메뉴 건너뛰기




Volumn 353, Issue 2, 2013, Pages 253-260

Challenges in the development of glaucoma neuroprotection therapy

Author keywords

Glaucoma; Neuroprotection; Optic neuropathy; Retinopathy; Therapy

Indexed keywords

BRIMONIDINE; CILIARY NEUROTROPHIC FACTOR; ELIPRODIL; GANGLIOSIDE GM1; GLUTAMIC ACID; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; TIMOLOL;

EID: 84880828122     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-013-1584-z     Document Type: Review
Times cited : (21)

References (77)
  • 1
    • 84857108227 scopus 로고    scopus 로고
    • The molecular basis of retinal ganglion cell death in glaucoma
    • 22155051 10.1016/j.preteyeres.2011.11.002 1:CAS:528:DC%2BC38Xis1emu7w%3D
    • Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 31:152-181
    • (2012) Prog Retin Eye Res , vol.31 , pp. 152-181
    • Almasieh, M.1    Wilson, A.M.2    Morquette, B.3    Cueva Vargas, J.L.4    Di Polo, A.5
  • 2
    • 13744250486 scopus 로고    scopus 로고
    • Longitudinal changes in the visual field and optic disc in glaucoma
    • 15708832 10.1016/j.preteyeres.2004.10.002
    • Artes PH, Chauhan BC (2005) Longitudinal changes in the visual field and optic disc in glaucoma. Prog Retin Eye Res 24:333-354
    • (2005) Prog Retin Eye Res , vol.24 , pp. 333-354
    • Artes, P.H.1    Chauhan, B.C.2
  • 3
    • 33644812718 scopus 로고    scopus 로고
    • Visual field progression in glaucoma: Total versus pattern deviation analyses
    • 16303955 10.1167/iovs.05-0827
    • Artes PH, Nicolela MT, LeBlanc RP, Chauhan BC (2005) Visual field progression in glaucoma: total versus pattern deviation analyses. Invest Ophthalmol Vis Sci 46:4600-4606
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 4600-4606
    • Artes, P.H.1    Nicolela, M.T.2    Leblanc, R.P.3    Chauhan, B.C.4
  • 4
    • 0024539495 scopus 로고
    • Morphological and immunohistochemical studies on degenerative changes of the retina and the optic nerve in neonatal rats injected with monosodium-L-glutamate
    • 2750602 1:CAS:528:DyaL1MXltFSmt7k%3D
    • Azuma N, Kawamura M, Kohsaka S (1989) Morphological and immunohistochemical studies on degenerative changes of the retina and the optic nerve in neonatal rats injected with monosodium-L-glutamate. Nippon Ganka Gakkai Zasshi 93:72-79
    • (1989) Nippon Ganka Gakkai Zasshi , vol.93 , pp. 72-79
    • Azuma, N.1    Kawamura, M.2    Kohsaka, S.3
  • 5
    • 33746720274 scopus 로고    scopus 로고
    • Structure-function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry
    • 16799030 10.1167/iovs.05-1489
    • Bowd C, Zangwill LM, Medeiros FA, Tavares IM, Hoffmann EM, Bourne RR, Sample PA, Weinreb RN (2006) Structure-function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry. Invest Ophthalmol Vis Sci 47:2889-2895
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 2889-2895
    • Bowd, C.1    Zangwill, L.M.2    Medeiros, F.A.3    Tavares, I.M.4    Hoffmann, E.M.5    Bourne, R.R.6    Sample, P.A.7    Weinreb, R.N.8
  • 7
    • 70349141320 scopus 로고    scopus 로고
    • A critical discussion of the rates of progression and causes of optic nerve damage in glaucoma: International Glaucoma Think Tank II: July 25-26, 2008, Florence, Italy
    • 19680047 10.1097/IJG.0b013e3181aff461
    • Caprioli J, Zeyen T (2009) A critical discussion of the rates of progression and causes of optic nerve damage in glaucoma: International Glaucoma Think Tank II: July 25-26, 2008, Florence, Italy. J Glaucoma 18:S1-S21
    • (2009) J Glaucoma , vol.18
    • Caprioli, J.1    Zeyen, T.2
  • 10
    • 84866975026 scopus 로고    scopus 로고
