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Volumn 7, Issue 7, 2013, Pages

Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL PROTEIN C RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84880824585     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002306     Document Type: Article
Times cited : (15)

References (54)
  • 1
    • 78649801897 scopus 로고    scopus 로고
    • The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year darwin prospective study
    • Currie BJ, Ward L, Cheng AC, (2010) The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year darwin prospective study. PLoS Negl Trop Dis 4: e900 10.1371/journal.pntd.0000900 [doi].
    • (2010) PLoS Negl Trop Dis , vol.4
    • Currie, B.J.1    Ward, L.2    Cheng, A.C.3
  • 2
    • 17444369030 scopus 로고    scopus 로고
    • Melioidosis: epidemiology, pathophysiology, and management
    • Cheng AC, Currie BJ, (2005) Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 18: 383-416 18/2/383 [pii];10.1128/CMR.18.2.383-416.2005 [doi].
    • (2005) Clin Microbiol Rev , vol.18 , pp. 383-416
    • Cheng, A.C.1    Currie, B.J.2
  • 3
    • 33645065888 scopus 로고    scopus 로고
    • Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
    • Wiersinga WJ, van der Poll T, White NJ, Day NP, Peacock SJ, (2006) Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol 4: 272-282 nrmicro1385 [pii];10.1038/nrmicro1385 [doi].
    • (2006) Nat Rev Microbiol , vol.4 , pp. 272-282
    • Wiersinga, W.J.1    van der Poll, T.2    White, N.J.3    Day, N.P.4    Peacock, S.J.5
  • 5
    • 0038324480 scopus 로고    scopus 로고
    • Melioidosis
    • White NJ, (2003) Melioidosis. Lancet 361: 1715-1722 S0140673603133740 [pii].
    • (2003) Lancet , vol.361 , pp. 1715-1722
    • White, N.J.1
  • 6
    • 84867770813 scopus 로고    scopus 로고
    • Viral research faces clampdown
    • Butler D, (2012) Viral research faces clampdown. Nature 490: 456 490456a [pii];10.1038/490456a [doi].
    • (2012) Nature , vol.490 , pp. 456
    • Butler, D.1
  • 7
    • 74949117097 scopus 로고    scopus 로고
    • Inflammation and coagulation
    • Levi M, van der Poll T, (2010) Inflammation and coagulation. Crit Care Med 38: S26-S34 10.1097/CCM.0b013e3181c98d21 [doi].
    • (2010) Crit Care Med , vol.38
    • Levi, M.1    van der Poll, T.2
  • 8
    • 70350512348 scopus 로고    scopus 로고
    • Coagulation and innate immune responses: can we view them separately?
    • Delvaeye M, Conway EM, (2009) Coagulation and innate immune responses: can we view them separately? Blood 114: 2367-2374 blood-2009-05-199208 [pii];10.1182/blood-2009-05-199208 [doi].
    • (2009) Blood , vol.114 , pp. 2367-2374
    • Delvaeye, M.1    Conway, E.M.2
  • 9
    • 34147119744 scopus 로고    scopus 로고
    • The cytoprotective protein C pathway
    • Mosnier LO, Zlokovic BV, Griffin JH, (2007) The cytoprotective protein C pathway. Blood 109: 3161-3172 blood-2006-09-003004 [pii];10.1182/blood-2006-09-003004 [doi].
    • (2007) Blood , vol.109 , pp. 3161-3172
    • Mosnier, L.O.1    Zlokovic, B.V.2    Griffin, J.H.3
  • 10
    • 0141819138 scopus 로고    scopus 로고
    • The protein C pathway
    • Esmon CT, (2003) The protein C pathway. Chest 124: 26S-32S.
    • (2003) Chest , vol.124
    • Esmon, C.T.1
  • 11
    • 0029790055 scopus 로고    scopus 로고
    • The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
    • Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT, (1996) The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A 93: 10212-10216.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 10212-10216
    • Stearns-Kurosawa, D.J.1    Kurosawa, S.2    Mollica, J.S.3    Ferrell, G.L.4    Esmon, C.T.5
  • 12
    • 33746728293 scopus 로고    scopus 로고
    • The endothelial protein C receptor
    • Esmon CT, (2006) The endothelial protein C receptor. Curr Opin Hematol 13: 382-385 10.1097/01.moh.0000239712.93662.35 [doi];00062752-200609000-00014 [pii].
