메뉴 건너뛰기




Volumn 1, Issue OCT, 2010, Pages

Anti-inflammatory impact of minocycline in a mouse model of tauopathy

Author keywords

Alzheimer's disease; Array; Cytokine; Immunohistochemistry; Inflammation; Minocycline; Tau

Indexed keywords


EID: 84862779609     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2010.00136     Document Type: Article
Times cited : (98)

References (65)
  • 3
    • 20044367108 scopus 로고    scopus 로고
    • Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    • Andorfer, C., Acker, C. M., Kress, Y., Hof, P. R., Duff, K., and Davies, P. (2005). Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J. Neurosci. 25, 5446-5454.
    • (2005) J. Neurosci. , vol.25 , pp. 5446-5454
    • Andorfer, C.1    Acker, C.M.2    Kress, Y.3    Hof, P.R.4    Duff, K.5    Davies, P.6
  • 5
    • 0025990608 scopus 로고
    • IL-6-mediated events in Alzheimer's disease pathology
    • Bauer, J., Strauss, S. Volk, B., and Berger, M. (1991). IL-6-mediated events in Alzheimer's disease pathology. Immunol. Today 12, 422.
    • (1991) Immunol. Today , vol.12 , pp. 422
    • Bauer, J.1    Strauss, S.2    Volk, B.3    Berger, M.4
  • 6
    • 7244242262 scopus 로고    scopus 로고
    • Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein
    • Bellucci, A., Westwood, A. J., Ingram, E., Casamenti, F., Goedert, M., and Spillantini, M. G. (2004). Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am. J. Pathol. 165, 1643-1652.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1643-1652
    • Bellucci, A.1    Westwood, A.J.2    Ingram, E.3    Casamenti, F.4    Goedert, M.5    Spillantini, M.G.6
  • 9
    • 75949127362 scopus 로고    scopus 로고
    • Inflammation, microglia, and Alzheimer's disease
    • Cameron, B., and Landreth, G. E. (2010). Inflammation, microglia, and Alzheimer's disease. Neurobiol. Dis. 37, 503-509.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 503-509
    • Cameron, B.1    Landreth, G.E.2
  • 11
    • 77249119371 scopus 로고    scopus 로고
    • Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology
    • Choi, C., Jeong, J. H., Jang, J. S., Choi, K., Lee, J., Kwon, J., Choi, K. G., Lee, J. S., and Kang, S. W. (2008). Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology. J. Clin. Neurol. 4, 84-88.
    • (2008) J. Clin. Neurol. , vol.4 , pp. 84-88
    • Choi, C.1    Jeong, J.H.2    Jang, J.S.3    Choi, K.4    Lee, J.5    Kwon, J.6    Choi, K.G.7    Lee, J.S.8    Kang, S.W.9
  • 14
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Dickson, D. W., Lee, S. C., Mattiace, L. A., Yen, S. H., and Brosnan, C. (1993). Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7, 75-83.
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 17
    • 32344450850 scopus 로고    scopus 로고
    • Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation
    • Familian, A., Boshuizen, R. S., Eikelenboom, P., and Veerhuis, R. (2006). Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation. Glia 53, 233-240.
    • (2006) Glia , vol.53 , pp. 233-240
    • Familian, A.1    Boshuizen, R.S.2    Eikelenboom, P.3    Veerhuis, R.4
  • 18
    • 77951689435 scopus 로고    scopus 로고
    • Biomarkers of oxidative damage and inflammation in Alzheimer's disease
    • Galasko, D., and Montine, T. J. (2010). Biomarkers of oxidative damage and inflammation in Alzheimer's disease. Biomark. Med. 4, 27-36.
    • (2010) Biomark. Med. , vol.4 , pp. 27-36
    • Galasko, D.1    Montine, T.J.2
  • 19
    • 34447124582 scopus 로고    scopus 로고
    • RNA and protein-dependent mechanisms in tauopathies: consequences for therapeutic strategies
    • Gallo, J. M., and Noble, W., and Martin, T. R. (2007). RNA and protein-dependent mechanisms in tauopathies: consequences for therapeutic strategies. Cell. Mol. Life Sci. 64, 1701-1714.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 1701-1714
    • Gallo, J.M.1    Noble, W.2    Martin, T.R.3
  • 20
    • 0024211168 scopus 로고
    • Colony-stimulating factors as promoters of ameboid microglia
    • Giulian, D., and Ingeman, J. E. (1988). Colony-stimulating factors as promoters of ameboid microglia. J. Neurosci. 8, 4707-4717.
    • (1988) J. Neurosci. , vol.8 , pp. 4707-4717
    • Giulian, D.1    Ingeman, J.E.2
  • 21
    • 0028926976 scopus 로고
    • Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution
    • Griffin, W. S., Sheng, J. G., Roberts, G. W., and Mrak, R. E. (1995). Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54, 276-281.
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 276-281
    • Griffin, W.S.1    Sheng, J.G.2    Roberts, G.W.3    Mrak, R.E.4
  • 22
    • 61849088424 scopus 로고    scopus 로고
    • Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
    • Hanger, D. P., Anderton, B. H., and Noble, W. (2009a). Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends. Mol. Med. 15, 112-119.
    • (2009) Trends. Mol. Med. , vol.15 , pp. 112-119
    • Hanger, D.P.1    Anderton, B.H.2    Noble, W.3
  • 23
    • 70949100259 scopus 로고    scopus 로고
    • Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease
    • Hanger, D. P., Seereeram, A., and Noble, W. (2009b). Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease. Expert Rev. Neurother. 9, 1647-1666.
    • (2009) Expert Rev. Neurother. , vol.9 , pp. 1647-1666
    • Hanger, D.P.1    Seereeram, A.2    Noble, W.3
  • 25
    • 0029051259 scopus 로고
    • Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients
    • Huell, M., Strauss, S., Volk, B., Berger, M., and Bauer, J. (1995). Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients. Acta Neuropathol. 89, 544-551.
    • (1995) Acta Neuropathol , vol.89 , pp. 544-551
    • Huell, M.1    Strauss, S.2    Volk, B.3    Berger, M.4    Bauer, J.5
  • 26
    • 0030988629 scopus 로고    scopus 로고
    • Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease
    • Ishizuka, K., Kimura, T., Igata-yi, R., Katsuragi, S., Takamatsu, J., and Miyakawa, T. (1997). Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin. Neurosci. 51, 135-138.
    • (1997) Psychiatry Clin. Neurosci. , vol.51 , pp. 135-138
    • Ishizuka, K.1    Kimura, T.2    Igata-yi, R.3    Katsuragi, S.4    Takamatsu, J.5    Miyakawa, T.6
  • 27
    • 45849105153 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent upregulation of cytokines in a transgenic model of Alzheimer's disease
    • Jin, J. J., Kim, H. D., Maxwell, J. A., Li, L., and Fukichi, K. (2008). Toll-like receptor 4-dependent upregulation of cytokines in a transgenic model of Alzheimer's disease. J. Neuroinflamm. 5, 23.
    • (2008) J. Neuroinflamm. , vol.5 , pp. 23
    • Jin, J.J.1    Kim, H.D.2    Maxwell, J.A.3    Li, L.4    Fukichi, K.5
  • 28
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., and Laferla, F. M. (2005). Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 25, 8843-8853.
    • (2005) J. Neurosci. , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    Laferla, F.M.5
  • 29
    • 0036406903 scopus 로고    scopus 로고
    • Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
    • Kriz, J., Nguyen, M. D., and Julien, J. P. (2002). Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 10, 268-278.
    • (2002) Neurobiol. Dis. , vol.10 , pp. 268-278
    • Kriz, J.1    Nguyen, M.D.2    Julien, J.P.3
  • 30
    • 78549247122 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor (M-CSF) in plasma and CSF of patients with mild cognitive impairment and Alzheimer's disease
    • Laske, C., Stransky, E., Hoffmann, N., Maetzler, W., Straten, G., Eschweiler, G. W., and Leyhe, T. (2010). Macrophage colony-stimulating factor (M-CSF) in plasma and CSF of patients with mild cognitive impairment and Alzheimer's disease. Curr. Alzheimer Res. 7, 409-414.