    • The longitudinal changes of the visual field in an Asian population with primary angle-closure glaucoma with and without an acute attack
    • 22690869 10.1089/jop.2012.0006
    • Chen YJ, Tai MC, Cheng JH, Chen JT, Chen YH, Lu DW (2012) The longitudinal changes of the visual field in an Asian population with primary angle-closure glaucoma with and without an acute attack. J Ocul Pharmacol Ther 28:529-535
    • (2012) J Ocul Pharmacol Ther , vol.28 , pp. 529-535
    • Chen, Y.J.1    Tai, M.C.2    Cheng, J.H.3    Chen, J.T.4    Chen, Y.H.5    Lu, D.W.6
  • 11
    • 0038132019 scopus 로고    scopus 로고
    • Ophthalmic drug discovery
    • 12776220 10.1038/nrd1106 1:CAS:528:DC%2BD3sXktFOhu78%3D
    • Clark AF, Yorio T (2003) Ophthalmic drug discovery. Nat Rev Drug Discov 2:448-459
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 448-459
    • Clark, A.F.1    Yorio, T.2
  • 12
    • 0027257248 scopus 로고
    • Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro
    • de Araujo EG, Linden R (1993) Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro. Eur J Neurosci 5:1181-1188
    • (1993) Eur J Neurosci , vol.5 , pp. 1181-1188
    • De Araujo, E.G.1    Linden, R.2
  • 13
    • 3142732365 scopus 로고    scopus 로고
    • Detection of glutamate and gamma-aminobutyric acid in vitreous of patients with proliferative diabetic retinopathy
    • 12579648 1:CAS:528:DC%2BD3MXhsVKiug%3D%3D
    • Deng J, Wu DZ, Gao R (2000) Detection of glutamate and gamma-aminobutyric acid in vitreous of patients with proliferative diabetic retinopathy. Yan ke xue bao 16:199-202
    • (2000) Yan Ke Xue Bao , vol.16 , pp. 199-202
    • Deng, J.1    Wu, D.Z.2    Gao, R.3
  • 14
    • 0029915446 scopus 로고    scopus 로고
    • Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma
    • 8600890 10.1001/archopht.1996.01100130295012 1:STN:280: DyaK287ns1Sisw%3D%3D
    • Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA (1996) Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 114:299-305
    • (1996) Arch Ophthalmol , vol.114 , pp. 299-305
    • Dreyer, E.B.1    Zurakowski, D.2    Schumer, R.A.3    Podos, S.M.4    Lipton, S.A.5
  • 15
    • 0031880893 scopus 로고    scopus 로고
    • Promotion of neuronal survival by GM1 ganglioside. Phenomenology and mechanism of action
    • 9668360 10.1111/j.1749-6632.1998.tb09679.x 1:CAS:528:DyaK1cXks12hu7o%3D
    • Ferrari G, Greene LA (1998) Promotion of neuronal survival by GM1 ganglioside. Phenomenology and mechanism of action. Ann N Y Acad Sci 845:263-273
    • (1998) Ann N y Acad Sci , vol.845 , pp. 263-273
    • Ferrari, G.1    Greene, L.A.2
  • 16
    • 84857411923 scopus 로고    scopus 로고
    • Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor
    • 22335803 10.3109/02713683.2011.645105 1:CAS:528:DC%2BC38XisVKjs7Y%3D
    • Furuya T, Pan Z, Kashiwagi K (2012) Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor. Curr Eye Res 37:170-178
    • (2012) Curr Eye Res , vol.37 , pp. 170-178
    • Furuya, T.1    Pan, Z.2    Kashiwagi, K.3
  • 17
    • 0036272780 scopus 로고    scopus 로고
    • Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells
    • 12049586 10.1001/archopht.120.6.797 1:CAS:528:DC%2BD38Xlt1Sjsr0%3D
    • Gao H, Qiao X, Cantor LB, WuDunn D (2002) Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells. Arch Ophthalmol 120:797-803
    • (2002) Arch Ophthalmol , vol.120 , pp. 797-803
    • Gao, H.1    Qiao, X.2    Cantor, L.B.3    Wudunn, D.4
  • 18
    • 66849108722 scopus 로고    scopus 로고
    • Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells: Block by memantine
    • 19136701 10.1167/iovs.08-2103
    • Hare WA, Wheeler L (2009) Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells: block by memantine. Invest Ophthalmol Vis Sci 50:2940-2948
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2940-2948
    • Hare, W.A.1    Wheeler, L.2
  • 19
    • 3242892118 scopus 로고    scopus 로고
    • Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey. II. Structural measures
    • 15277487 10.1167/iovs.03-0567
    • Hare WA, WoldeMussie E, Weinreb RN, Ton H, Ruiz G, Wijono M, Feldmann B, Zangwill L, Wheeler L (2004) Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey. II. Structural measures. Invest Ophthalmol Vis Sci 45:2640-2651
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2640-2651
    • Hare, W.A.1    Woldemussie, E.2    Weinreb, R.N.3    Ton, H.4    Ruiz, G.5    Wijono, M.6    Feldmann, B.7    Zangwill, L.8    Wheeler, L.9
  • 20
    • 0027999431 scopus 로고
    • Color Doppler analysis of ocular vessel blood velocity in normal-tension glaucoma
    • 7977577 1:STN:280:DyaK2M%2FmvVWrtQ%3D%3D
    • Harris A, Sergott RC, Spaeth GL, Katz JL, Shoemaker JA, Martin BJ (1994) Color Doppler analysis of ocular vessel blood velocity in normal-tension glaucoma. Am J Ophthalmol 118:642-649
    • (1994) Am J Ophthalmol , vol.118 , pp. 642-649
    • Harris, A.1    Sergott, R.C.2    Spaeth, G.L.3    Katz, J.L.4    Shoemaker, J.A.5    Martin, B.J.6
  • 21
    • 70549112634 scopus 로고    scopus 로고
    • Natural history of open-angle glaucoma
    • 19854514 10.1016/j.ophtha.2009.06.042
    • Heijl A, Bengtsson B, Hyman L, Leske MC (2009) Natural history of open-angle glaucoma. Ophthalmology 116:2271-2276
    • (2009) Ophthalmology , vol.116 , pp. 2271-2276
    • Heijl, A.1    Bengtsson, B.2    Hyman, L.3    Leske, M.C.4
  • 22
    • 83455213993 scopus 로고    scopus 로고
    • Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma
    • 21861632 10.1089/neu.2011.1928
    • Hellstrom M, Pollett MA, Harvey AR (2011) Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma. J Neurotrauma 28:2475-2483
    • (2011) J Neurotrauma , vol.28 , pp. 2475-2483
    • Hellstrom, M.1    Pollett, M.A.2    Harvey, A.R.3
  • 25
    • 73149117531 scopus 로고    scopus 로고
    • Rodent models of glaucoma
    • 19379796 10.1016/j.brainresbull.2009.04.004
    • Johnson TV, Tomarev SI (2010) Rodent models of glaucoma. Brain Res Bull 81:349-358
    • (2010) Brain Res Bull , vol.81 , pp. 349-358
    • Johnson, T.V.1    Tomarev, S.I.2
  • 26
    • 79960116416 scopus 로고    scopus 로고
    • Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay
    • 21468976 10.1007/978-1-61779-108-6-16 1:CAS:528:DC%2BC3MXntlaktLg%3D
    • Ju WK, Kim KY (2011) Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay. Methods Mol Biol 740:149-156
    • (2011) Methods Mol Biol , vol.740 , pp. 149-156
    • Ju, W.K.1    Kim, K.Y.2
  • 27
    • 59449090421 scopus 로고    scopus 로고
    • Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina
    • 18936150 10.1167/iovs.08-2499
    • Ju WK, Kim KY, Angert M, Duong-Polk KX, Lindsey JD, Ellisman MH, Weinreb RN (2009) Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci 50:707-716
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 707-716
    • Ju, W.K.1    Kim, K.Y.2    Angert, M.3    Duong-Polk, K.X.4    Lindsey, J.D.5    Ellisman, M.H.6    Weinreb, R.N.7
  • 28
    • 0027712813 scopus 로고
    • Silent myocardial ischemia in glaucoma patients
    • 8278174 10.1159/000310398 1:STN:280:DyaK2c7gsV2jtQ%3D%3D
    • Kaiser HJ, Flammer J, Burckhardt D (1993) Silent myocardial ischemia in glaucoma patients. Ophthalmologica 207:6-7
    • (1993) Ophthalmologica , vol.207 , pp. 6-7
    • Kaiser, H.J.1    Flammer, J.2    Burckhardt, D.3