    • (2006) Curr Opin Hematol , vol.13 , pp. 382-385
    • Esmon, C.T.1
  • 13
    • 34249722192 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
    • Ghosh S, Pendurthi UR, Steinoe A, Esmon CT, Rao LV, (2007) Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 282: 11849-11857 M609283200 [pii];10.1074/jbc.M609283200 [doi].
    • (2007) J Biol Chem , vol.282 , pp. 11849-11857
    • Ghosh, S.1    Pendurthi, U.R.2    Steinoe, A.3    Esmon, C.T.4    Rao, L.V.5
  • 14
    • 33749378618 scopus 로고    scopus 로고
    • Multifunctional specificity of the protein C/activated protein C Gla domain
    • M604966200 [pii], 10.1074/jbc.M604966200
    • Preston RJ, Ajzner E, Razzari C, Karageorgi S, Dua S, et al. (2006) Multifunctional specificity of the protein C/activated protein C Gla domain. J Biol Chem 281: 28850-28857 M604966200 [pii]; doi:[] 10.1074/jbc.M604966200 [doi].
    • (2006) J Biol Chem , vol.281 , pp. 28850-28857
    • Preston, R.J.1    Ajzner, E.2    Razzari, C.3    Karageorgi, S.4    Dua, S.5
  • 15
    • 79953092222 scopus 로고    scopus 로고
    • Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
    • Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, et al. (2011) Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 117: 3199-3208 blood-2010-09-310706 [pii];10.1182/blood-2010-09-310706 [doi].
    • (2011) Blood , vol.117 , pp. 3199-3208
    • Sen, P.1    Gopalakrishnan, R.2    Kothari, H.3    Keshava, S.4    Clark, C.A.5
  • 17
    • 84857064170 scopus 로고    scopus 로고
    • The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling
    • Gleeson EM, O'Donnell JS, Preston RJ, (2011) The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. Cell Mol Life Sci 69: 717-726 10.1007/s00018-011-0825-0 [doi].
    • (2011) Cell Mol Life Sci , vol.69 , pp. 717-726
    • Gleeson, E.M.1    O'Donnell, J.S.2    Preston, R.J.3
  • 18
    • 0030742589 scopus 로고    scopus 로고
    • Identification of functional endothelial protein C receptor in human plasma
    • Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT, (1997) Identification of functional endothelial protein C receptor in human plasma. J Clin Invest 100: 411-418 10.1172/JCI119548 [doi].
    • (1997) J Clin Invest , vol.100 , pp. 411-418
    • Kurosawa, S.1    Stearns-Kurosawa, D.J.2    Hidari, N.3    Esmon, C.T.4
  • 19
    • 0030016347 scopus 로고    scopus 로고
    • The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor
    • Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, He X, Rezaie AR, et al. (1996) The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem 271: 17491-17498.
    • (1996) J Biol Chem , vol.271 , pp. 17491-17498
    • Fukudome, K.1    Kurosawa, S.2    Stearns-Kurosawa, D.J.3    He, X.4    Rezaie, A.R.5
  • 20
    • 0035869411 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor plays an important role in protein C activation in vivo
    • Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT, (2001) Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 97: 1685-1688.
    • (2001) Blood , vol.97 , pp. 1685-1688
    • Taylor Jr., F.B.1    Peer, G.T.2    Lockhart, M.S.3    Ferrell, G.4    Esmon, C.T.5
  • 21
    • 0034145311 scopus 로고    scopus 로고
    • The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
    • Taylor FB Jr, Stearns-Kurosawa DJ, Kurosawa S, Ferrell G, Chang AC, et al. (2000) The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood 95: 1680-1686.
    • (2000) Blood , vol.95 , pp. 1680-1686
    • Taylor Jr., F.B.1    Stearns-Kurosawa, D.J.2    Kurosawa, S.3    Ferrell, G.4    Chang, A.C.5
  • 22
    • 34250758543 scopus 로고    scopus 로고
    • Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia
    • Zheng X, Li W, Song Y, Hu Y, Ferrell GL, et al. (2007) Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia. J Thromb Haemost 5: 1394-1400 JTH02592 [pii];10.1111/j.1538-7836.2007.02592.x [doi].
    • (2007) J Thromb Haemost , vol.5 , pp. 1394-1400
    • Zheng, X.1    Li, W.2    Song, Y.3    Hu, Y.4    Ferrell, G.L.5
  • 23
    • 25144462156 scopus 로고    scopus 로고
    • Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin
    • Li W, Zheng X, Gu J, Hunter J, Ferrell GL, et al. (2005) Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost 3: 1351-1359 JTH1385 [pii];10.1111/j.1538-7836.2005.01385.x [doi].
    • (2005) J Thromb Haemost , vol.3 , pp. 1351-1359
    • Li, W.1    Zheng, X.2    Gu, J.3    Hunter, J.4    Ferrell, G.L.5
  • 24
    • 77956372381 scopus 로고    scopus 로고
    • Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice
    • Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, et al. (2010) Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest 120: 3167-3178 42629 [pii];10.1172/JCI42629 [doi].
    • (2010) J Clin Invest , vol.120 , pp. 3167-3178
    • Kerschen, E.1    Hernandez, I.2    Zogg, M.3    Jia, S.4    Hessner, M.J.5
  • 25
    • 10244250329 scopus 로고    scopus 로고
    • Patients with severe sepsis vary markedly in their ability to generate activated protein C
    • Liaw PC, Esmon CT, Kahnamoui K, Schmidt S, Kahnamoui S, et al. (2004) Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood 104: 3958-3964 10.1182/blood-2004-03-1203 [doi];2004-03-1203 [pii].
    • (2004) Blood , vol.104 , pp. 3958-3964
    • Liaw, P.C.1    Esmon, C.T.2    Kahnamoui, K.3    Schmidt, S.4    Kahnamoui, S.5
  • 26
    • 0031973176 scopus 로고    scopus 로고
    • Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes
    • Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A, Della VP, et al. (1998) Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood 91: 725-727.
    • (1998) Blood , vol.91 , pp. 725-727
    • Kurosawa, S.1    Stearns-Kurosawa, D.J.2    Carson, C.W.3    D'Angelo, A.4    Della, V.P.5
  • 27
    • 79959711141 scopus 로고    scopus 로고
    • Early rise in circulating endothelial protein C receptor correlates with poor outcome in severe sepsis
    • Guitton C, Gerard N, Sebille V, Bretonniere C, Zambon O, et al. (2011) Early rise in circulating endothelial protein C receptor correlates with poor outcome in severe sepsis. Intensive Care Med 37: 950-956 10.1007/s00134-011-2171-y [doi].
    • (2011) Intensive Care Med , vol.37 , pp. 950-956
    • Guitton, C.1    Gerard, N.2    Sebille, V.3    Bretonniere, C.4    Zambon, O.5
  • 28
    • 0035833529 scopus 로고    scopus 로고
    • Dysfunction of endothelial protein C activation in severe meningococcal sepsis
    • Faust SN, Levin M, Harrison OB, Goldin RD, Lockhart MS, et al. (2001) Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med 345: 408-416 10.1056/NEJM200108093450603 [doi].
    • (2001) N Engl J Med , vol.345 , pp. 408-416
    • Faust, S.N.1    Levin, M.2    Harrison, O.B.3    Goldin, R.D.4    Lockhart, M.S.5
  • 29
    • 36048975811 scopus 로고    scopus 로고
    • A comparative study of the protein C pathway in septic and nonseptic patients with organ failure
    • Borgel D, Bornstain C, Reitsma PH, Lerolle N, Gandrille S, et al. (2007) A comparative study of the protein C pathway in septic and nonseptic patients with organ failure. Am J Respir Crit Care Med 176: 878-885 200611-1692OC [pii];10.1164/rccm.200611-1692OC [doi].
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 878-885
    • Borgel, D.1    Bornstain, C.2    Reitsma, P.H.3    Lerolle, N.4    Gandrille, S.5
  • 30
    • 37549065147 scopus 로고    scopus 로고
    • Activation of coagulation with concurrent impairment of anticoagulant mechanisms correlates with a poor outcome in severe melioidosis
    • Wiersinga WJ, Meijers JC, Levi M, van 't Veer C, Day NP, et al. (2008) Activation of coagulation with concurrent impairment of anticoagulant mechanisms correlates with a poor outcome in severe melioidosis. J Thromb Haemost 6: 32-39 JTH2796 [pii];10.1111/j.1538-7836.2007.02796.x [doi].
