메뉴 건너뛰기




Volumn 37, Issue 6, 2011, Pages 950-956

Early rise in circulating endothelial protein C receptor correlates with poor outcome in severe sepsis

Author keywords

Gender; Infection; Severe sepsis; Soluble EPCR; Survival analysis

Indexed keywords

CORTICOSTEROID; DROTRECOGIN; ENDOTHELIAL PROTEIN C RECEPTOR; HYDROCORTISONE;

EID: 79959711141     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-011-2171-y     Document Type: Article
Times cited : (24)

References (36)
  • 1
    • 0036957150 scopus 로고    scopus 로고
    • Protein C pathway in sepsis
    • CT Esmon 2002 Protein C pathway in sepsis Ann Med 34 598 605 12553500 10.1080/078538902321117823 1:CAS:528:DC%2BD3sXhs1WgurY%3D (Pubitemid 36113819)
    • (2002) Annals of Medicine , vol.34 , Issue.7-8 , pp. 598-605
    • Esmon, C.T.1
  • 2
    • 2942517677 scopus 로고    scopus 로고
    • Role of tissue factor in hemostasis, thrombosis, and vascular development
    • DOI 10.1161/01.ATV.0000130465.23430.74
    • N Mackman 2004 Role of tissue factor in hemostasis, thrombosis, and vascular development Arterioscler Thromb Vasc Biol 24 1015 1022 15117736 10.1161/01.ATV.0000130465.23430.74 1:CAS:528:DC%2BD2cXkt1Ogtrk%3D (Pubitemid 38737825)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.6 , pp. 1015-1022
    • Mackman, N.1
  • 3
    • 0027943163 scopus 로고
    • Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
    • K Fukudome CT Esmon 1994 Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor J Biol Chem 269 26486 26491 7929370 1:CAS:528:DyaK2cXmslensLk%3D (Pubitemid 24328474)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.42 , pp. 26486-26491
    • Fukudome, K.1    Esmon, C.T.2
  • 4
    • 0035815747 scopus 로고    scopus 로고
    • Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis
    • DOI 10.1074/jbc.C100017200
    • DE Joyce L Gelbert A Ciaccia B DeHoff BW Grinnell 2001 Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis J Biol Chem 276 11199 11203 11278252 10.1074/jbc.C100017200 1:CAS:528:DC%2BD3MXjvFGjsL0%3D (Pubitemid 38089304)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.14 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3    DeHoff, B.4    Grinnell, B.W.5
  • 5
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • DOI 10.1126/science.1071699
    • M Riewald RJ Petrovan A Donner BM Mueller W Ruf 2002 Activation of endothelial cell protease activated receptor 1 by the protein C pathway Science 296 1880 1882 12052963 10.1126/science.1071699 1:CAS:528:DC%2BD38XksVWnurw%3D (Pubitemid 34596276)
    • (2002) Science , vol.296 , Issue.5574 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 6
    • 33746017989 scopus 로고    scopus 로고
    • Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells
    • DOI 10.1074/jbc.M600506200
    • C Feistritzer RA Schuepbach LO Mosnier LA Bush E Di Cera JH Griffin M Riewald 2006 Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells J Biol Chem 281 20077 20084 16709569 10.1074/jbc.M600506200 1:CAS:528:DC%2BD28XmvFeqsbc%3D (Pubitemid 44065782)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.29 , pp. 20077-20084
    • Feistritzer, C.1    Schuepbach, R.A.2    Mosnier, L.O.3    Bush, L.A.4    Di Cera, E.5    Griffin, J.H.6    Riewald, M.7
  • 8
    • 34249722192 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
    • DOI 10.1074/jbc.M609283200
    • S Ghosh UR Pendurthi A Steinoe CT Esmon LV Rao 2007 Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium J Biol Chem 282 11849 11857 17327234 10.1074/jbc.M609283200 1:CAS:528: DC%2BD2sXktFelsr8%3D (Pubitemid 47100682)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.16 , pp. 11849-11857
