The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction

Neurobiology of Disease

Volumn 41, Issue 3, 2011, Pages 614-623

  Kay, Graham W ^a   Jay, Nigel P ^a   Palmer, David N ^a  

^a LINCOLN UNIVERSITY   (New Zealand)

Author keywords

Astrocytes; Batten disease; Fertility; GnRH neurons; Hypothalamic pituitary gonadal axis; Microglia; Neurodegeneration; Sheep model

Indexed keywords

CEROID LIPOFUSCINOSIS NEURONAL PROTEIN 6; FOLLITROPIN; GONADORELIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ATROPHY; CELL ACTIVATION; CELL COUNT; CELL FATE; CELL LOSS; CELL TYPE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FERTILIZATION; GENOTYPE; GLIA CELL; HYPOTHALAMUS; MALE; MEDIAN EMINENCE; MICROGLIA; NERVE CELL; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; OVULATION; PRIORITY JOURNAL; REPRODUCTION; SHEEP; SPERMATOGENESIS;

ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMUS; MALE; MEMBRANE PROTEINS; NERVE DEGENERATION; NEUROGLIA; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS; REPRODUCTION; SHEEP;

EID: 79151479486     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.11.008     Document Type: Article

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