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Volumn 23, Issue 2, 2012, Pages 144-154

Clinical trials for glaucoma neuroprotection are not impossible

Author keywords

Clinical trial; Glaucoma; Neuroprotection

Indexed keywords

BRIMONIDINE; TIMOLOL;

EID: 84857236328     PISSN: 10408738     EISSN: 15317021     Source Type: Journal    
DOI: 10.1097/ICU.0b013e32834ff490     Document Type: Review
Times cited : (67)

References (48)
  • 1
    • 79951956270 scopus 로고    scopus 로고
    • Neuroprotection in glaucoma: Recent and future directions
    • A review of specific issues in the study of glaucoma neuroprotection
    • Danesh-Meyer HV. Neuroprotection in glaucoma: recent and future directions. Curr Opin Ophthalmol 2011; 22:78-86. A review of specific issues in the study of glaucoma neuroprotectio.n.
    • (2011) Curr Opin Ophthalmol , vol.22 , pp. 78-86
    • Danesh-Meyer, H.V.1
  • 3
    • 0032189255 scopus 로고    scopus 로고
    • Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures
    • Collaborative Normal-Tension Glaucoma Study Group. Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Am J Ophthalmol. 1998; 126:487-497.
    • (1998) Am J Ophthalmo.l. , vol.126 , pp. 487-497
  • 4
    • 0036822851 scopus 로고    scopus 로고
    • Reduction of intraocular pressure and glaucoma progression: Results from the Early Manifest Glaucoma Trial
    • Heijl A, Leske MC, Bengtsson B, Hyman L, et al. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 2002; 120:1268-1279. (Pubitemid 36105431)
    • (2002) Archives of Ophthalmology , vol.120 , Issue.10 , pp. 1268-1279
    • Heijl, A.1    Leske, M.C.2    Bengtsson, B.3    Hyman, L.4    Bengtsson, B.5    Hussein, M.6
  • 6
    • 62849106706 scopus 로고    scopus 로고
    • Glaucoma and disability: Which tasks are affected, and at what stage of disease?
    • A review of the functional implications of glaucoma damage
    • Ramulu P. Glaucoma and disability: which tasks are affected, and at what stage of disease? Curr Opin Ophthalmol 2009; 20:92-98. A review of the functional implications of glaucoma damag.e.
    • (2009) Curr Opin Ophthalmol , vol.20 , pp. 92-98
    • Ramulu, P.1
  • 7
    • 47749120638 scopus 로고    scopus 로고
    • Premise and prediction -how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head
    • Burgoyne CF, Downs JC. Premise and prediction -how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head. J Glaucoma 2008; 17:318-328.
    • (2008) J Glaucoma , vol.17 , pp. 318-328
    • Burgoyne, C.F.1    Downs, J.C.2
  • 8
    • 64249105739 scopus 로고    scopus 로고
    • Biomechanics of the optic nerve head
    • Sigal IA, Ethier CR. Biomechanics of the optic nerve head. Exp Eye Res 2009; 88:799-807.
    • (2009) Exp Eye Res , vol.88 , pp. 799-807
    • Sigal, I.A.1    Ethier, C.R.2
  • 10
    • 62849111769 scopus 로고    scopus 로고
    • Ocular perfusion pressure and glaucoma: Clinical trial and epidemiologic findings
    • Leske MC. Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings. Curr Opin Ophthalmol 2009; 20:73-78.
    • (2009) Curr Opin Ophthalmol , vol.20 , pp. 73-78
    • Leske, M.C.1
  • 11
    • 80052788698 scopus 로고    scopus 로고
    • The case for autoimmunity in glaucoma
    • Wax MB. The case for autoimmunity in glaucoma. Exp Eye Res. 2011; 93:187-190.
    • (2011) Exp Eye Re.s. , vol.93 , pp. 187-190
    • Wax, M.B.1
  • 12
    • 0032889607 scopus 로고    scopus 로고
    • Neuronal death in glaucoma
    • DOI 10.1016/S1350-9462(98)00014-7, PII S1350946298000147