    • (2010) Curr. Alzheimer Res. , vol.7 , pp. 409-414
    • Laske, C.1    Stransky, E.2    Hoffmann, N.3    Maetzler, W.4    Straten, G.5    Eschweiler, G.W.6    Leyhe, T.7
  • 31
    • 0142025464 scopus 로고    scopus 로고
    • Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat
    • Lee, S. M., Yune, T. Y., Kim, S. J., Park, D. W., Lee, Y. K., Kim, Y. C., Oh, Y. J., Markelonis, G. J., and Oh, T. H. (2003). Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J. Neurotrauma 20, 1017-1027.
    • (2003) J. Neurotrauma , vol.20 , pp. 1017-1027
    • Lee, S.M.1    Yune, T.Y.2    Kim, S.J.3    Park, D.W.4    Lee, Y.K.5    Kim, Y.C.6    Oh, Y.J.7    Markelonis, G.J.8    Oh, T.H.9
  • 33
    • 73649129558 scopus 로고    scopus 로고
    • Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice
    • Mastrangelo, M. A., Sudol, K. L., Narrow, W. C., and Bowers, W. J. (2009). Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice. Am. J. Pathol. 175, 2076-2088.
    • (2009) Am. J. Pathol. , vol.175 , pp. 2076-2088
    • Mastrangelo, M.A.1    Sudol, K.L.2    Narrow, W.C.3    Bowers, W.J.4
  • 34
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies
    • McGeer, P. L., Schulzer, M., and McGeer, E. G. (1996). Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47, 425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 36
    • 51349134916 scopus 로고    scopus 로고
    • Astrocytes in multiple sclerosis: a product of their environment
    • Nair, A., Frederick, T. J., and Miller, S. D. (2008). Astrocytes in multiple sclerosis: a product of their environment. Cell. Mol. Life Sci. 65, 2702-2720.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 2702-2720
    • Nair, A.1    Frederick, T.J.2    Miller, S.D.3
  • 37
    • 61449177863 scopus 로고    scopus 로고
    • Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease
    • Noble, W., Garwood, C. J., Stephenson, J., Kinsey, A. M., Hanger, D. P., and Anderton, B. H. (2009a). Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB J. 23, 739-750.
    • (2009) FASEB J , vol.23 , pp. 739-750
    • Noble, W.1    Garwood, C.J.2    Stephenson, J.3    Kinsey, A.M.4    Hanger, D.P.5    Anderton, B.H.6
  • 38
    • 70349573768 scopus 로고    scopus 로고
    • Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding
    • Noble, W., Garwood, C. J., and Hanger, D. P. (2009b). Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding. Prion 3, 78-83.
    • (2009) Prion , vol.3 , pp. 78-83
    • Noble, W.1    Garwood, C.J.2    Hanger, D.P.3
  • 40
    • 57849144282 scopus 로고    scopus 로고
    • Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
    • Ojala, J., Alafuzoff, I., Herukka, S. K., van Groen, T., Tanila H., and Pirttila, T. (2009). Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiol. Aging 30, 198-209.
    • (2009) Neurobiol. Aging , vol.30 , pp. 198-209
    • Ojala, J.1    Alafuzoff, I.2    Herukka, S.K.3    van Groen, T.4    Tanila, H.5    Pirttila, T.6
  • 42
    • 77957357526 scopus 로고    scopus 로고
    • Reductions in amyloidbeta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation
    • Parachikova, A., Visilevko, V., Cribbs, D. H., Laferla, F. M., and Green, K. N. (2010). Reductions in amyloidbeta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J. Alzheimers Dis. 21, 527-542.
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 527-542
    • Parachikova, A.1    Visilevko, V.2    Cribbs, D.H.3    Laferla, F.M.4    Green, K.N.5
  • 43
    • 69449093036 scopus 로고    scopus 로고
    • Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
    • Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E., and Davies, P. (2009). Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J. Neurosci. 29, 10741-10749.
