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Volumn 110, Issue 31, 2013, Pages 12661-12666

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROLINE RICH AKT SUBSTRATE OF 40 KDA; PROLINE RICH PROTEIN; UNCLASSIFIED DRUG;

EID: 84881097036     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1301455110     Document Type: Article
Times cited : (89)

References (36)
  • 1
    • 3042608187 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
    • McMullen JR, et al. (2004) Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 109(24): 3050-3055.
    • (2004) Circulation , vol.109 , Issue.24 , pp. 3050-3055
    • McMullen, J.R.1
  • 2
    • 71649084135 scopus 로고    scopus 로고
    • Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction
    • Buss SJ, et al. (2009) Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J Am Coll Cardiol 54(25): 2435-2446.
    • (2009) J Am Coll Cardiol , vol.54 , Issue.25 , pp. 2435-2446
    • Buss, S.J.1
  • 3
    • 79952235006 scopus 로고    scopus 로고
    • Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation
    • Marin TM, et al. (2011) Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. J Clin Invest 121(3):1026-1043.
    • (2011) J Clin Invest , vol.121 , Issue.3 , pp. 1026-1043
    • Marin, T.M.1
  • 4
    • 67949092694 scopus 로고    scopus 로고
    • Reducing the risk of left ventricular hypertrophy in kidney transplant recipients: The potential role of mammalian target of rapamycin
    • Paoletti E, Cannella G (2009) Reducing the risk of left ventricular hypertrophy in kidney transplant recipients: The potential role of mammalian target of rapamycin. Transplant Proc 41(6, Suppl):S3-S5.
    • (2009) Transplant Proc , vol.41 , Issue.6 SUPPL.
    • Paoletti, E.1    Cannella, G.2
  • 5
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149(2):274-293.
    • (2012) Cell , vol.149 , Issue.2 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 6
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12(1):21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , Issue.1 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 7
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40(2):310-322.
    • (2010) Mol Cell , vol.40 , Issue.2 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 8
    • 33947264077 scopus 로고    scopus 로고
    • PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
    • Sancak Y, et al. (2007) PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25(6):903-915.
    • (2007) Mol Cell , vol.25 , Issue.6 , pp. 903-915
    • Sancak, Y.1
  • 10
    • 34548359244 scopus 로고    scopus 로고
    • PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
    • Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (2007) PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem 282(34):24514-24524.
    • (2007) J Biol Chem , vol.282 , Issue.34 , pp. 24514-24524
    • Fonseca, B.D.1    Smith, E.M.2    Lee, V.H.3    MacKintosh, C.4    Proud, C.G.5
  • 11
    • 34547133519 scopus 로고    scopus 로고
    • The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
    • Oshiro N, et al. (2007) The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem 282(28): 20329-20339.
    • (2007) J Biol Chem , vol.282 , Issue.28 , pp. 20329-20339
    • Oshiro, N.1
  • 12
    • 34547099855 scopus 로고    scopus 로고
    • PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    • Wang L, Harris TE, Roth RA, Lawrence JCJ, Jr. (2007) PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282(27): 20036-20044.
    • (2007) J Biol Chem , vol.282 , Issue.27 , pp. 20036-20044
    • Wang, L.1    Harris, T.E.2    Roth, R.A.3    Lawrence Jr., J.C.J.4
  • 14
    • 0037855834 scopus 로고    scopus 로고
    • Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
    • Kovacina KS, et al. (2003) Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem 278(12):10189-10194.
    • (2003) J Biol Chem , vol.278 , Issue.12 , pp. 10189-10194
    • Kovacina, K.S.1
  • 15
    • 4344574540 scopus 로고    scopus 로고
    • Large-scale characterization of HeLa cell nuclear phosphoproteins
    • Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci USA 101(33):12130-12135.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.33 , pp. 12130-12135
    • Beausoleil, S.A.1
  • 16
    • 33845513785 scopus 로고    scopus 로고
    • Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats
    • Nascimento EB, et al. (2006) Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Diabetes 55(12):3221-3228.
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3221-3228
    • Nascimento, E.B.1
  • 17
    • 41649101570 scopus 로고    scopus 로고
    • The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK
    • Fonseca BD, Lee VH-Y, Proud CG (2008) The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. Biochem J 411(1):141-149.
    • (2008) Biochem J , vol.411 , Issue.1 , pp. 141-149
    • Fonseca, B.D.1    Lee, V.H.-Y.2    Proud, C.G.3
  • 18
    • 0142027759 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
    • McMullen JR, et al. (2003) Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA 100(21):12355-12360.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.21 , pp. 12355-12360
    • McMullen, J.R.1
  • 19
    • 78650121847 scopus 로고    scopus 로고
    • Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies
    • Bernardo BC, Weeks KL, Pretorius L, McMullen JR (2010) Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies. Pharmacol Ther 128(1):191-227.
    • (2010) Pharmacol Ther , vol.128 , Issue.1 , pp. 191-227
    • Bernardo, B.C.1    Weeks, K.L.2    Pretorius, L.3    McMullen, J.R.4
  • 20
    • 1842579393 scopus 로고    scopus 로고
    • Hypertrophy of the heart: A new therapeutic target?
    • Frey N, Katus HA, Olson EN, Hill JA (2004) Hypertrophy of the heart: A new therapeutic target? Circulation 109(13):1580-1589.
    • (2004) Circulation , vol.109 , Issue.13 , pp. 1580-1589