  • 29
    • 0032900575 scopus 로고    scopus 로고
    • Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia
    • 10235551 1:STN:280:DyaK1M3kvFKgsg%3D%3D
    • Kapin MA, Doshi R, Scatton B, DeSantis LM, Chandler ML (1999) Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia. Invest Ophthalmol Vis Sci 40:1177-1182
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1177-1182
    • Kapin, M.A.1    Doshi, R.2    Scatton, B.3    Desantis, L.M.4    Chandler, M.L.5
  • 30
    • 84871679138 scopus 로고    scopus 로고
    • The association between retinal vessel diameter and retinal nerve fiber layer thickness in asymmetric normal tension glaucoma patients
    • 22836774 10.1167/iovs.12-9783
    • Kim JM, Sae Kim M, Ju Jang H, Ho Park K, Caprioli J (2012) The association between retinal vessel diameter and retinal nerve fiber layer thickness in asymmetric normal tension glaucoma patients. Invest Ophthalmol Vis Sci 53:5609-5614
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 5609-5614
    • Kim, J.M.1    Sae Kim, M.2    Ju Jang, H.3    Ho Park, K.4    Caprioli, J.5
  • 31
    • 79952984499 scopus 로고    scopus 로고
    • A randomized trial of brimonidine versus timolol in preserving visual function: Results from the Low-Pressure Glaucoma Treatment Study
    • 21257146 10.1016/j.ajo.2010.09.026 1:CAS:528:DC%2BC3MXjs1WrsL0%3D
    • Krupin T, Liebmann JM, Greenfield DS, Ritch R, Gardiner S (2011) A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study. Am J Ophthalmol 151:671-681
    • (2011) Am J Ophthalmol , vol.151 , pp. 671-681
    • Krupin, T.1    Liebmann, J.M.2    Greenfield, D.S.3    Ritch, R.4    Gardiner, S.5
  • 32
    • 0345072185 scopus 로고    scopus 로고
    • Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia
    • 9579489 1:STN:280:DyaK1c3jvFSqsA%3D%3D
    • Lagreze WA, Knorle R, Bach M, Feuerstein TJ (1998) Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Invest Ophthalmol Vis Sci 39:1063-1066
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1063-1066
    • Lagreze, W.A.1    Knorle, R.2    Bach, M.3    Feuerstein, T.J.4
  • 33
    • 0037310097 scopus 로고    scopus 로고
    • Early glial responses after acute elevated intraocular pressure in rats
    • 12556393 10.1167/iovs.02-0255
    • Lam TT, Kwong JM, Tso MO (2003) Early glial responses after acute elevated intraocular pressure in rats. Invest Ophthalmol Vis Sci 44:638-645
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 638-645
    • Lam, T.T.1    Kwong, J.M.2    Tso, M.O.3
  • 35
    • 67649336413 scopus 로고    scopus 로고
    • Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: A variability and diagnostic performance study
    • 19464061 10.1016/j.ophtha.2009.04.013
    • Leung CK, Cheung CY, Weinreb RN, Qiu Q, Liu S, Li H, Xu G, Fan N, Huang L, Pang CP, Lam DS (2009) Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology 116:1257-1263
    • (2009) Ophthalmology , vol.116 , pp. 1257-1263
    • Leung, C.K.1    Cheung, C.Y.2    Weinreb, R.N.3    Qiu, Q.4    Liu, S.5    Li, H.6    Xu, G.7    Fan, N.8    Huang, L.9    Pang, C.P.10    Lam, D.S.11
  • 36
    • 84872191546 scopus 로고    scopus 로고
    • The effects of excitatory amino acids and their transporters on function and structure of the distal retina in albino rabbits
    • 10.1007/s10633-012-9354-x
    • Levinger E, Zemel E, Perlman I (2012) The effects of excitatory amino acids and their transporters on function and structure of the distal retina in albino rabbits. Doc Ophthalmol 125:249-265
    • (2012) Doc Ophthalmol , vol.125 , pp. 249-265
    • Levinger, E.1    Zemel, E.2    Perlman, I.3
  • 37
