IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance

Journal of Leukocyte Biology

Volumn 94, Issue 2, 2013, Pages 291-300

  Xiong, Yanbao ^a   Pennini, Meghan ^a   Vogel, Stefanie N ^a   Medvedev, Andrei E ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Inflammation; Innate immunity; Lipopolysaccharide; Signal transduction; Toll like receptors

Indexed keywords

BETA INTERFERON; ENDOTOXIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME PHOSPHORYLATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING;

INFLAMMATION; INNATE IMMUNITY; LIPOPOLYSACCHARIDE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; DRUG TOLERANCE; ENDOTOXINS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LIPOPROTEINS; MACROPHAGES, PERITONEAL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UBIQUITIN-PROTEIN LIGASES;

EID: 84881005572     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0812401     Document Type: Article

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