    • (2008) J Thromb Haemost , vol.6 , pp. 32-39
    • Wiersinga, W.J.1    Meijers, J.C.2    Levi, M.3    van 't Veer, C.4    Day, N.P.5
  • 31
    • 29344470521 scopus 로고    scopus 로고
    • Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei
    • doi:10.1016/j.ijid.2005.06.001
    • LaRosa SP, Opal SM, Utterback B, Yan SC, Helterbrand J, et al. (2006) Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei. Int J Infect Dis 10: 25-31 S1201-9712(05)00140-2 [pii];10.1016/j.ijid.2005.06.001 [doi].
    • (2006) Int J Infect Dis , vol.10 , pp. 25-31
    • LaRosa, S.P.1    Opal, S.M.2    Utterback, B.3    Yan, S.C.4    Helterbrand, J.5
  • 32
    • 82555171691 scopus 로고    scopus 로고
    • Diabetes does not influence activation of coagulation, fibrinolysis or anticoagulant pathways in Gram-negative sepsis (melioidosis)
    • doi:10.1160/TH11-07-0504
    • Koh GC, Meijers JC, Maude RR, Limmathurotsakul D, Day NP, et al. (2011) Diabetes does not influence activation of coagulation, fibrinolysis or anticoagulant pathways in Gram-negative sepsis (melioidosis). Thromb Haemost 106: 1139-1148 11-07-0504 [pii];10.1160/TH11-07-0504 [doi].
    • (2011) Thromb Haemost , vol.106 , pp. 1139-1148
    • Koh, G.C.1    Meijers, J.C.2    Maude, R.R.3    Limmathurotsakul, D.4    Day, N.P.5
  • 33
    • 80053428231 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis)
    • doi:10.1111/j.1538-7836.2011.04473.x
    • Kager LM, Wiersinga WJ, Roelofs JJ, Meijers JC, Levi M, et al. (2011) Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis). J Thromb Haemost 9: 2020-2028 10.1111/j.1538-7836.2011.04473.x [doi].
    • (2011) J Thromb Haemost , vol.9 , pp. 2020-2028
    • Kager, L.M.1    Wiersinga, W.J.2    Roelofs, J.J.3    Meijers, J.C.4    Levi, M.5
  • 34
    • 85027933376 scopus 로고    scopus 로고
    • Endogenous tissue-type plasminogen activator impairs host defense during severe experimental gram-negative sepsis (melioidosis)
    • doi:10.1097/CCM.0b013e31824ea05e
    • Kager LM, Wiersinga WJ, Roelofs JJ, Meijers JC, Levi M, et al. (2012) Endogenous tissue-type plasminogen activator impairs host defense during severe experimental gram-negative sepsis (melioidosis). Crit Care Med 40: 2168-2175 10.1097/CCM.0b013e31824ea05e [doi].
    • (2012) Crit Care Med , vol.40 , pp. 2168-2175
    • Kager, L.M.1    Wiersinga, W.J.2    Roelofs, J.J.3    Meijers, J.C.4    Levi, M.5
  • 35
    • 34547607225 scopus 로고    scopus 로고
    • Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)
    • doi:10.1371/journal.pmed.0040248
    • Wiersinga WJ, Wieland CW, Dessing MC, Chantratita N, Cheng AC, et al. (2007) Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med 4: e248 06-PLME-RA-0761 [pii];10.1371/journal.pmed.0040248 [doi].
    • (2007) PLoS Med , vol.4
    • Wiersinga, W.J.1    Wieland, C.W.2    Dessing, M.C.3    Chantratita, N.4    Cheng, A.C.5
  • 36
    • 0037389094 scopus 로고    scopus 로고
    • 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    • doi:10.1097/01.CCM.0000050454.01978.3B
    • Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, et al. (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31: 1250-1256 10.1097/01.CCM.0000050454.01978.3B [doi].
