Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice

Journal of Immunology

Volumn 190, Issue 1, 2013, Pages 307-316

  Pennini, Meghan E ^a   Perkins, Darren J ^a   Salazar, Andres M ^b   Lipsky, Michael ^a   Vogel, Stefanie N ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Oncovir   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYMETHYLCELLULOSE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MNK1 PROTEIN; MSK1 PROTEIN; POLYINOSINIC POLYCYTIDYLIC ACID; POLYLYSINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE INDUCTION; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS;

ANIMALS; CELLS, CULTURED; CYTOKINES; DOWN-REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PNEUMOCOCCAL INFECTIONS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84871828778     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201644     Document Type: Article

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