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • 7905600 10.1056/NEJM199403033300907 1:CAS:528:DyaK2cXltVGhtbk%3D
    • Lipton SA, Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 38
    • 0035130192 scopus 로고    scopus 로고
    • Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro
    • 11176986 1:CAS:528:DC%2BD3MXhsVCkurk%3D
    • Liu B, Neufeld AH (2001) Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro. Arch Ophthalmol 119:240-245
    • (2001) Arch Ophthalmol , vol.119 , pp. 240-245
    • Liu, B.1    Neufeld, A.H.2
  • 39
    • 84948011844 scopus 로고
    • The toxic effect of sodium L-glutamate on the inner layers of the retina
    • 13443577 10.1001/archopht.1957.00940010205006 1:STN:280: DyaG2s%2FptVensA%3D%3D
    • Lucas DR, Newhouse JP (1957) The toxic effect of sodium L-glutamate on the inner layers of the retina. AMA Arch Ophthalmol 58:193-201
    • (1957) AMA Arch Ophthalmol , vol.58 , pp. 193-201
    • Lucas, D.R.1    Newhouse, J.P.2
  • 41
    • 0022479032 scopus 로고
    • NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
    • 3012362 10.1038/321519a0 1:CAS:528:DyaL28XksFGjs7g%3D
    • MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321:519-522
    • (1986) Nature , vol.321 , pp. 519-522
    • Macdermott, A.B.1    Mayer, M.L.2    Westbrook, G.L.3    Smith, S.J.4    Barker, J.L.5
  • 42
    • 0017370816 scopus 로고
    • Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey
    • 67096 1:STN:280:DyaE2s7msVGrsA%3D%3D
    • Minckler DS, Bunt AH, Johanson GW (1977) Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey. Invest Ophthalmol Vis Sci 16:426-441
    • (1977) Invest Ophthalmol Vis Sci , vol.16 , pp. 426-441
    • Minckler, D.S.1    Bunt, A.H.2    Johanson, G.W.3
  • 43
    • 67349139928 scopus 로고    scopus 로고
    • Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF
    • 19332123 10.1016/j.mcn.2009.03.002
    • Muller A, Hauk TG, Leibinger M, Marienfeld R, Fischer D (2009) Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF. Mol Cell Neurosci 41:233-246
    • (2009) Mol Cell Neurosci , vol.41 , pp. 233-246
    • Muller, A.1    Hauk, T.G.2    Leibinger, M.3    Marienfeld, R.4    Fischer, D.5
  • 44
    • 33748090287 scopus 로고    scopus 로고
    • Target-derived neurotrophins may influence the survival of adult retinal ganglion cells when local neurotrophic support is disrupted: Implications for glaucoma
    • 16806723 10.1016/j.mehy.2006.04.049 1:CAS:528:DC%2BD28XpsVKltbs%3D
    • Murphy JA, Clarke DB (2006) Target-derived neurotrophins may influence the survival of adult retinal ganglion cells when local neurotrophic support is disrupted: implications for glaucoma. Med Hypotheses 67:1208-1212
    • (2006) Med Hypotheses , vol.67 , pp. 1208-1212
    • Murphy, J.A.1    Clarke, D.B.2
  • 45
    • 0034121754 scopus 로고    scopus 로고
    • Concurrent downregulation of a glutamate transporter and receptor in glaucoma
    • 10845620 1:STN:280:DC%2BD3czgt1ansQ%3D%3D
    • Naskar R, Vorwerk CK, Dreyer EB (2000) Concurrent downregulation of a glutamate transporter and receptor in glaucoma. Invest Ophthalmol Vis Sci 41:1940-1944
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 1940-1944
    • Naskar, R.1    Vorwerk, C.K.2    Dreyer, E.B.3
  • 46
    • 0033578378 scopus 로고    scopus 로고
    • Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma
    • 10449799 10.1073/pnas.96.17.9944 1:CAS:528:DyaK1MXlsVymurg%3D
    • Neufeld AH, Sawada A, Becker B (1999) Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc Natl Acad Sci USA 96:9944-9948
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9944-9948
    • Neufeld, A.H.1    Sawada, A.2    Becker, B.3