    • Quigley HA. Neuronal death in glaucoma. Prog Ret Eye Res 1998; 18:39-57. (Pubitemid 28457038)
    • (1999) Progress in Retinal and Eye Research , vol.18 , Issue.1 , pp. 39-57
    • Quigley, H.A.1
  • 13
    • 78049508657 scopus 로고    scopus 로고
    • Neuroprotection in glaucoma -is there a future role?
    • Baltmr A, Duggan J, Nizaria S, et al. Neuroprotection in glaucoma -is there a future role? Exp Eye Res 2010; 91:554-566.
    • (2010) Exp Eye Res , vol.91 , pp. 554-566
    • Baltmr, A.1    Duggan, J.2    Nizaria, S.3
  • 14
    • 56549118858 scopus 로고    scopus 로고
    • Risk factors for glaucoma onset and progression
    • Coleman AL,Miglior S. Risk factors for glaucoma onset and progression. Surv Ophthalmol 2008; 53 (Suppl 1):S3-S10.
    • (2008) Surv Ophthalmol , vol.53 , Issue.SUPPL. 1
    • Coleman, A.L.1    Miglior, S.2
  • 15
    • 70549112634 scopus 로고    scopus 로고
    • Natural history of open-angle glaucoma
    • Heijl A, Bengtsson B, Hyman L, et al. Natural history of open-angle glaucoma. Ophthalmology 2009; 116:2271-2276.
    • (2009) Ophthalmology , vol.116 , pp. 2271-2276
    • Heijl, A.1    Bengtsson, B.2    Hyman, L.3
  • 16
    • 70349141320 scopus 로고    scopus 로고
    • A critical discussion of the rates of progression and causes of optic nerve damage in glaucoma
    • Caprioli J, Zeyen T. A critical discussion of the rates of progression and causes of optic nerve damage in glaucoma. J Glaucoma 2009; 18:S1-S21.
    • (2009) J Glaucoma , vol.18
    • Caprioli, J.1    Zeyen, T.2
  • 17
    • 39549106321 scopus 로고    scopus 로고
    • Estimating the rate of progressive visual field damage among those with open-angle glaucoma from crosssectional data
    • Broman AT, Quigley HA, West SK, et al. Estimating the rate of progressive visual field damage among those with open-angle glaucoma from crosssectional data. Invest Ophthalmol Vis Sci 2008; 49:66-76.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 66-76
    • Broman, A.T.1    Quigley, H.A.2    West, S.K.3
  • 18
    • 34848853772 scopus 로고    scopus 로고
    • Predictors of long-term progression in the early manifest glaucoma trial
    • DOI 10.1016/j.ophtha.2007.03.016, PII S0161642007002412
    • Leske MC, Heijl A, Hyman L, et al. Predictors of long-term progression in the Early Manifest Glaucoma Trial. Ophthalmology 2007; 114:1965-1972. (Pubitemid 350016362)
    • (2007) Ophthalmology , vol.114 , Issue.11 , pp. 1965-1972
    • Leske, M.C.1    Heijl, A.2    Hyman, L.3    Bengtsson, B.4    Dong, L.5    Yang, Z.6
  • 19
    • 67650432133 scopus 로고    scopus 로고
    • Neuroprotection: Extrapolating from neurologic diseases to the eye
    • Danesh-Meyer HV, Levin LA. Neuroprotection: extrapolating from neurologic diseases to the eye. Am J Ophthalmol 2009; 148:186-191.
    • (2009) Am J Ophthalmol , vol.148 , pp. 186-191
    • Danesh-Meyer, H.V.1    Levin, L.A.2
  • 20
    • 77951184273 scopus 로고    scopus 로고
    • Lost in translation: Bumps in the road between bench and bedside
    • Levin LA, Danesh-Meyer HV. Lost in translation: bumps in the road between bench and bedside. JAMA 2010; 303:1533-1534.
    • (2010) JAMA , vol.303 , pp. 1533-1534
    • Levin, L.A.1    Danesh-Meyer, H.V.2
  • 21
    • 77956564544 scopus 로고    scopus 로고
    • Mechanisms of retinal ganglion cell injury in aging and glaucoma
    • Chrysotomou V, Trounce IA, Crowston J. Mechanisms of retinal ganglion cell injury in aging and glaucoma. Ophthalmic Res 2010; 44:173-178.
