Endothelial cell protein C receptor plays an important role in protein C activation in vivo

Blood

Volumn 97, Issue 6, 2001, Pages 1685-1688

  Taylor Jr , Fletcher B ^b   Peer, Glenn T ^b   Lockhart, Marion S ^b   Ferrell, Gary ^b   Esmon, Charles T ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGENIC SUBSTRATE; ENDOTHELIAL CELL PROTEIN C RECEPTOR; FIBRIN; FIBRINOGEN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; THROMBIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBRINOLYSIS; HUMAN; HUMAN CELL; LEUKOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; THROMBOSIS; VASCULAR ENDOTHELIUM;

EID: 0035869411     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.6.1685     Document Type: Article

References (20)

1. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor
2. Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
3. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
4. Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation
5. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor
6. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
7. Protein C prevents the coagulopathic and lethal effects of E coli infusion in the baboon
8. A 23bp insertion in the endothelial protein C receptor (EPCR) gene in patients with myocardial infarction and deep vein thrombosis
9. Quantification of circulating activated protein C in human plasma by immunoassays - Enzyme levels are proportional to total protein C levels
10. The conversion of prothrombin to thrombin. I: Characterization of the reaction products formed during the activation of bovine prothrombin
11. Baboon models of three variants of the hemostatic response to the inflammatory stimuli
12. Direct detection of activated protein C in blood from human subjects
13. Methods of estimating fibrinogen concentration - Thrombin time test
14. A simple, specific one-stage assay for plasma thromboplastin antecedent activity
15. Relationship between anticoagulant activities and polyanionic properties of rabbit thrombomodulin
16. Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex
17. TAFI, or plasma procarboxypeptidase B. couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex
18. The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries
19. Factor XI activation in a revised model of blood coagulation
20. Activation of human blood coagulation factor XI independent of factor XII. Factor XII is activated by thrombin and factor XIa in the presence of negatively charged surfaces