    • (2003) Crit Care Med , vol.31 , pp. 1250-1256
    • Levy, M.M.1    Fink, M.P.2    Marshall, J.C.3    Abraham, E.4    Angus, D.5
  • 37
    • 27144449028 scopus 로고    scopus 로고
    • Extraembryonic expression of EPCR is essential for embryonic viability
    • doi:10.1182/blood-2005-01-0406
    • Li W, Zheng X, Gu JM, Ferrell GL, Brady M, et al. (2005) Extraembryonic expression of EPCR is essential for embryonic viability. Blood 106: 2716-2722 2005-01-0406 [pii];10.1182/blood-2005-01-0406 [doi].
    • (2005) Blood , vol.106 , pp. 2716-2722
    • Li, W.1    Zheng, X.2    Gu, J.M.3    Ferrell, G.L.4    Brady, M.5
  • 38
    • 0034161458 scopus 로고    scopus 로고
    • Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
    • Gu JM, Katsuura Y, Ferrell GL, Grammas P, Esmon CT, (2000) Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 95: 1687-1693.
    • (2000) Blood , vol.95 , pp. 1687-1693
    • Gu, J.M.1    Katsuura, Y.2    Ferrell, G.L.3    Grammas, P.4    Esmon, C.T.5
  • 39
    • 0036336456 scopus 로고    scopus 로고
    • Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development
    • Crawley JT, Gu JM, Ferrell G, Esmon CT, (2002) Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development. Thromb Haemost 88: 259-266.
    • (2002) Thromb Haemost , vol.88 , pp. 259-266
    • Crawley, J.T.1    Gu, J.M.2    Ferrell, G.3    Esmon, C.T.4
  • 40
    • 0032708938 scopus 로고    scopus 로고
    • Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
    • doi:10.1086/315155
    • Lauw FN, Simpson AJ, Prins JM, Smith MD, Kurimoto M, et al. (1999) Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis. J Infect Dis 180: 1878-1885 JID990606 [pii];10.1086/315155 [doi].
    • (1999) J Infect Dis , vol.180 , pp. 1878-1885
    • Lauw, F.N.1    Simpson, A.J.2    Prins, J.M.3    Smith, M.D.4    Kurimoto, M.5
  • 41
    • 0842307339 scopus 로고    scopus 로고
    • A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis
    • doi:10.1182/blood-2003-07-2520
    • Saposnik B, Reny JL, Gaussem P, Emmerich J, Aiach M, et al. (2004) A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis. Blood 103: 1311-1318 10.1182/blood-2003-07-2520 [doi];2003-07-2520 [pii].
    • (2004) Blood , vol.103 , pp. 1311-1318
    • Saposnik, B.1    Reny, J.L.2    Gaussem, P.3    Emmerich, J.4    Aiach, M.5
  • 42
    • 0023755932 scopus 로고
    • Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
    • Conway EM, Rosenberg RD, (1988) Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 8: 5588-5592.
    • (1988) Mol Cell Biol , vol.8 , pp. 5588-5592
    • Conway, E.M.1    Rosenberg, R.D.2
  • 43
    • 0024589205 scopus 로고
    • Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture
    • Moore KL, Esmon CT, Esmon NL, (1989) Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 73: 159-165.
    • (1989) Blood , vol.73 , pp. 159-165
    • Moore, K.L.1    Esmon, C.T.2    Esmon, N.L.3
  • 44
    • 0027943163 scopus 로고
    • Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
    • Fukudome K, Esmon CT, (1994) Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 269: 26486-26491.
    • (1994) J Biol Chem , vol.269 , pp. 26486-26491
    • Fukudome, K.1    Esmon, C.T.2
  • 45
    • 0025967559 scopus 로고
    • Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol ester
    • Archipoff G, Beretz A, Freyssinet JM, Klein-Soyer C, Brisson C, et al. (1991) Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol ester. Biochem J 273 (Pt 3):: 679-684.
    • (1991) Biochem J , vol.273 , Issue.Pt 3 , pp. 679-684
    • Archipoff, G.1    Beretz, A.2    Freyssinet, J.M.3    Klein-Soyer, C.4    Brisson, C.5
  • 46
    • 0034009976 scopus 로고    scopus 로고
    • Metalloproteolytic release of endothelial cell protein C receptor
    • Xu J, Qu D, Esmon NL, Esmon CT, (2000) Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem 275: 6038-6044.
