara K, Yokoyama K (2006) Gene-environmental interactions between alcoholdrinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes. Mutat Res 594, 1-9.
18. Takeshita T, Kawai T, Morimoto K (1997) Elevated levels of hemoglobin-associated acetaldehyde related to alcohol drinking in the atypical genotype of low Km aldehyde dehydrogenase. Cancer Res 57, 1241-3.
19. Yuan Y, Wang HF, Sun HF, Du HF, Xu LH, Liu YF, Ding XF, Fu DP, Liu KX (2007) Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry. Environ Toxicol 22, 630-5.
20. Sgambato A, Iavicoli I, De Paola B, Bianchino G, Boninsegna A, Bergamaschi A, Pietroiusti A, Cittadini A (2009) Differential toxic effects of methyl tertiary butyl ether and tert-butanol on rat fibroblasts in vitro. Toxicol Ind Health 25, 141-51.
21. Lindamood C 3rd, Farnell DR, Giles HD, Prejean JD, Collins JJ, Takahashi K, Maronpot RR (1992) Subchronic toxicity studies of t-butyl alcohol in rats and mice. Fundam Appl Toxicol 19, 91-100.
22. Borghoff SJ, Prescott JS, Janszen DB, Wong BA, Everitt JI (2001) alpha 2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats. Toxicol Sci 61, 176-86.