  • 47
    • 66249085210 scopus 로고    scopus 로고
    • Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned
    • 19141144 10.1111/j.1755-3768.2008.01459.x
    • Osborne NN (2009) Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned. Acta Ophthalmol 87:450-454
    • (2009) Acta Ophthalmol , vol.87 , pp. 450-454
    • Osborne, N.N.1
  • 48
    • 34547887607 scopus 로고    scopus 로고
    • Rodent models for glaucoma retinopathy and optic neuropathy
    • 17700292 10.1097/IJG.0b013e3181405d4f
    • Pang IH, Clark AF (2007) Rodent models for glaucoma retinopathy and optic neuropathy. J Glaucoma 16:483-505
    • (2007) J Glaucoma , vol.16 , pp. 483-505
    • Pang, I.H.1    Clark, A.F.2
  • 49
    • 0032899330 scopus 로고    scopus 로고
    • Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells
    • 10235550 1:STN:280:DyaK1M3kvFKhuw%3D%3D
    • Pang IH, Wexler EM, Nawy S, DeSantis L, Kapin MA (1999) Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells. Invest Ophthalmol Vis Sci 40:1170-1176
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1170-1176
    • Pang, I.H.1    Wexler, E.M.2    Nawy, S.3    Desantis, L.4    Kapin, M.A.5
  • 51
    • 12744250272 scopus 로고    scopus 로고
    • Acute effects of glaucoma medications on rat intraocular pressure
    • 15670799 10.1016/j.exer.2004.09.001 1:CAS:528:DC%2BD2MXms1Gisg%3D%3D
    • Pang IH, Wang WH, Clark AF (2005b) Acute effects of glaucoma medications on rat intraocular pressure. Exp Eye Res 80:207-214
    • (2005) Exp Eye Res , vol.80 , pp. 207-214
    • Pang, I.H.1    Wang, W.H.2    Clark, A.F.3
  • 52
    • 68349133610 scopus 로고    scopus 로고
    • Differential expression of two glutamate transporters, GLAST and GLT-1, in an experimental rat model of glaucoma
    • 19551376 10.1007/s00221-009-1896-0 1:CAS:528:DC%2BD1MXoslens7k%3D
    • Park CK, Cha J, Park SC, Lee PY, Kim JH, Kim HS, Kim SA, Kim IB, Chun MH (2009) Differential expression of two glutamate transporters, GLAST and GLT-1, in an experimental rat model of glaucoma. Exp Brain Res 197:101-109
    • (2009) Exp Brain Res , vol.197 , pp. 101-109
    • Park, C.K.1    Cha, J.2    Park, S.C.3    Lee, P.Y.4    Kim, J.H.5    Kim, H.S.6    Kim, S.A.7    Kim, I.B.8    Chun, M.H.9
  • 54
    • 79959799743 scopus 로고    scopus 로고
    • Endothelin, astrocytes and glaucoma
    • 20849847 10.1016/j.exer.2010.09.006 1:CAS:528:DC%2BC3MXhtF2rtL7I
    • Prasanna G, Krishnamoorthy R, Yorio T (2011) Endothelin, astrocytes and glaucoma. Exp Eye Res 93:170-177
    • (2011) Exp Eye Res , vol.93 , pp. 170-177
    • Prasanna, G.1    Krishnamoorthy, R.2    Yorio, T.3
  • 55
    • 84857236328 scopus 로고    scopus 로고
    • Clinical trials for glaucoma neuroprotection are not impossible
    • 22249238 10.1097/ICU.0b013e32834ff490
    • Quigley HA (2012) Clinical trials for glaucoma neuroprotection are not impossible. Curr Opin Ophthalmol 23:144-154
    • (2012) Curr Opin Ophthalmol , vol.23 , pp. 144-154
    • Quigley, H.A.1
  • 56
    • 0017123773 scopus 로고
    • The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve
    • 60300 1:STN:280:DyaE283lvFGhuw%3D%3D
    • Quigley H, Anderson DR (1976) The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve. Invest Ophthalmol 15:606-616
    • (1976) Invest Ophthalmol , vol.15 , pp. 606-616
    • Quigley, H.1    Anderson, D.R.2
  • 57
    • 0019523221 scopus 로고
    • Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage
    • 6164357 10.1001/archopht.1981.03930010635009 1:STN:280: DyaL3M7otlClsA%3D%3D
    • Quigley HA, Addicks EM, Green WR, Maumenee AE (1981) Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol 99:635-649