    • (2009) J. Neurosci. , vol.29 , pp. 10741-10749
    • Polydoro, M.1    Acker, C.M.2    Duff, K.3    Castillo, P.E.4    Davies, P.5
  • 44
    • 4544285361 scopus 로고    scopus 로고
    • Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation
    • Pontikis, C. C., Cella, C. V., Parihar, N., Lim, M. J., Chakrabarti, S., Mitchison, H. M., Mobley, W. C., Rezaie, P., Pearce, D. A., and Cooper, J. D. (2004). Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain Res. 1023, 231-242.
    • (2004) Brain Res , vol.1023 , pp. 231-242
    • Pontikis, C.C.1    Cella, C.V.2    Parihar, N.3    Lim, M.J.4    Chakrabarti, S.5    Mitchison, H.M.6    Mobley, W.C.7    Rezaie, P.8    Pearce, D.A.9    Cooper, J.D.10
  • 45
    • 27744565604 scopus 로고    scopus 로고
    • Thalamocortical neuron loss and localized astrocytosis in the Cln3Deltaex7/8 knock-in mouse model of Batten disease
    • Pontikis, C. C., Cotman, S. L., MacDonald, M. E., and Cooper, J. D. (2005). Thalamocortical neuron loss and localized astrocytosis in the Cln3Deltaex7/8 knock-in mouse model of Batten disease. Neurobiol. Dis. 20, 823-836.
    • (2005) Neurobiol. Dis. , vol.20 , pp. 823-836
    • Pontikis, C.C.1    Cotman, S.L.2    MacDonald, M.E.3    Cooper, J.D.4
  • 47
    • 0017327466 scopus 로고
    • Development of the barrels and barrel field in the somatosensory cortex of the mouse
    • Rice, F. L., and Van der Loos, H. (1977). Development of the barrels and barrel field in the somatosensory cortex of the mouse. J. Comp. Neurol. 171, 545-560.
    • (1977) J. Comp. Neurol. , vol.171 , pp. 545-560
    • Rice, F.L.1    Van der Loos, H.2
  • 48
    • 33645733075 scopus 로고    scopus 로고
    • Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood- brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus
    • [Epub 2006 February 9]
    • Ryu, J. K., and McLarnon, J. G. (2006). Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood- brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus. Exp. Neurol. 198, 552-557. [Epub 2006 February 9].
    • (2006) Exp. Neurol. , vol.198 , pp. 552-557
    • Ryu, J.K.1    McLarnon, J.G.2
  • 49
    • 65549149134 scopus 로고    scopus 로고
    • Neuron-glia interactions as therapeutic targets in neurodegeneration
    • Salmina, A. B. (2009). Neuron-glia interactions as therapeutic targets in neurodegeneration. J. Alzheimers Dis. 16, 485-502.
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 485-502
    • Salmina, A.B.1
  • 50
    • 0034998271 scopus 로고    scopus 로고
    • Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    • Sanchez Mejia, R. O., Ona, V. O., Li, M., and Friedlander, R. M. (2001). Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 48, 1393-1399.
    • (2001) Neurosurgery , vol.48 , pp. 1393-1399
    • Sanchez Mejia, R.O.1    Ona, V.O.2    Li, M.3    Friedlander, R.M.4
  • 51
    • 33746652117 scopus 로고    scopus 로고
    • Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits
    • Schindowski, K., Bretteville, A., Leroy, K., Begard, S., Brion, J. P., Hamdane, M., and Buee, L. (2006). Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am. J. Pathol. 169, 599-616.
    • (2006) Am. J. Pathol. , vol.169 , pp. 599-616
    • Schindowski, K.1    Bretteville, A.2    Leroy, K.3    Begard, S.4    Brion, J.P.5    Hamdane, M.6    Buee, L.7
  • 52
    • 77956064235 scopus 로고    scopus 로고
    • Inflammation in transgenic mouse models of neurodegenerative disorders
    • Schwab, C., Klegeris, A., and McGeer, P. L. (2009). Inflammation in transgenic mouse models of neurodegenerative disorders. Biochim. Biophys. Acta. 1802, 889-902.