    • (2010) Ophthalmic Res , vol.44 , pp. 173-178
    • Chrysotomou, V.1    Trounce, I.A.2    Crowston, J.3
  • 22
    • 77955843469 scopus 로고    scopus 로고
    • Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection
    • Cone FE, Gelman SE, Son JL, et al. Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection. Exp Eye Res 2010; 91:415-424.
    • (2010) Exp Eye Res , vol.91 , pp. 415-424
    • Cone, F.E.1    Gelman, S.E.2    Son, J.L.3
  • 23
    • 0018736594 scopus 로고
    • An analysis of visual acuity, visual fields, and disk cupping in childhood glaucoma
    • Robin AL, Quigley HA, Pollack IP, et al. An analysis of visual acuity, visual fields, and disk cupping in childhood glaucoma. Am J Ophthalmol 1979; 88:847-858. (Pubitemid 10236331)
    • (1979) American Journal of Ophthalmology , vol.88 , Issue.5 , pp. 847-858
    • Robin, A.L.1    Quigley, H.A.2    Pollack, I.P.3
  • 24
    • 64249106218 scopus 로고    scopus 로고
    • Mouse models of retinal ganglion cell death and glaucoma
    • McKinnon SJ, Schlamp CL, Nickells RW. Mouse models of retinal ganglion cell death and glaucoma. Exp Eye Res 2009; 88:816-824.
    • (2009) Exp Eye Res , vol.88 , pp. 816-824
    • McKinnon, S.J.1    Schlamp, C.L.2    Nickells, R.W.3
  • 25
    • 34547887607 scopus 로고    scopus 로고
    • Rodent models for glaucoma retinopathy and optic neuropathy
    • DOI 10.1097/IJG.0b013e3181405d4f, PII 0006119820070800000010
    • Pang I-H, Clark AF. Rodent models for glaucoma retinopathy and optic neuropathy. J Glaucoma 2007; 16:483-505. (Pubitemid 47263052)
    • (2007) Journal of Glaucoma , vol.16 , Issue.5 , pp. 483-505
    • Pang, I.-H.1    Clark, A.F.2
  • 27
    • 77957850977 scopus 로고    scopus 로고
    • ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma
    • Harada C, Namekata K, Guo X, et al. ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma. Cell Death Differ 2010; 17:1751-1759.
    • (2010) Cell Death Differ , vol.17 , pp. 1751-1759
    • Harada, C.1    Namekata, K.2    Guo, X.3
  • 28
    • 48549084132 scopus 로고    scopus 로고
    • Molecular and cell-based approaches for neuroprotection in glaucoma
    • Lebrun-Julien F, DiPolo A. Molecular and cell-based approaches for neuroprotection in glaucoma. Optom Vis Sci 2008; 85:E417-E424.
    • (2008) Optom Vis Sci , vol.85
    • Lebrun-Julien, F.1    Dipolo, A.2
  • 29
    • 65549157079 scopus 로고    scopus 로고
    • CNTF over-expression leads to increased retinal ganglion cell survival in experimental glaucoma
    • Pease ME, Zack DJ, Berlinicke CA, et al. CNTF over-expression leads to increased retinal ganglion cell survival in experimental glaucoma. Invest Ophthalmol Vis Sci 2009; 50:2194-2200.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2194-2200
    • Pease, M.E.1    Zack, D.J.2    Berlinicke, C.A.3
  • 30
    • 34548076604 scopus 로고    scopus 로고
    • Targeting amyloid-beta in glaucoma treatment
    • Guo L, Salt TE, Luong V, et al. Targeting amyloid-beta in glaucoma treatment. PNAS 2007; 104:13444-13449.
    • (2007) PNAS , vol.104 , pp. 13444-13449
    • Guo, L.1    Salt, T.E.2    Luong, V.3
  • 32
    • 1342270103 scopus 로고    scopus 로고
    • Pharmacologic neuroprotection with an inhibitor of nitric oxide synthase for the treatment of glaucoma
    • DOI 10.1016/j.brainresbull.2003.07.005
    • Neufeld AH. Pharmacologic neuroprotection with an inhibitor of nitric oxide synthase for the treatment of glaucoma. Brain Res Bull 2004; 62:455-459. (Pubitemid 38253028)
