Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells

Experimental Cell Research

Volumn 313, Issue 9, 2007, Pages 1886-1896

  Yamauchi, Junji ^a   Miyamoto, Yuki ^a   Murabe, Mayu ^a   Fujiwara, Yoko ^a   Sanbe, Atsushi ^a   Fujita, Yuko ^b   Murase, Shoko ^b   Tanoue, Akito ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b Biomaster Inc   (Japan)

Author keywords

Gadd45a; JNK; Neurite outgrowth; Paxillin; VPA

Indexed keywords

ALANINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PAXILLIN; ROSCOVITINE; SERINE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRICHOSTATIN A; VALPROIC ACID;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE INDUCTION; HUMAN; HUMAN CELL; NERVE FIBER GROWTH; PRIORITY JOURNAL; PROTEIN FUNCTION;

EID: 34247511439     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.02.019     Document Type: Article

References (32)

1. Manji H.K., Drevets W.C., and Charney D.S. The cellular neurobiology of depression. Nat. Med. 7 (2001) 541-547
2. Coyle J.T., and Duman R.S. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38 (2003) 157-160
3. Huang E.J., and Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 24 (2001) 677-736
4. Bar-Sagi D., and Hall A. Ras and Rho GTPases: a family reunion. Cell 103 (2000) 227-238
5. Yuan P.X., Huang L.D., Jiang Y.M., Gutkind J.S., Manji H.K., and Chen G. The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. J. Biol. Chem. 276 (2001) 31678-31683
6. Einat H., Yuan P.X., Gould T.D., Li J., Du J., Zhang L., Manji H.K., and Chen G. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J. Neurosci. 23 (2004) 7311-7316
7. Yamauchi J., Chan J.R., and Shooter E.M. Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 14421-14426
8. Yamauchi J., Chan J.R., Miyamoto Y., Tsujimoto G., and Shooter E.M. The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5198-5203
9. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 103 (2000) 239-252
10. Takekawa M., and Saito H. A family of stress-inducible GADD45-like proteins mediates activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95 (1998) 521-530
11. Fornace Jr. A.J., Alamo Jr. I., and Hollander M.C. DNA damage-inducible transcripts in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 8800-8804
12. Yamauchi J., Miyamoto Y., Sanbe A., and Tanoue A. JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells. Exp. Cell Res. 312 (2006) 2954-2961
13. Hirose M., Ishizaki T., Watanabe N., Uehata M., Kranenburg O., Moolenaar W.H., Matsumura F., Maekawa M., Bito H., and Narumiya S. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J. Cell Biol. 141 (1998) 1625-1636
14. Gottlicher M., Minucci S., Zhu P., Kramer O.H., Schimpf A., Giavara S., Sleeman J.P., Lo Coco F., Nervi C., Pelicci P.G., and Heinzel T. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 20 (2001) 6969-6978
15. Phiel C.J., Zhang F., Huang E.Y., Guenther M.G., Lazar M.A., and Klein P.S. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 276 (2001) 36734-36741
16. Yoshida M., Kijima M., Akita M., and Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265 (1990) 17174-17179
17. Gray N., Detivaud L., Doerig C., and Meijer L. ATP-site directed inhibitors of cyclin-dependent kinases. Curr. Med. Chem. 6 (1999) 859-875
18. Bain J., McLauchlan H., Elliott M., and Cohen P. The specificities of protein kinase inhibitors: an update. Biochem. J. 371 Part 1 (2003) 199-204
19. Bonny C., Oberson A., Negri S., Sauser C., and Schorderet D.F. Cell-permeable peptide inhibitors of JNK. Diabetes 50 (2001) 77-82
20. Huang C., Rajfur Z., Borchers C.H., Schaller M.D., and Jacobson K. JNK phosphorylates paxillin and regulates cell migration. Nature 424 (2003) 219-223
21. Brown M.C., and Turner C.E. Paxillin: adapting to change. Physiol. Rev. 84 (2004) 1315-1339
22. Hollander M.C., Sheikh M.S., Bulavin D.V., Lundgren K., Augeri-Henmueller L., Shehee R., Molinaro T.A., Kim K.E., Tolosa E., Ashwell J.D., Rosenberg M.P., Zhan Q., Fernandez-Salguero P.M., Morgan W.F., Deng C.X., and Fornace Jr. A.J. Genomic instability in Gadd45a-deficient mice. Nat. Genet. 23 (1999) 176-184
23. Juriloff D.M., and Harris M.J. Mouse models for neural tube closure defects. Hum. Mol. Genet. 9 (2000) 993-1000
24. Wang X., Gorospe M., and Holbrook N.J. Gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress. J. Biol. Chem. 274 (1999) 29599-29602
25. Kuan C.Y., Yang D.D., Samanta Roy D.R., Davis R.J., Rakic P., and Flavell R.A. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22 (1999) 667-676
26. Sabapathy K., Jochum W., Hochedlinger K., Chang L., Karin M., and Wagner E.F. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech. Dev. 89 (1999) 115-124
27. Chi H., Sarkisian M.R., Rakic P., and Flavell R.A. Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 3846-3851
28. Abell A.N., Rivera-Perez J.A., Cuevas B.D., Uhlik M.T., Sather S., Johnson N.L., Minton S.K., Lauder J.M., Winter-Vann A.M., Nakamura K., Magnuson T., Vaillancourt R.R., Heasley L.E., and Johnson G.L. Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol. Cell. Biol. 25 (2005) 8948-8959
29. Ivankovic-Dikic I., Gronroos E., Blaukat A., Barth B.U., and Dikic I. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nat. Cell Biol. 2 (2000) 574-581
30. Webb D.J., Schroeder M.J., Brame C.J., Whitmore L., Shabanowitz J., Hunt D.F., and Horwitz A.R. Paxillin phosphorylation sites mapped by mass spectrometry. J. Cell Sci. 118 Part 21 (2005) 4925-4929
31. Huang C., Borchers C.H., Schaller M.D., and Jacobson K. Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. J. Cell Biol. 164 (2004) 593-602
32. Cai X., Li M., Vrana J., and Schaller M.D. Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. Mol. Cell. Biol. 26 (2006) 2857-2868