    • Frey, N.1    Katus, H.A.2    Olson, E.N.3    Hill, J.A.4
  • 21
    • 0036143851 scopus 로고    scopus 로고
    • Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress
    • Esposito G, et al. (2002) Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105(1):85-92.
    • (2002) Circulation , vol.105 , Issue.1 , pp. 85-92
    • Esposito, G.1
  • 22
    • 34547665415 scopus 로고    scopus 로고
    • Small-molecule therapies for cardiac hypertrophy: Moving beneath the cell surface
    • McKinsey TA, Kass DA (2007) Small-molecule therapies for cardiac hypertrophy: Moving beneath the cell surface. Nat Rev Drug Discov 6(8):617-635.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.8 , pp. 617-635
    • McKinsey, T.A.1    Kass, D.A.2
  • 23
    • 80051968584 scopus 로고    scopus 로고
    • In search of new therapeutic targets and strategies for heart failure: Recent advances in basic science
    • Shah AM, Mann DL (2011) In search of new therapeutic targets and strategies for heart failure: Recent advances in basic science. Lancet 378(9792):704-712.
    • (2011) Lancet , vol.378 , Issue.9792 , pp. 704-712
    • Shah, A.M.1    Mann, D.L.2
  • 24
    • 80052399996 scopus 로고    scopus 로고
    • AAV vectors for cardiac gene transfer: Experimental tools and clinical opportunities
    • Pacak CA, Byrne BJ (2011) AAV vectors for cardiac gene transfer: Experimental tools and clinical opportunities. Mol Ther 19(9):1582-1590.
    • (2011) Mol Ther , vol.19 , Issue.9 , pp. 1582-1590
    • Pacak, C.A.1    Byrne, B.J.2
  • 25
    • 62649133817 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a firstin-human phase 1/2 clinical trial
    • Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID) Trial Investigators
    • Jaski BE, et al.; Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID) Trial Investigators (2009) Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a firstin-human phase 1/2 clinical trial. J Card Fail 15(3):171-181.
    • (2009) J Card Fail , vol.15 , Issue.3 , pp. 171-181
    • Jaski, B.E.1
  • 26
    • 80053349683 scopus 로고    scopus 로고
    • SUMO1-dependent modulation of SERCA2a in heart failure
    • Kho C, et al. (2011) SUMO1-dependent modulation of SERCA2a in heart failure. Nature 477(7366):601-605.
    • (2011) Nature , vol.477 , Issue.7366 , pp. 601-605
    • Kho, C.1
  • 27
    • 34250832312 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and-beta1 improves contractile function in pressure overload-induced cardiachy pertrophy
    • Belke DD, Gloss B, Swanson EA, Dillmann WH (2007) Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and-beta1 improves contractile function in pressure overload-induced cardiachy pertrophy. Endocrinology 148(6):2870-2877.
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2870-2877
    • Belke, D.D.1    Gloss, B.2    Swanson, E.A.3    Dillmann, W.H.4
  • 28
    • 34047115768 scopus 로고    scopus 로고
    • Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins
    • Sakata S, et al. (2007) Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. J Mol Cell Cardiol 42(4):852-861.
    • (2007) J Mol Cell Cardiol , vol.42 , Issue.4 , pp. 852-861
    • Sakata, S.1
  • 29
    • 36849037512 scopus 로고    scopus 로고
    • Pim-1 regulates cardiomyocyte survival downstream of Akt
    • Muraski JA, et al. (2007) Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med 13(12):1467-1475.
    • (2007) Nat Med , vol.13 , Issue.12 , pp. 1467-1475
    • Muraski, J.A.1
  • 30
    • 52949116043 scopus 로고    scopus 로고
    • Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload
    • Muraski JA, et al. (2008) Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc Natl Acad Sci USA 105(37):13889-13894.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.37 , pp. 13889-13894
    • Muraski, J.A.1
  • 31
    • 77953808996 scopus 로고    scopus 로고
    • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart
    • Carraway MS, et al. (2010) Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. Circ Res 106(11):1722-1730.
    • (2010) Circ Res , vol.106 , Issue.11 , pp. 1722-1730
    • Carraway, M.S.1
  • 32
    • 85027954430 scopus 로고    scopus 로고
    • Preservation of myocardial structure is enhanced by Pim-1 engineering of bone marrow cells
    • Quijada P, et al. (2012) Preservation of myocardial structure is enhanced by Pim-1 engineering of bone marrow cells. Circulation Research 111(1):77-86.
    • (2012) Circulation Research , vol.111 , Issue.1 , pp. 77-86
    • Quijada, P.1
  • 33
    • 79954836097 scopus 로고    scopus 로고
    • Cardiac progenitor cell commitment is inhibited by nuclear Akt expression
    • Fischer KM, et al. (2011) Cardiac progenitor cell commitment is inhibited by nuclear Akt expression. Circ Res 108(8):960-970.
    • (2011) Circ Res , vol.108 , Issue.8 , pp. 960-970
    • Fischer, K.M.1
  • 34
    • 79451471149 scopus 로고    scopus 로고
    • The inotropic peptide βaRKct improves βaR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition
    • Völkers M, et al. (2011) The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition. Circ Res 108(1):27-39.
    • (2011) Circ Res , vol.108 , Issue.1 , pp. 27-39
    • Völkers, M.1
  • 35
    • 79955034417 scopus 로고    scopus 로고
    • Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin
    • Avitabile D, et al. (2011) Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin. Proc Natl Acad Sci USA 108(15):6145-6150.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.15 , pp. 6145-6150
    • Avitabile, D.1
  • 36
    • 84858144597 scopus 로고    scopus 로고
    • Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish
    • Völkers M, et al. (2012) Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish. J Cell Sci 125(Pt 2):287-294.
    • (2012) J Cell Sci , vol.125 , Issue.PART 2 , pp. 287-294
    • Völkers, M.1


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