    • Ghosh, S.1    Pendurthi, U.R.2    Steinoe, A.3    Esmon, C.T.4    Mohan Rao, L.V.5
  • 9
    • 34548076281 scopus 로고    scopus 로고
    • Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity
    • DOI 10.1111/j.1538-7836.2007.02648.x
    • J Lopez-Sagaseta R Montes C Puy N Diez K Fukudome J Hermida 2007 Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity J Thromb Haemost 5 1817 1824 17723119 10.1111/j.1538-7836.2007.02648.x 1:CAS:528:DC%2BD2sXhtFahtLzL (Pubitemid 47288936)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.9 , pp. 1817-1824
    • Lopez-Sagaseta, J.1    Montes, R.2    Puy, C.3    Diez, N.4    Fukudome, K.5    Hermida, J.6
  • 10
    • 0030776168 scopus 로고    scopus 로고
    • Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
    • Z Laszik A Mitro FB Taylor Jr G Ferrell CT Esmon 1997 Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway Circulation 96 3633 3640 9396465 1:CAS:528:DyaK2sXnslyitL0%3D (Pubitemid 27513443)
    • (1997) Circulation , vol.96 , Issue.10 , pp. 3633-3640
    • Laszik, Z.1    Mitro, A.2    Taylor Jr., F.B.3    Ferrell, G.4    Esmon, C.T.5
  • 11
    • 0037044806 scopus 로고    scopus 로고
    • Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality
    • DOI 10.1074/jbc.M207538200
    • JM Gu JT Crawley G Ferrell F Zhang W Li NL Esmon CT Esmon 2002 Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality J Biol Chem 277 43335 43343 12218060 10.1074/jbc.M207538200 1:CAS:528:DC%2BD38Xos1emsLk%3D (Pubitemid 35285721)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.45 , pp. 43335-43343
    • Gu, J.-M.1    Crawley, J.T.B.2    Ferrell, G.3    Zhang, F.4    Li, W.5    Esmon, N.L.6    Esmon, C.T.7
  • 12
    • 0031973176 scopus 로고    scopus 로고
    • Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes [3]
    • S Kurosawa DJ Stearns-Kurosawa CW Carson A D'Angelo P Della Valle CT Esmon 1998 Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes Blood 91 725 727 9427734 1:CAS:528:DyaK1cXjsVWgsg%3D%3D (Pubitemid 28053403)
    • (1998) Blood , vol.91 , Issue.2 , pp. 725-727
    • Kurosawa, S.1    Stearns-Kurosawa, D.J.2    Carson, C.W.3    D'Angelo, A.4    Della Valle, P.5    Esmon, C.T.6
  • 13
    • 0034009976 scopus 로고    scopus 로고
    • Metalloproteolytic release of endothelial cell protein C receptor
    • DOI 10.1074/jbc.275.8.6038
    • J Xu D Qu NL Esmon CT Esmon 2000 Metalloproteolytic release of endothelial cell protein C receptor J Biol Chem 275 6038 6044 10681599 10.1074/jbc.275.8.6038 1:CAS:528:DC%2BD3cXhsFKrsrg%3D (Pubitemid 30115255)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.8 , pp. 6038-6044
    • Xu, J.1    Qu, D.2    Esmon, N.L.3    Esmon, C.T.4
  • 14
    • 33846452573 scopus 로고    scopus 로고
    • Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-α converting enzyme/ADAM17
    • DOI 10.1111/j.1538-7836.2007.02347.x
    • D Qu Y Wang NL Esmon CT Esmon 2007 Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17 J Thromb Haemost 5 395 402 17155946 10.1111/j.1538-7836.2007. 02347.x 1:CAS:528:DC%2BD2sXis1SgtLg%3D (Pubitemid 46139466)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.2 , pp. 395-402
    • Qu, D.1    Wang, Y.2    Esmon, N.L.3    Esmon, C.T.4
  • 15
    • 43549096946 scopus 로고    scopus 로고
    • Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma
    • 18073349 10.1182/blood-2007-08-104968 1:CAS:528:DC%2BD1cXktlWms70%3D
    • B Saposnik E Lesteven A Lokajczyk CT Esmon M Aiach S Gandrille 2008 Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma Blood 111 3442 3451 18073349 10.1182/blood-2007-08-104968 1:CAS:528:DC%2BD1cXktlWms70%3D