    • (2000) J Biol Chem , vol.275 , pp. 6038-6044
    • Xu, J.1    Qu, D.2    Esmon, N.L.3    Esmon, C.T.4
  • 47
    • 0036905914 scopus 로고    scopus 로고
    • Activation of protein C pathway in the airways
    • doi:10.1007/s004080000080
    • Hataji O, Taguchi O, Gabazza EC, Yuda H, Fujimoto H, et al. (2002) Activation of protein C pathway in the airways. Lung 180: 47-59 10.1007/s004080000080 [doi].
    • (2002) Lung , vol.180 , pp. 47-59
    • Hataji, O.1    Taguchi, O.2    Gabazza, E.C.3    Yuda, H.4    Fujimoto, H.5
  • 48
    • 0038290189 scopus 로고    scopus 로고
    • Activated protein C inhibits the expression of platelet-derived growth factor in the lung
    • doi:10.1164/rccm.200206-515OC
    • Shimizu S, Gabazza EC, Taguchi O, Yasui H, Taguchi Y, et al. (2003) Activated protein C inhibits the expression of platelet-derived growth factor in the lung. Am J Respir Crit Care Med 167: 1416-1426 10.1164/rccm.200206-515OC [doi];167/10/1416 [pii].
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1416-1426
    • Shimizu, S.1    Gabazza, E.C.2    Taguchi, O.3    Yasui, H.4    Taguchi, Y.5
  • 49
    • 67049099316 scopus 로고    scopus 로고
    • Activated protein C protects against ventilator-induced pulmonary capillary leak
    • doi:10.1152/ajplung.90555.2008
    • Finigan JH, Boueiz A, Wilkinson E, Damico R, Skirball J, et al. (2009) Activated protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol Lung Cell Mol Physiol 296: L1002-L1011 90555.2008 [pii];10.1152/ajplung.90555.2008 [doi].
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296
    • Finigan, J.H.1    Boueiz, A.2    Wilkinson, E.3    Damico, R.4    Skirball, J.5
  • 50
    • 35948934636 scopus 로고    scopus 로고
    • Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    • doi:10.1038/nm1667
    • Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, et al. (2007) Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 13: 1349-1358 nm1667 [pii];10.1038/nm1667 [doi].
    • (2007) Nat Med , vol.13 , pp. 1349-1358
    • Isermann, B.1    Vinnikov, I.A.2    Madhusudhan, T.3    Herzog, S.4    Kashif, M.5
  • 51
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • doi:10.1073/pnas.1222878110
    • Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, et al. (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 110: 3507-3512 1222878110 [pii];10.1073/pnas.1222878110 [doi].
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 3507-3512
    • Seok, J.1    Warren, H.S.2    Cuenca, A.G.3    Mindrinos, M.N.4    Baker, H.V.5
  • 52
    • 0034048834 scopus 로고    scopus 로고
    • Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis
    • doi:10.1086/315271
    • Simpson AJ, Smith MD, Weverling GJ, Suputtamongkol Y, Angus BJ, et al. (2000) Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. J Infect Dis 181: 621-625 JID990893 [pii];10.1086/315271 [doi].
    • (2000) J Infect Dis , vol.181 , pp. 621-625
    • Simpson, A.J.1    Smith, M.D.2    Weverling, G.J.3    Suputtamongkol, Y.4    Angus, B.J.5
  • 53
    • 0345161549 scopus 로고    scopus 로고
    • Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei
    • Santanirand P, Harley VS, Dance DA, Drasar BS, Bancroft GJ, (1999) Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei. Infect Immun 67: 3593-3600.
    • (1999) Infect Immun , vol.67 , pp. 3593-3600
    • Santanirand, P.1    Harley, V.S.2    Dance, D.A.3    Drasar, B.S.4    Bancroft, G.J.5
  • 54
    • 15244358108 scopus 로고    scopus 로고
    • A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse
    • doi:10.1182/blood-2004-06-2456
    • Iwaki T, Cruz DT, Martin JA, Castellino FJ, (2005) A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood 105: 2364-2371 2004-06-2456 [pii];10.1182/blood-2004-06-2456 [doi].
    • (2005) Blood , vol.105 , pp. 2364-2371
    • Iwaki, T.1    Cruz, D.T.2    Martin, J.A.3    Castellino, F.J.4


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