    • (2009) Biochim. Biophys. Acta. , vol.1802 , pp. 889-902
    • Schwab, C.1    Klegeris, A.2    McGeer, P.L.3
  • 53
    • 33646243562 scopus 로고    scopus 로고
    • Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice
    • Seabrook, T. J., Jiang, L., Maier, M., and Lemere, C. A. (2006). Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia 53, 776-782.
    • (2006) Glia , vol.53 , pp. 776-782
    • Seabrook, T.J.1    Jiang, L.2    Maier, M.3    Lemere, C.A.4
  • 54
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: biology and pathology
    • Sofroniew, M. V., and Vinters, H. V. (2010). Astrocytes: biology and pathology. Acta Neuropathol. 119, 7-35.
    • (2010) Acta Neuropathol , vol.119 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 55
    • 66949146836 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease
    • Sokolova, A., Hill, M. D., Rahimi, F., Warden, L. A., Halliday, G. M., and Shepherd, C. E. (2009). Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease. Brain Pathol. 19, 392-398.
    • (2009) Brain Pathol , vol.19 , pp. 392-398
    • Sokolova, A.1    Hill, M.D.2    Rahimi, F.3    Warden, L.A.4    Halliday, G.M.5    Shepherd, C.E.6
  • 56
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • Stirling, D. P., Khodarahmi, K., Liu, J., McPhail, L. T., McBride, C. B., Steeves, J. D., Ramer, M. S., and Tetzlaff, W. (2004). Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J. Neurosci. 24, 2182-2190.
    • (2004) J. Neurosci. , vol.24 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3    McPhail, L.T.4    McBride, C.B.5    Steeves, J.D.6    Ramer, M.S.7    Tetzlaff, W.8
  • 57
    • 0035132281 scopus 로고    scopus 로고
    • Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia
    • Tarkowski, E., Wallin, A., Regland, B., Blennow, K., and Tarkowski, A. (2001). Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia. Acta Neurol. Scand. 103, 166-174.
    • (2001) Acta Neurol. Scand. , vol.103 , pp. 166-174
    • Tarkowski, E.1    Wallin, A.2    Regland, B.3    Blennow, K.4    Tarkowski, A.5
  • 59
    • 0035152814 scopus 로고    scopus 로고
    • Neurotrophins are required for nerve growth during development
    • Tucker, K. L., Meyer, M., and Barde, Y. A. (2001). Neurotrophins are required for nerve growth during development. Nat. Neurosci. 4, 29-37.
    • (2001) Nat. Neurosci. , vol.4 , pp. 29-37
    • Tucker, K.L.1    Meyer, M.2    Barde, Y.A.3
  • 60
    • 0028102425 scopus 로고
    • S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions
    • Van Eldik, L. J., and Griffin, W. S. (1994). S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions. Biochim. Biophys. Acta 1223, 398-403.
    • (1994) Biochim. Biophys. Acta , vol.1223 , pp. 398-403
    • Van Eldik, L.J.1    Griffin, W.S.2
  • 62
    • 0031848322 scopus 로고    scopus 로고
    • Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
    • Xia, M. Q., Qin, S. X., Wu, L. J., Mackay, C. R., and Hyman, B. T. (1998). Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am. J. Pathol. 153, 31-37.
    • (1998) Am. J. Pathol. , vol.153 , pp. 31-37
    • Xia, M.Q.1    Qin, S.X.2    Wu, L.J.3    Mackay, C.R.4    Hyman, B.T.5
  • 64
    • 0037310563 scopus 로고    scopus 로고
    • Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
    • Zhang, W., Narayanan, M., and Friedlander, R. M. (2003). Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS. Ann. Neurol. 53, 267-270.
    • (2003) Ann. Neurol. , vol.53 , pp. 267-270
    • Zhang, W.1    Narayanan, M.2    Friedlander, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.