Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 15, 2011, Pages 6145-6150

  Avitabile, Daniele ^a   Bailey, Brandi ^a   Cottage, Christopher T ^a   Sundararaman, Balaji ^a   Joyo, Anya ^a   McGregor, Michael ^a   Gude, Natalie ^a   Truffa, Silvia ^a   Zarrabi, Aryan ^a   Konstandin, Mathias ^a   Khan, Mohsin ^a   Mohsin, Sadia ^a   Völkers, Mirko ^a   Toko, Haruhiro ^a   Mason, Matt ^a   Cheng, Zhaokang ^a   Din, Shabana ^a   Alvarez, Roberto ^a   Fischer, Kimberlee ^a   Sussman, Mark A ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Hypertrophy; Hypoxia; Nucleolus; rRNA

Indexed keywords

CASPASE 8; DACTINOMYCIN; DOXORUBICIN; NUCLEOLIN; NUCLEOPHOSMIN; NUCLEOSTEMIN; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; CARDIOVASCULAR RESPONSE; CELL CULTURE; CELL PROTECTION; CONFERENCE PAPER; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SILENCING; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE INJURY; NONHUMAN; NUCLEOLAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; RNA SYNTHESIS; STRESS;

MUS; RATTUS;

EID: 79955034417     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017935108     Document Type: Article

References (44)

1. Rubbi CP, Milner J (2003) Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J 22:6068-6077. (Pubitemid 37463250)
2. Leary DJ, Huang S (2001) Regulation of ribosome biogenesis within the nucleolus. FEBS Lett 509:145-150. (Pubitemid 34015932)
3. Huang M, Ji Y, Itahana K, Zhang Y, Mitchell B (2008) Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption. Leuk Res 32: 131-141. (Pubitemid 350103806)
4. Yuan X, et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell 19:77-87. (Pubitemid 40884659)
5. Meng L, Yasumoto H, Tsai RY (2006) Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm. J Cell Sci 119:5124-5136. (Pubitemid 46085191)
6. Tsai RY, McKay RD (2002) A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Genes Dev 16:2991-3003. (Pubitemid 35424188)
7. Kafienah W, Mistry S, Williams C, Hollander AP (2006) Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow. Stem Cells 24: 1113-1120. (Pubitemid 44464744)
8. Maki N, et al. (2007) Rapid accumulation of nucleostemin in nucleolus during newt regeneration. Dev Dyn 236:941-950. (Pubitemid 46641335)
9. Beekman C, et al. (2006) Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development. Mol Cell Biol 26:9291-9301. (Pubitemid 44904424)
10. Zhu Q, Yasumoto H, Tsai RY (2006) Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability. Mol Cell Biol 26:9279-9290. (Pubitemid 44904423)
11. Romanova L, et al. (2009) Critical role of nucleostemin in pre-rRNA processing. J Biol Chem 284:4968-4977.
12. Dai MS, Sun XX, Lu H (2008) Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol 28:4365-4376. (Pubitemid 351904958)
13. Meng L, Lin T, Tsai RY (2008) Nucleoplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survival. J Cell Sci 121:4037-4046.
14. Huang M, Itahana K, Zhang Y, Mitchell BS (2009) Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin. Cancer Res 69:3004-3012.
15. Ma H, Pederson T (2007) Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway. Mol Biol Cell 18:2630-2635. (Pubitemid 47025727)
16. Siddiqi S, et al. (2008) Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res 103:89-97.
17. Ma H, Pederson T (2008) Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells. Mol Biol Cell 19:2870-2875.
18. Li J, et al. (2006) Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem/progenitor cells. J Biol Chem 281:16536-16545.
19. Li J, Zhang X, Sejas DP, Bagby GC, Pang Q (2004) Hypoxia-induced nucleophosmin protects cell death through inhibition of p53. J Biol Chem 279:41275-41279. (Pubitemid 39313565)
20. Yu Y, et al. (2006) Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol 26:3798-3809. (Pubitemid 43726397)
21. Maggi LB, Jr., et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol 28:7050-7065.
22. Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG (2002) Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol 4:529-533. (Pubitemid 34752440)
23. Korgaonkar C, et al. (2005) Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol Cell Biol 25:1258-1271. (Pubitemid 40204905)
24. Parlato R, et al. (2008) Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci 28: 12759-12764.
25. Yao Z, et al. (2010) B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1. Oncogene 29: 1821-1834.
26. Mayer C, Bierhoff H, Grummt I (2005) The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev 19:933-941. (Pubitemid 40548061)
27. Kalita K, Makonchuk D, Gomes C, Zheng JJ, Hetman M (2008) Inhibition of nucleolar transcription as a trigger for neuronal apoptosis. J Neurochem 105:2286-2299. (Pubitemid 351782259)
28. De Angelis A, et al. (2010) Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation 121:276-292.
29. Poortinga G, et al. (2004) MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation. EMBO J 23:3325-3335. (Pubitemid 39209156)
30. Cui C, Tseng H (2004) Estimation of ribosomal RNA transcription rate in situ. Biotechniques 36:134-138. (Pubitemid 38076390)
31. Moffat J, et al. (2006) A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124:1283-1298.
32. Amin MA, Matsunaga S, Uchiyama S, Fukui K (2008) Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells. Biochem J 415: 345-351.
33. Qi W, et al. (2008) NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene 27:4210-4220. (Pubitemid 351969907)
34. Hernandez-Verdun D (2006) Nucleolus: from structure to dynamics. Histochem Cell Biol 125:127-137. (Pubitemid 43049979)
35. Leung AK, Lamond AI (2003) The dynamics of the nucleolus. Crit Rev Eukaryot Gene Expr 13:39-54. (Pubitemid 36834695)
36. Pederson T (1998) The plurifunctional nucleolus. Nucleic Acids Res 26:3871-3876. (Pubitemid 28401334)
37. Shizukuda Y, Matoba S, Mian OY, Nguyen T, Hwang PM (2005) Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice. Mol Cell Biochem 273: 25-32. (Pubitemid 40774760)
38. Liu X, et al. (2004) Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. Am J Physiol Heart Circ Physiol 286:H933-H939. (Pubitemid 38248606)
39. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB (2009) Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol 64:811-827.
40. Jäger D, et al. (2002) The ageing heart: influence of cellular and tissue ageing on total content and distribution of the variants of elongation factor-2. Mech Ageing Dev 123: 1305-1319. (Pubitemid 35247428)
41. Li J, Sejas DP, Burma S, Chen DJ, Pang Q (2007) Nucleophosmin suppresses oncogeneinduced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability. Carcinogenesis 28:1163-1170. (Pubitemid 47062674)
42. MacCallum DE, Hall PA (2000) The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle. J Pathol 190:537-544. (Pubitemid 30164483)
43. Tsujita Y, et al. (2006) Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc Natl Acad Sci USA 103:11946-11951. (Pubitemid 44215791)
44. Krutzik PO, Nolan GP (2003) Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A 55:61-70. (Pubitemid 37522508)