    • (1981) Arch Ophthalmol , vol.99 , pp. 635-649
    • Quigley, H.A.1    Addicks, E.M.2    Green, W.R.3    Maumenee, A.E.4
  • 58
    • 0020042426 scopus 로고
    • Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy
    • 7055464 10.1001/archopht.1982.01030030137016 1:STN:280: DyaL387ht1Kquw%3D%3D
    • Quigley HA, Addicks EM, Green WR (1982) Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. Arch Ophthalmol 100:135-146
    • (1982) Arch Ophthalmol , vol.100 , pp. 135-146
    • Quigley, H.A.1    Addicks, E.M.2    Green, W.R.3
  • 60
    • 0028014616 scopus 로고
    • Peripapillary vasoconstriction in the glaucomas and the anterior ischemic optic neuropathies
    • 8291596 1:STN:280:DyaK2c7itFWnsw%3D%3D
    • Rader J, Feuer WJ, Anderson DR (1994) Peripapillary vasoconstriction in the glaucomas and the anterior ischemic optic neuropathies. Am J Ophthal 117:72-80
    • (1994) Am J Ophthal , vol.117 , pp. 72-80
    • Rader, J.1    Feuer, W.J.2    Anderson, D.R.3
  • 62
    • 0027652805 scopus 로고
    • Intraretinal neurotrophic activity prevents the degeneration of ganglion cells in retinal explants
    • 7905330 1:STN:280:DyaK2c7ivFCqsw%3D%3D
    • Rehen SK, Ary-Pires R, Linden R (1993) Intraretinal neurotrophic activity prevents the degeneration of ganglion cells in retinal explants. Braz J Med Biol Res 26:955-959
    • (1993) Braz J Med Biol Res , vol.26 , pp. 955-959
    • Rehen, S.K.1    Ary-Pires, R.2    Linden, R.3
  • 63
    • 65249098513 scopus 로고    scopus 로고
    • Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent: An evidence-based review
    • 19365015 10.1001/archophthalmol.2009.9 1:CAS:528:DC%2BD1MXltVWgu74%3D
    • Saylor M, McLoon LK, Harrison AR, Lee MS (2009) Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent: an evidence-based review. Arch Ophthalmol 127:402-406
    • (2009) Arch Ophthalmol , vol.127 , pp. 402-406
    • Saylor, M.1    McLoon, L.K.2    Harrison, A.R.3    Lee, M.S.4
  • 64
    • 33645864950 scopus 로고    scopus 로고
    • Futility studies: Spending a little to save a lot
    • 16534098 10.1212/01.wnl.0000204644.81956.65
    • Schwid SR, Cutter GR (2006) Futility studies: spending a little to save a lot. Neurology 66:626-627
    • (2006) Neurology , vol.66 , pp. 626-627
    • Schwid, S.R.1    Cutter, G.R.2
  • 65
    • 70349299846 scopus 로고    scopus 로고
    • Diagnostic ability of Fourier-domain vs time-domain optical coherence tomography for glaucoma detection
    • 19589493 10.1016/j.ajo.2009.05.030
    • Sehi M, Grewal DS, Sheets CW, Greenfield DS (2009) Diagnostic ability of Fourier-domain vs time-domain optical coherence tomography for glaucoma detection. Am J Ophthalmol 148:597-605
    • (2009) Am J Ophthalmol , vol.148 , pp. 597-605
    • Sehi, M.1    Grewal, D.S.2    Sheets, C.W.3    Greenfield, D.S.4
  • 66
    • 0030013973 scopus 로고    scopus 로고
    • Analysis of progressive change in automated visual fields in glaucoma
    • 8641844 1:STN:280:DyaK283ksFaitA%3D%3D
    • Smith SD, Katz J, Quigley HA (1996) Analysis of progressive change in automated visual fields in glaucoma. Invest Ophthalmol Vis Sci 37:1419-1428
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 1419-1428
    • Smith, S.D.1    Katz, J.2    Quigley, H.A.3
  • 67
    • 77952578018 scopus 로고    scopus 로고
    • Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss
    • 20091782
    • Son JL, Soto I, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, Marsh-Armstrong N (2010) Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia 58:780-789
    • (2010) Glia , vol.58 , pp. 780-789