    • (2004) Brain Research Bulletin , vol.62 , Issue.6 , pp. 455-459
    • Neufeld, A.H.1
  • 33
    • 33645889640 scopus 로고    scopus 로고
    • Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection
    • Levkovitch-Verbin H, Kalev-Landoy M, Habot-Wilner Z, Melamed S. Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection. Arch Ophthalmol 2006; 124:520-526.
    • (2006) Arch Ophthalmol , vol.124 , pp. 520-526
    • Levkovitch-Verbin, H.1    Kalev-Landoy, M.2    Habot-Wilner, Z.3    Melamed, S.4
  • 34
    • 23844451245 scopus 로고    scopus 로고
    • Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma
    • DOI 10.1016/j.ymthe.2005.04.004, PII S1525001605001577
    • Zhou Y, Pernet V, Hauswirth WW, Di Polo A. Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma. Mol Ther 2005; 12:402-412. (Pubitemid 41150125)
    • (2005) Molecular Therapy , vol.12 , Issue.3 , pp. 402-412
    • Zhou, Y.1    Pernet, V.2    Hauswirth, W.W.3    Di Polo, A.4
  • 35
    • 79958818174 scopus 로고    scopus 로고
    • Rasagiline-induced delay of retinal ganglion cell death in experimental glaucoma in rats
    • Levkovitch-Verbin H, Vander S, Melamed S. Rasagiline-induced delay of retinal ganglion cell death in experimental glaucoma in rats. J Glaucoma. 2011; 20:273-277.
    • (2011) J Glaucom.a. , vol.20 , pp. 273-277
    • Levkovitch-Verbin, H.1    Vander, S.2    Melamed, S.3
  • 38
    • 77955614345 scopus 로고    scopus 로고
    • Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
    • Libby RT, Li Y, Savinova OV, et al. Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet 2005; 1:17-26.
    • (2005) PLoS Genet , vol.1 , pp. 17-26
    • Libby, R.T.1    Li, Y.2    Savinova, O.V.3
  • 42
    • 77950961971 scopus 로고    scopus 로고
    • Neuroprotection for treatment of glaucoma in adults
    • doi: 10.1002/14651858.CD006539.pub2
    • Sena DF, Ramchand K, Lindsley K. Neuroprotection for treatment of glaucoma in adults. Cochrane Database Syst Rev. 2010; (2):CD006539. doi: 10.1002/14651858.CD006539.pub2.
    • (2010) Cochrane Database Syst Re.v. , Issue.2
    • Sena, D.F.1    Ramchand, K.2    Lindsley, K.3
  • 43
    • 79952984499 scopus 로고    scopus 로고
    • A randomized trial of brimonidine versus timolol in preserving visual function: Results from the Low-pressure Glaucoma Treatment Study
    • Krupin T, Liebmann JM, Greenfield DS, et al. A randomized trial of brimonidine versus timolol in preserving visual function: Results from the Low-pressure Glaucoma Treatment Study. Am J Ophthalmol 2011; 151:671-681.
    • (2011) Am J Ophthalmol , vol.151 , pp. 671-681
    • Krupin, T.1    Liebmann, J.M.2    Greenfield, D.S.3
  • 44
    • 33645864950 scopus 로고    scopus 로고
    • Futility studies: Spending a little to save a lot
    • DOI 10.1212/01.wnl.0000204644.81956.65, PII 0000611420060314000005
    • Schwid SR, Cutter GR. Futility studies. Spending a little to save a lot. Neurology 2006; 66:626-627. (Pubitemid 43739812)
    • (2006) Neurology , vol.66 , Issue.5 , pp. 626-627
    • Schwid, S.R.1    Cutter, G.R.2
  • 46
    • 26844475953 scopus 로고    scopus 로고
    • Persistence and adherence with topical glaucoma therapy
    • Nordstrom BL, Friedman DS, Mozaffari E, et al. Persistence and adherence with topical glaucoma therapy. Am J Ophthalmol 2005; 140:598-606.
    • (2005) Am J Ophthalmol , vol.140 , pp. 598-606
    • Nordstrom, B.L.1    Friedman, D.S.2    Mozaffari, E.3
  • 48


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