    • (2008) Blood , vol.111 , pp. 3442-3451
    • Saposnik, B.1    Lesteven, E.2    Lokajczyk, A.3    Esmon, C.T.4    Aiach, M.5    Gandrille, S.6
  • 16
    • 0034050886 scopus 로고    scopus 로고
    • Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function
    • DOI 10.1074/jbc.275.8.5447
    • PC Liaw PF Neuenschwander MD Smirnov CT Esmon 2000 Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function J Biol Chem 275 5447 5452 10681521 10.1074/jbc.275.8.5447 1:CAS:528:DC%2BD3cXhsFKksLk%3D (Pubitemid 30115177)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.8 , pp. 5447-5452
    • Liaw, P.C.Y.1    Neuenschwander, P.F.2    Smirnov, M.D.3    Esmon, C.T.4
  • 17
    • 33746728293 scopus 로고    scopus 로고
    • The endothelial protein C receptor
    • DOI 10.1097/01.moh.0000239712.93662.35, PII 0006275220060900000014
    • CT Esmon 2006 The endothelial protein C receptor Curr Opin Hematol 13 382 385 16888445 10.1097/01.moh.0000239712.93662.35 1:CAS:528:DC%2BD28XhtVSrs77J (Pubitemid 44168461)
    • (2006) Current Opinion in Hematology , vol.13 , Issue.5 , pp. 382-385
    • Esmon, C.T.1
  • 18
    • 0842307339 scopus 로고    scopus 로고
    • A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis
    • DOI 10.1182/blood-2003-07-2520
    • B Saposnik JL Reny P Gaussem J Emmerich M Aiach S Gandrille 2004 A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis Blood 103 1311 1318 14576048 10.1182/blood-2003-07-2520 1:CAS:528:DC%2BD2cXhsVSltLs%3D (Pubitemid 38168642)
    • (2004) Blood , vol.103 , Issue.4 , pp. 1311-1318
    • Saposnik, B.1    Reny, J.-L.2    Gaussem, P.3    Emmerich, J.4    Aiach, M.5    Gandrille, S.6
  • 19
    • 33644649032 scopus 로고    scopus 로고
    • Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants
    • DOI 10.1016/j.thromres.2005.04.029, PII S0049384805002069
    • P Simioni O Morboeuf G Tognin S Gavasso D Tormene B Woodhams A Pagnan 2006 Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants Thromb Res 117 523 528 15921724 10.1016/j.thromres.2005.04.029 1:CAS:528: DC%2BD28XitValtbs%3D (Pubitemid 43326137)
    • (2006) Thrombosis Research , vol.117 , Issue.5 , pp. 523-528
    • Simioni, P.1    Morboeuf, O.2    Tognin, G.3    Gavasso, S.4    Tormene, D.5    Woodhams, B.6    Pagnan, A.7
  • 20
    • 0026874127 scopus 로고
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • American College of Chest Physicians/Society of Critical Care Medicine
    • American College of Chest Physicians/Society of Critical Care Medicine (1992) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874
    • (1992) Crit Care Med , vol.20 , pp. 864-874
  • 21
    • 33947589232 scopus 로고    scopus 로고
    • Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation
    • DOI 10.1182/blood-2006-06-030213
    • S Coupel A Moreau M Hamidou V Horejsi JP Soulillou B Charreau 2007 Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation Blood 109 2806 2814 17179229 1:CAS:528: DC%2BD2sXjvVyns7w%3D (Pubitemid 46482075)
    • (2007) Blood , vol.109 , Issue.7 , pp. 2806-2814
    • Coupel, S.1    Moreau, A.2    Hamidou, M.3    Horejsi, V.4    Soulillou, J.-P.5    Charreau, B.6
  • 22
    • 0038683379 scopus 로고    scopus 로고
    • Coagulation and inflammation
    • DOI 10.1179/096805103125001603
    • CT Esmon 2003 Coagulation and inflammation J Endotoxin Res 9 192 198 12831462 1:CAS:528:DC%2BD3sXlsFajs7w%3D (Pubitemid 36722600)
    • (2003) Journal of Endotoxin Research , vol.9 , Issue.3 , pp. 192-198
    • Esmon, C.T.1
  • 23
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • DOI 10.1182/blood-2002-06-1887
    • WC Aird 2003 The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome Blood 101 3765 3777 12543869 10.1182/blood-2002-06- 1887 1:CAS:528:DC%2BD3sXktVGnt78%3D (Pubitemid 36857845)
    • (2003) Blood , vol.101 , Issue.10 , pp. 3765-3777
    • Aird, W.C.1
  • 25
    • 0035869411 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor plays an important role in protein C activation in vivo
    • DOI 10.1182/blood.V97.6.1685
    • FB Taylor Jr GT Peer MS Lockhart G Ferrell CT Esmon 2001 Endothelial cell protein C receptor plays an important role in protein C activation in vivo Blood 97 1685 1688 11238108 10.1182/blood.V97.6.1685 1:CAS:528: DC%2BD3MXitFaltL0%3D (Pubitemid 32217234)
    • (2001) Blood , vol.97 , Issue.6 , pp. 1685-1688
    • Taylor Jr., F.B.1    Peer, G.T.2    Lockhart, M.S.3    Ferrell, G.4    Esmon, C.T.5
  • 29
    • 79151469125 scopus 로고    scopus 로고
    • Circulating endothelial cell protein C receptor: Endothelial regulation and cumulative impact of gender and A3 haplotype
    • doi: 101159/000322582
    • Guitton C, Gérard N, Quillard T, Charreau B (2011) Circulating endothelial cell protein C receptor: endothelial regulation and cumulative impact of gender and A3 haplotype. J Vasc Res 48:336-346. doi: 101159/000322582
    • (2011) J Vasc Res , vol.48 , pp. 336-346
    • Guitton C, G.1
  • 31
    • 0032740411 scopus 로고    scopus 로고
    • Gender-based differences in outcome in patients with sepsis
    • 10593332 10.1001/archsurg.134.12.1342 1:STN:280:DC%2BD3c%2FlvV2jtw%3D%3D
    • SR Eachempati L Hydo PS Barie 1999 Gender-based differences in outcome in patients with sepsis Arch Surg 134 1342 1347 10593332 10.1001/archsurg.134.12. 1342 1:STN:280:DC%2BD3c%2FlvV2jtw%3D%3D
    • (1999) Arch Surg , vol.134 , pp. 1342-1347
    • Eachempati, S.R.1    Hydo, L.2    Barie, P.S.3
  • 34
    • 1842600276 scopus 로고    scopus 로고
    • Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]
    • 15025782 10.1186/cc2459
    • GT Kinasewitz SB Yan B Basson P Comp JA Russell A Cariou SL Um B Utterback PF Laterre JF Dhainaut 2004 Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569] Crit Care 8 R82 R90 15025782 10.1186/cc2459
    • (2004) Crit Care , vol.8
    • Kinasewitz, G.T.1    Yan, S.B.2    Basson, B.3    Comp, P.4    Russell, J.A.5    Cariou, A.6    Um, S.L.7    Utterback, B.8    Laterre, P.F.9    Dhainaut, J.F.10
  • 35
    • 11444268040 scopus 로고    scopus 로고
    • Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
    • DOI 10.1111/j.1432-1033.2004.04401.x
    • RJ Preston A Villegas-Mendez YH Sun J Hermida P Simioni H Philippou B Dahlback DA Lane 2005 Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation FEBS J 272 97 108 15634335 10.1111/j.1432-1033.2004.04401.x 1:CAS:528:DC%2BD2MXot1elsA%3D%3D (Pubitemid 40083070)
    • (2005) FEBS Journal , vol.272 , Issue.1 , pp. 97-108
    • Preston, R.J.S.1    Villegas-Mendez, A.2    Sun, Y.-H.3    Hermida, J.4    Simioni, P.5    Philippou, H.6    Dahlback, B.7    Lane, D.A.8
  • 36
    • 34247853512 scopus 로고    scopus 로고
    • Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3
    • DOI 10.1111/j.1538-7836.2007.02480.x
    • A Villegas-Mendez R Montes LR Ambrose AN Warrens M Laffan DA Lane 2007 Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3 J Thromb Haemost 5 980 988 17459006 10.1111/j.1538-7836.2007.02480.x 1:CAS:528:DC%2BD2sXmtFKnsr8%3D (Pubitemid 46691727)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.5 , pp. 980-988
    • Villegas-Mendez, A.1    Montes, R.2    Ambrose, L.R.3    Warrens, A.N.4    Laffan, M.5    Lane, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.