    • Son, J.L.1    Soto, I.2    Oglesby, E.3    Lopez-Roca, T.4    Pease, M.E.5    Quigley, H.A.6    Marsh-Armstrong, N.7
  • 68
    • 33645402376 scopus 로고    scopus 로고
    • Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes
    • 16505037 10.1167/iovs.05-0830
    • Stasi K, Nagel D, Yang X, Wang RF, Ren L, Podos SM, Mittag T, Danias J (2006) Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes. Invest Ophthalmol Vis Sci 47:1024-1029
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 1024-1029
    • Stasi, K.1    Nagel, D.2    Yang, X.3    Wang, R.F.4    Ren, L.5    Podos, S.M.6    Mittag, T.7    Danias, J.8
  • 69
    • 0025806264 scopus 로고
    • Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
    • 1680525 10.1016/0006-8993(91)90944-Q 1:CAS:528:DyaK3MXkvVOjsLg%3D
    • Sucher NJ, Lei SZ, Lipton SA (1991) Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Res 551:297-302
    • (1991) Brain Res , vol.551 , pp. 297-302
    • Sucher, N.J.1    Lei, S.Z.2    Lipton, S.A.3
  • 71
    • 0036202327 scopus 로고    scopus 로고
    • Immunohistologic evidence for retinal glial cell changes in human glaucoma
    • 11923250
    • Wang L, Cioffi GA, Cull G, Dong J, Fortune B (2002) Immunohistologic evidence for retinal glial cell changes in human glaucoma. Invest Ophthalmol Vis Sci 43:1088-1094
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 1088-1094
    • Wang, L.1    Cioffi, G.A.2    Cull, G.3    Dong, J.4    Fortune, B.5
  • 72
    • 0036959563 scopus 로고    scopus 로고
    • Autoantibodies in glaucoma
    • 12525965 10.1076/ceyr.25.2.113.10157
    • Wax M, Yang J, Tezel G (2002) Autoantibodies in glaucoma. Curr Eye Res 25:113-116
    • (2002) Curr Eye Res , vol.25 , pp. 113-116
    • Wax, M.1    Yang, J.2    Tezel, G.3
  • 73
    • 80053635820 scopus 로고    scopus 로고
    • Glaucoma research community and FDA look to the future, II: NEI/FDA Glaucoma Clinical Trial Design and Endpoints Symposium: Measures of structural change and visual function
    • 21972262 10.1167/iovs.11-7895
    • Weinreb RN, Kaufman PL (2011) Glaucoma research community and FDA look to the future, II: NEI/FDA Glaucoma Clinical Trial Design and Endpoints Symposium: measures of structural change and visual function. Invest Ophthalmol Vis Sci 52:7842-7851
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 7842-7851
    • Weinreb, R.N.1    Kaufman, P.L.2
  • 74
    • 0029788373 scopus 로고    scopus 로고
    • Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage
    • 8815881 1:CAS:528:DyaK28Xntlartbc%3D
    • Wen R, Cheng T, Li Y, Cao W, Steinberg RH (1996) Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. J Neurosci 16:5986-5992
    • (1996) J Neurosci , vol.16 , pp. 5986-5992
    • Wen, R.1    Cheng, T.2    Li, Y.3    Cao, W.4    Steinberg, R.H.5
  • 75
    • 0035062239 scopus 로고    scopus 로고
    • T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma
    • 11292402 10.1016/S0002-9394(00)00862-X 1:CAS:528:DC%2BD3MXisVWmtL4%3D
    • Yang J, Patil RV, Yu H, Gordon M, Wax MB (2001) T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma. Am J Ophthalmol 131:421-426
    • (2001) Am J Ophthalmol , vol.131 , pp. 421-426
    • Yang, J.1    Patil, R.V.2    Yu, H.3    Gordon, M.4    Wax, M.B.5
  • 76
    • 0035370336 scopus 로고    scopus 로고
    • Activated microglia in the human glaucomatous optic nerve head
    • 11391707 10.1002/jnr.1104 1:CAS:528:DC%2BD3MXktlOmsL4%3D
    • Yuan L, Neufeld AH (2001) Activated microglia in the human glaucomatous optic nerve head. J Neurosci Res 64:523-532
    • (2001) J Neurosci Res , vol.64 , pp. 523-532
    • Yuan, L.1    Neufeld, A.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.