Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells

Archives of Ophthalmology

Volumn 120, Issue 6, 2002, Pages 797-803

  Gao, Hua ^a   Qiao, Xiaoxi ^b   Cantor, Louis B ^a   WuDunn, Darrell ^a  

^a INDIANA UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRIMONIDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; GLAUCOMA; IN SITU HYBRIDIZATION; NEUROPROTECTION; NONHUMAN; OPTIC NERVE DISEASE; OPTIC NERVE INJURY; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL;

EID: 0036272780     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.120.6.797     Document Type: Article

References (41)

1. Number of people with glaucoma worldwide
2. NMDA-receptor antagonist protects neurons from secondary degeneration after partial optic nerve crush
3. Potential neuroprotective therapy for glaucomatous optic neuropathy
4. Glaucomatous neurodegeneration and the concept of neuroprotection
5. Optic nerve degeneration and potential neuroprotection: Implications for glaucoma
6. Hydroxyl radicals generated in vivo kill neurons in the rat spinal cord: Electrophysiological, histological, and neurochemical results
7. Strategies for neuroprotection with glutamate antagonists: Extrapolating from evidence taken from the first stroke and head injury studies
8. Excitatory amino acid receptors and neurodegeneration
9. Central disorders of vision in humans
10. Clinical experience with brimonidine 0.2% and timolol 0.5% in glaucoma and ocular hypertension
11. Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: A review of safety, efficacy, dose response, and dosing studies
12. The role of brimonidine in the treatment of open-angle glaucoma
13. Brimonidine: A new alpha2-adrenoreceptor agonist for glaucoma treatment
14. Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration
15. From the lab to the clinic: Activation of an alpha-2 agonist pathway is neuroprotective in models of retinal and optic nerve injury
16. Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section
17. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo
18. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
19. Regeneration of lesioned rat optic nerve fibers is improved after neutralization of myelin-associated neurite growth inhibitors
20. Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
21. The effect of central and peripheral neuroglia on the regeneration of the optic nerve
22. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
23. Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
24. Protection of the rat retina from ischemic injury by brainderived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor
25. Brain derived neurotrophic factor mRNA expression in the normal and rd mouse retinas
26. Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina
27. Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury
28. Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia
29. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons
30. Basic fibroblast growth factor in retinal development: Differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice
31. Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity
32. Expression of the proto-oncogene, trk, receptors in the developing rat retina
33. TrkA, TrkB and p75 mRNA expression is developmentally regulated in the rat retina
34. Vitreous concentration of topically applied brimonidine tartrate 0.2%
35. Adrenergic and imidazoline receptormediated responses to UK-14,304-18 (brimonidine) in rabbits and monkeys: A species difference
36. Evidence for an amacrine cell system in the ganglion cell layer of the rat retina
37. Multiple promoters direct tissue-specific expression of the rat BDNF gene
38. Differential usage of multiple brainderived neurotrophic factor promoters in the rat brain following neuronal activation
39. Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts
40. The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn
41. Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage